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Compound effecting on hepatitis B virus

一种乙肝病毒、复合物的技术，应用在抗病毒剂、药物组合、含有效成分的医用配制品等方向，能够解决作用效果不尽如人意等问题，达到杀灭病毒提高、人体免疫力突破性的效果

Inactive Publication Date: 2014-12-17
SHANGHAI AI QI ECOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few drugs that can act on hepatitis B virus, and the effect is not satisfactory

Method used

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  • Compound effecting on hepatitis B virus
  • Compound effecting on hepatitis B virus
  • Compound effecting on hepatitis B virus

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0011] According to another preferred embodiment of the present invention, the polyphenol selenium compound having an alkali metal ion selenium complex as a functional group, wherein its preparation method comprises the following steps:

[0012] A. Hydrolyzing lignin to obtain polyphenolic compounds with multiple structures;

[0013] B. reacting the polyphenolic compound of the multi-component structure with at least one metal inorganic base to obtain a polyvalent phenolic hydroxy carboxylate;

[0014] C. Combine the polyvalent phenolic hydroxycarboxylate with SeO 2 reaction to obtain the polyphenol selenium compound with the alkali metal ion selenium complex as the functional group.

[0015] According to another preferred embodiment of the present invention, the complex acting on hepatitis B virus further includes oxymatrine and glycyrrhizin sulfate.

[0016] Preferably, the purity of the oxymatrine is ≥95%, the mass fraction of the oxymatrine is 15-50%, the purity of the g...

Embodiment 1

[0059] A polyphenol selenium compound with an alkali metal ion selenium complex as a functional group has the following structure:

[0060]

[0061] Wherein, M is an alkali metal ion.

[0062] In this embodiment, the structure:

[0063]

[0064] Also as a functional group R in other structures.

[0065] In this embodiment, the preparation method of polyphenol selenium compound with alkali metal ion selenium complex as functional group comprises the following steps:

[0066] A. Adding 2.0% urea as medium (pH=6.0) in the sulfonated lignin aqueous solution (deacidified paper pulp sulfuric acid extract) containing 20% ​​solid phase, inserts inoculum size respectively in the described medium 2% of Candida tropicalis, Pseudomonas, Candida utilis, and Em Japan strains, mixed strains with inoculation ratio of 1:2:2:2, fermented at 30°C, fermented for 72 hours, and obtained multiple-structured polyphenolic compounds;

[0067] B. reacting the polyphenolic compounds of the mult...

Embodiment 2

[0072] A polyphenol selenium compound with an alkali metal ion selenium complex as a functional group has the following structure:

[0073]

[0074] where R=CH 3 、CH 2 CH 2 CH 3

[0075] In this embodiment, the preparation method of polyphenol selenium compound with alkali metal ion selenium complex as functional group comprises the following steps:

[0076] A. Adding 2.0% urea as medium (pH=6.0) in the sulfonated lignin aqueous solution (deacidified paper pulp sulfuric acid extract) containing 20% ​​solid phase, inserts inoculum size respectively in the described medium 2% of Candida tropicalis, Pseudomonas, Candida utilis, and Em Japan strains, mixed strains with inoculation ratio of 1:2:2:2, fermented at 30°C, fermented for 72 hours, and obtained multiple-structured polyphenolic compounds;

[0077] B. reacting the polyphenolic compounds of the multi-component structure with potassium hydroxide to obtain potassium polyvalent phenolic hydroxycarboxylates, wherein the...

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Abstract

A polyphenol selenium compound used for Hepatitis B virus (HBV) and having as a functional group an alkali metal ion selenium coordination complex, and comprising a composite of, preparation method of, and use of said compound; the compound or composite has the function of directly killing HBV and destroying HBV replication templates. The composite can further comprise oxymatrine and glycyrrhizin sulfate.

Description

technical field [0001] The invention relates to a medicine for treating hepatitis B, in particular to a polyphenol selenium compound which acts on hepatitis B virus and uses an alkali metal ion selenium complex as a functional group. Background technique [0002] Hepatitis B virus (HBV) refers to the DNA virus that causes acute and chronic hepatitis B in humans. Hepatitis B is a disease caused by the hepatitis B virus. There is currently no drug that can completely cure HBV. But there are medicines that can help the patient's body fight and suppress the hepatitis B virus to control the disease. At present, there are few drugs that can act on hepatitis B virus, and the effect is not satisfactory. Contents of the invention [0003] The purpose of the present invention is to provide a compound that can effectively act on hepatitis B virus, which is mainly composed of alkali metal ion selenium complex, glycyrrhizin sulfate, and oxymatrine as supplementary compound. [0004...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P1/16A61P31/20A61K31/4375A61K31/194A61K31/352
CPCA61K31/095A61K31/366C01B19/008C07C61/13C07C2602/42C07D421/04C07C391/00C07D311/62A61P1/12A61P1/16A61P31/12A61P31/20
Inventor 陈躬宋昆元
Owner SHANGHAI AI QI ECOLOGICAL TECH
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