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A preparation method of an anticoagulant material capable of inducing and catalyzing the release of endogenous NO

An induced catalysis and endogenous technology, applied in the field of biomedical engineering functional materials, can solve the problems of limited anticoagulant time, limited application, short duration, etc., and achieve excellent oxygen free radical scavenging, excellent oxidation resistance, The effect of excellent binding force

Active Publication Date: 2015-11-25
GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this NO release mode will lead to problems such as too fast release rate, too large initial release, and too short duration, causing corresponding hemopathological conditions and limited anticoagulation time, which also limits its use in anticoagulation. blood application

Method used

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  • A preparation method of an anticoagulant material capable of inducing and catalyzing the release of endogenous NO
  • A preparation method of an anticoagulant material capable of inducing and catalyzing the release of endogenous NO
  • A preparation method of an anticoagulant material capable of inducing and catalyzing the release of endogenous NO

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A method for preparing a novel anticoagulant material capable of inducing and catalyzing the release of endogenous NO, obtained by the following steps:

[0028] A. Polish, clean and dry the pure iron material that needs to be modified;

[0029] B. Place the sample obtained in step A in a buffer system with pH=5, then add a dopamine compound with a concentration of 0.01 mg / ml and cystamine with a concentration of 0.01 mg / ml to the system, and react at 10° C. for 1 h;

[0030] C. For the sample obtained in step B, immerse it in deionized water, clean it ultrasonically for 3 times, each time for 5min, and then wash it in N 2 The target material can be obtained by drying under the conditions.

Embodiment 2

[0032] A method for preparing a novel anticoagulant material capable of inducing and catalyzing the release of endogenous NO, obtained by the following steps:

[0033] A. Polish, clean and dry the magnesium-based material that needs to be modified;

[0034] B. Place the sample obtained in step A in a buffer system of pH=12, then add epigallocatechin gallate (EGCG) with a concentration of 10 mg / ml and selenocystamine with a concentration of 10 mg / ml to the system, At 30°C, react for 24h;

[0035] C. For the sample obtained in step B, immerse it in deionized water, clean it ultrasonically for 3 times, each time for 5min, and then wash it in N 2 The target material can be obtained by drying under the conditions.

Embodiment 3

[0037] A method for preparing a novel anticoagulant material capable of inducing and catalyzing the release of endogenous NO, obtained by the following steps:

[0038] A. Polish, clean and dry the medical 316L stainless steel that needs to be modified;

[0039] B. Place the sample obtained in step A in a buffer system of pH=7, then add epicatechin gallate (ECG) with a concentration of 2mg / ml and selenocystine with a concentration of 3mg / ml to the system, At 15°C, react for 4h;

[0040] C. For the sample obtained in step B, immerse it in deionized water, clean it ultrasonically for 3 times, each time for 5min, and then wash it in N 2 The target material can be obtained by drying under the conditions.

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Abstract

The invention discloses a preparation method of an anticoagulant material with function of inducing and catalyzing release of endogenous NO. The method comprises the steps of: configuring an alkaline Tris-buffer buffer solution, and adding a compound with certain concentration and pyrogallol structure and a compound with disulfide bond or diselenium bond and containing amino or thiol at two ends; and placing the substrate materials in a reaction solution, controlling the reaction temperature, reacting for 1-24 h, removing the substrate, and cleaning and drying to obtain the objective material. The invention has the advantages of simple operation, mild reaction conditions and easy operation. The component unit of the compound with disulfide bond or diselenium bond and containing amino or thiol at two ends has controllable content; the modified coating prepared by the method has excellent adhesion, and catalyzes the blood NO donors to continuously release NO molecules through in situ catalysis, inhibits activation and aggregation of platelets, inhibits proliferation of smooth muscle cells, and protects vascular endothelium.

Description

technical field [0001] The invention relates to biomedical engineering functional materials, especially the technical field of preparation of excellent anticoagulant materials. Background technique [0002] Cardiovascular implants, such as cardiovascular stents, artificial heart valves, inferior vena cava filters, artificial blood vessels, etc., have long faced the problem of anticoagulation. The surface of anticoagulant materials with excellent performance has always been the means and purpose of investigation of the function of blood contact materials. As the first signal molecule in the human body, nitric oxide (NO) plays an extremely important biological function. Years of research have shown that NO can inhibit the activation and aggregation of platelets, can greatly improve the ability of anti-thrombosis, and has the ability to inhibit Proliferative capacity of smooth muscle cells. At present, NO donor materials are mainly loaded with substances that can release NO m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L33/02A61L33/04A61L33/06
Inventor 王进罗日方杨志禄黄楠翁亚军赵元聪冷永祥杨苹
Owner GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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