Blood vessel forming device and method for 3D bioprinting

Abstract

This invention discloses a blood vessel forming device and method for 3D bioprinting. The device and method are used for the bioengineering technology and aim to solve the problems that currently, when blood vessels are printed through the 3D bioprinting technologies, the blood vessels are poor in forming quality and small in forming length. According to the method, biological ink is printed on rotary rods with the surfaces coated with thermo-sensitive hydrogel through the 3D bioprinting technologies, and the needed biological blood vessels can be formed through further biological culture. According to the method, the rotary rods with different diameters and lengths can be prepared for printing the biological blood vessels with different sizes, blood vessel tissue which is uniform in thickness and accurate in printing size can be fast printed, the available 3D printing technologies are diverse, and the device and method are wide in practicability. We call the method a 3D rotational forming printing method (3Denvelop Bioprinting Method).

Description

technical field [0001] The invention relates to bioengineering manufacturing technology in the field of tissue engineering, in particular to a blood vessel forming method for 3D bioprinting. Background technique [0002] With the aging of the population and the improvement of people's living standards, the incidence of cardiovascular and cerebrovascular diseases caused by vascular diseases in my country is increasing year by year. The report shows that the number of cardiovascular disease patients in my country reached 290 million in 2012, and about 3.5 million people died of cardiovascular disease every year, accounting for 41% of the total cause of death, ranking first among various diseases. Therefore, it is imminent to actively carry out research on the treatment of vascular diseases and improve the health of the whole people. At present, the commonly used method to solve vascular diseases is blood vessel replacement and transplantation. Vascular replacement is ...

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the defects existing in the current 3D bioprinting technology when printing blood vessels, the present invention provides a forming method for printing blood vessels using 3D bioprinting technology, including the vascular forming device used in the method. The invention creatively introduces a rotating The rod is used as a support frame for blood vessel printing, and the surface of the rotating rod is used as a platform for blood vessel printing, which solves the problem of unsatisfactory formation of blood vessels when printing blood vessels with current 3D bioprinting technology, and can easily construct vascular tissue

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