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Premix auxiliary and preparation method thereof

A technology for premixing auxiliary materials and mixing powders, which is applied in the field of biomedicine, can solve the problems of many processes, long production time, large differences in quality and performance between batches of capsules, etc., and achieves the effect of convenient use and improved gel performance.

Active Publication Date: 2014-10-08
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In the actual production process, materials need to be input many times, there are many processes, the production time is long, the process parameters are not easy to control, and the quality and performance of capsule batches vary greatly.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 100g of hydroxypropyl starch and 200g of starch and mix evenly, add 4L of 90°C purified water, stir to make it a viscous liquid, and keep it warm for 2h. Then the liquid enters the centrifugal atomization spray dryer for spray drying, the temperature of the air inlet is controlled at 180°C, and the temperature of the outlet air is 90°C. Obtain mixed powder A;

[0027] Take 8g of gum arabic, 20g of carrageenan, 8g of guar gum, and 20g of xanthan gum and mix evenly, add 600ml of purified water, stir to make it a viscous liquid, add activated carbon to decolorize and remove impurities, filter, add 280ml of ethanol to the filtrate to precipitate, Filtration under reduced pressure, vacuum drying at 50°C to obtain mixed powder B;

[0028] Take 120g of mixed powder A, 20g of mixed powder B and 3g of brilliant blue and mix them evenly in proportion.

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Abstract

The invention discloses a premix auxiliary and a preparation method thereof. The premix auxiliary comprises the following components in parts by weight: 10-20 parts of hydroxypropyl starch, 5-10 parts of starch, 0.5-2 parts of arabic gum, 0.5-5 parts of carrageenan, 0.5-2 parts of guar gum, 0.5-5 parts of xanthan gum and 0-5 parts of colorant. After a proper amount of water or glycerinum is added into the premix auxiliary to form a solution, and the viscosity is regulated to a proper range by production equipment according to practice to prepare capsules, so that the production procedures are greatly reduced, the requirement on process parameters is simple, the production time is greatly shortened, and the product quality is stable. Furthermore, the premix auxiliary disclosed by the invention does not contain a gelatin component, and the prepared capsule is a plant capsule with higher safety and better stability and is suitable for wide applicable crowd.

Description

technical field [0001] The invention relates to a premixed auxiliary material and a preparation method thereof, belonging to the field of biomedicine. Background technique [0002] Premixed auxiliary materials refer to the uniform mixing of two or more single auxiliary materials in a certain proportion and with a certain production process in advance to become a new auxiliary material with multi-functional or specific functions and uniform appearance. The production process Commonly used are simple blending, co-drying, hot-melt extrusion, freeze-drying or co-precipitation, etc. Premixed excipients maintain or improve the advantages of single excipients. At present, the research on premixed excipients mainly focuses on direct-compression tablet premixed excipients and film coating premixed excipients. Among them, the direct-compression tablet premixed excipients only need to add the main ingredients and mix well to form tablets. ; Coating premixed auxiliary materials only n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/48
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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