Lightfast sunscreen composition

一种组合物、耐光的技术，应用在护理皮肤的制剂、含有效成分的医用配制品、化妆品等方向，能够解决稳定性低、稳定性差等问题

Active Publication Date: 2017-07-14
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been reports of low stability of dibenzoylmethanes in sunscreen compositions when applied to the skin and exposed to solar radiation
The stability is worse when oil-soluble UV-B organic sunscreens are included, especially from cinnamic acids

Method used

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  • Lightfast sunscreen composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 4

[0058] Examples 1 to 4: Photostability of compositions according to the invention compared to compositions outside the invention

[0059] Several compositions shown in Table 1 were prepared. The steps for preparing the salvia miltiorrhiza extract (embodiment 3) are as follows:

[0060] The aqueous ethanolic extract of Salvia miltiorrhiza (50 g) was redissolved in distilled water (1 L) at 45-50° C. by stirring for 15 minutes. The resulting suspension was extracted with ethyl acetate (200ml x 5). by Na 2 SO 4 The ethyl acetate layer was collected and dried on a rotary evaporator. About 10 g of dry powder are obtained.

[0061] Table 1

[0062]

[0063] #The Danshen extract used was analyzed to contain ~2.0% Tanshinone IIA. The concentration of tanshinone IIA in the extract was determined by silica gel chromatography in Comniflash and elution with gradient increments of ethyl acetate-hexane.

[0064] Procedure for determining the photostability of dibenzoylmethane c...

Embodiment 5 to 6

[0072] Examples 5 to 6: Demonstration of pure Tanshinone IIA as a photostabilizer for Parsol-1789

[0073] The efficacy of Tanshinone IIA for photostabilization of the UV-A sunscreen Parsol-1789, a dibenzoylmethane compound, was demonstrated in chloroform solution at a concentration of 5 ppm. Example 5 is a solution containing only 5 ppm Parsol-1789, while Example 6 contains 5 ppm each of Parsol-1789 and Tanshinone IIA. In Example 5, pure tanshinone IIA was extracted from the plant Salvia miltiorrhiza using the following steps;

[0074] An alcoholic aqueous extract of Salvia miltiorrhiza was first prepared by placing the root (50 g) of the plant Salvia miltiorrhiza in a 95% ethanol / water mixture at a weight ratio of root to mixture of 1:20. The extract was then redissolved in distilled water (1 L) at 45-50° C. by stirring for 15 minutes. Fractions of interest were fractionated with ethyl acetate and water. The ethyl acetate fractions were dried on a rotary evaporator. Th...

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Abstract

The present invention relates to photostable sunscreen compositions comprising sunscreen stabilizers. It is an object of the present invention to provide highly photostable sunscreen compositions, preferably derived from natural materials, while ensuring long-term efficacy of the UV-A organic sunscreens used therein. The present inventors have achieved this by including Tanshinone IIA, which is a diterpene-o-quinone, present in certain plants to achieve the desired sunscreen stabilization.

Description

technical field [0001] The present invention relates to photostable sunscreen compositions containing sunscreen stabilizers. The sunscreen stabilizers can be prepared synthetically or extracted from plants. [0002] Background of the invention [0003] Solar radiation includes ultraviolet (UV) radiation with wavelengths between 200 nanometers and 400 nanometers. Skin exposure to UV-A (320 to 400 nm) and UV-B (290 to 320 nm) can cause various problems such as skin redness, local irritation, sunburn, melanoma and wrinkle formation. UV radiation is also known to cause damage to hair. It is therefore desirable to protect the skin and other keratinous substrates of the human body from the harmful effects of UV-A and UV-B radiation. [0004] Cosmetic compositions comprising sunscreens are used for UV radiation protection of the skin. The most commonly used UV-A sunscreens are dibenzoylmethanes. They are often used with UV-B sunscreens for broad spectrum sun protection. There ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/35A61K8/49A61K8/9789A61Q17/04
CPCA61K8/35A61K8/37A61Q17/04A61K2800/52A61K8/4973A61K8/368
Inventor R·K·舒克拉V·R·甘地P·班迪奥帕迪亚伊L·李
Owner UNILEVER IP HLDG BV
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