A magnetic tweezers device

A technology of magnetic tweezers and magnetic balls, used in instruments, scanning probe technology, etc., can solve the problems of inability to measure molecules with short lengths, low accuracy of experimental results, and time-consuming production, so as to facilitate analysis and calculation and accurate measurement. , good digital effect

Active Publication Date: 2016-12-07
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these two points are not taken into account when calculating the force and motion of the ball, so the accuracy of the measured experimental results is not high
In addition, the existing magnetic tweezers sample cell is more complex, time-consuming and costly to manufacture; the molecules in the sample cell are far away from the external magnet, resulting in a small magnetic force that can be applied, generally less than 30pN
Due to the limitations of the force measurement principle of traditional magnetic tweezers, it is impossible to measure molecules with shorter lengths below microns

Method used

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Embodiment Construction

[0027] see figure 1 and image 3 , an embodiment of the present invention provides a magnetic tweezers device for realizing the motion control of a single molecule; including:

[0028] The sample cell is used to hold the single-molecule sample and the solution; wherein, the single-molecule sample is placed in the solution, one end of the single-molecule sample is connected to the bottom of the cover glass of the sample cell, and the other end is connected to a magnetic ball;

[0029] Magnet control unit, located under the sample cell, used for motion control of the magnetic ball;

[0030] an imaging unit, configured to project light to the sample cell and output a reflected light signal that records the motion state of the magnetic ball;

[0031] The control unit is used to receive and convert the reflected light signal, and measure and analyze the movement of the magnetic ball.

[0032] During the measurement, the control unit drives the magnet control unit to act, and the...

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Abstract

The invention belongs to the technical field of microscopic imaging, and discloses a magnetic tweezers device, which is used to realize the motion control of a single molecule; it includes: a sample pool, used to hold a single-molecule sample and a solution; wherein, the single-molecule sample is placed in the solution , one end of the single-molecule sample is connected to the bottom of the cover glass of the sample cell, and the other end is connected to a magnetic ball; the magnet control unit is located under the sample cell to realize the motion control of the magnetic ball; The pool projects light and outputs a reflected light signal recording the motion state of the magnetic ball; the control unit is used to receive and convert the reflected light signal to realize the motion measurement and analysis of the magnetic ball. The invention provides a vertical upward and downward magnetic tweezers, which avoids the systematic error caused by gravity and greatly improves the measurement accuracy.

Description

technical field [0001] The invention relates to the technical field of microscopic imaging, in particular to a magnetic tweezers device. Background technique [0002] The last two decades have seen an explosion of research at the single-molecule level. People have successively developed single-molecule research techniques such as glass microneedles, atomic force microscopes, and optical tweezers to directly manipulate and detect individual molecules. Compared with the above-mentioned single-molecule manipulation techniques, magnetic tweezers have higher force measurement accuracy and will not cause damage to the sample. [0003] In the existing magnetic tweezers technology, when the magnetic ball is moving under force, it not only has the magnetic force in the horizontal direction, but also is affected by its own gravity, so there will be a gravitational interference in the vertical direction. Molecules are oriented obliquely downwards. At this time, the motion of the bal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01Q80/00
Inventor 肖波涛
Owner HUAZHONG UNIV OF SCI & TECH
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