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Polycaprolactone/calcium sulfate composite material and preparation method thereof

A polycaprolactone and composite material technology, which is applied in the field of polycaprolactone/calcium sulfate composite materials and their preparation, can solve the problem of restricting the application field, affecting the biocompatibility and degradability of polycaprolactone, and affecting the mechanics of materials performance and other issues, to achieve the effects of wide clinical application fields, improved strength and simple process

Active Publication Date: 2012-08-22
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few domestic invention patents on reinforced polycaprolactone. Chinese invention patent CN101693773A uses acorn powder to enhance and modify polycaprolactone, but the addition of acorn powder affects the biocompatibility and degradation of polycaprolactone properties, limiting its field of application
Chinese invention patent CN1593673A uses melt blending or molding to reinforce polycaprolactone with chitin fibers, but the traditional melt blending process needs to be carried out at a temperature higher than the melting point of the polymer, and the strong shear force of the screw and high temperature will cause Degrade part of polycaprolactone, thus affecting the mechanical properties of the material

Method used

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  • Polycaprolactone/calcium sulfate composite material and preparation method thereof
  • Polycaprolactone/calcium sulfate composite material and preparation method thereof
  • Polycaprolactone/calcium sulfate composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Co-precipitation method to prepare polycaprolactone and anhydrous calcium sulfate composite materials

[0029] Weigh 16g of polycaprolactone and stir it in a constant temperature water bath at 58°C for 1 hour to completely dissolve it in tetrahydrofuran; weigh 2.4g of anhydrous calcium sulfate powder and stir it at room temperature for 50 minutes to uniformly disperse it in tetrahydrofuran; Pour the tetrahydrofuran solution of caprolactone into the tetrahydrofuran suspension of anhydrous calcium sulfate and mix, and stir with a magnet at room temperature for 2 hours; after ultrasonication for 15 minutes, stir for another 2 hours; quickly pour it into a beaker containing 750ml of absolute ethanol that is being ultrasonicated In the process, a white precipitate was precipitated; the precipitate was repeatedly washed with absolute ethanol; dried in a vacuum oven at 45°C for 1 day to obtain a powdery mixture of polycaprolactone and anhydrous calcium sulfate.

[0030] (2...

Embodiment 2

[0033] (1) Co-precipitation method to prepare polycaprolactone and calcium sulfate whisker composite materials

[0034] Weigh 16g of polycaprolactone and stir it in a constant temperature water bath at 50°C for 1 hour to completely dissolve it in tetrahydrofuran; weigh 2.4g of modified anhydrous calcium sulfate powder and stir it at room temperature for 50 minutes to evenly disperse it in tetrahydrofuran ;Pour the tetrahydrofuran solution of polycaprolactone into the tetrahydrofuran suspension of calcium sulfate whiskers and mix, and stir for 2 hours at room temperature; after ultrasonication for 15 minutes, stir for another 2 hours; In the ethanol beaker, a white precipitate was precipitated; the precipitate was repeatedly washed with absolute ethanol; dried in a vacuum oven at 35°C for 1 day to obtain a powdery mixture of polycaprolactone and calcium sulfate whiskers.

[0035] (2) Compression molding of polycaprolactone and modified calcium sulfate whisker composite material...

Embodiment 3

[0038] (1) Surface modification of anhydrous calcium sulfate

[0039] Weigh 0.75g of lecithin and dissolve it in 220ml of absolute ethanol, stir at 35°C for 5 hours, and filter with suction 5 times until impurities are removed. Then add 15g of calcium sulfate, stir for 30 minutes, sonicate for 10 minutes, and stir for another 30 minutes; filter with absolute ethanol and wash 5 times; dry at 50°C in a vacuum oven for 20 hours to obtain surface-modified anhydrous sulfuric acid calcium.

[0040] (2) Co-precipitation method to prepare polycaprolactone and modified anhydrous calcium sulfate composite materials

[0041] Weigh 16g of polycaprolactone and stir it in a constant temperature water bath at 60°C for 1 hour to completely dissolve it in tetrahydrofuran; weigh 2.4g of modified anhydrous calcium sulfate powder and stir it at room temperature for 50 minutes to evenly disperse it in tetrahydrofuran ;Pour the tetrahydrofuran solution of polycaprolactone into the tetrahydrofuran...

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Abstract

The invention discloses a polycaprolactone / calcium sulfate composite material and a preparation method thereof, belonging to the field of macromolecule modification. The method comprises the following steps: utilizing biosurfactant to carry out surface modification on anhydrous calcium sulfate or calcium sulfate whiskers; and adopting a coprecipitation and mould pressing method to prepare anhydrous calcium sulfate or calcium sulfate whiskers reinforced polycaprolactone composite material. The composite material prepared by the method in the invention has the advantages of high mechanical strength and adjustable performance, thereby laying a foundation for the application thereof.

Description

technical field [0001] The invention belongs to the field of polymer modification, and in particular relates to a polycaprolactone / calcium sulfate composite material and a preparation method thereof. Background technique [0002] Polycaprolactone has water resistance, oil resistance, and chloride resistance, and has a low melting point (about 60°C) and melt viscosity, which makes it easy to process and shape. Polycaprolactone has been used in bone tissue engineering, drug sustained release and other fields due to its biocompatibility, biodegradability and low toxicity. Although it has the above-mentioned advantages, in practical applications, the mechanical strength of polycaprolactone is low and cannot meet the requirements, and it needs to be enhanced and modified. [0003] Calcium phosphate and hydroxyapatite are mainly used to strengthen polycaprolactone in China, but the degradation rate of calcium phosphate is slow, and hydroxyapatite will basically not be absorbed in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04C08K3/30C08K9/04C08K7/08B29C43/58
Inventor 任力李国元刘金彦王迎军
Owner SOUTH CHINA UNIV OF TECH
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