A kind of chrysanthemum wall breaking preparation

A chrysanthemum and preparation technology, which is applied in the field of traditional Chinese medicine, can solve the problems of increased specific surface area of ​​powder, destruction of active ingredients, loss of active ingredients, etc., and achieves the effects of strong stability of the finished product, easy disintegration and dispersion, and easy warm water for mixing.

Active Publication Date: 2018-08-21
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, the active ingredients such as volatile oil and chlorogenic acid are unstable when heated. If the traditional decoction method is used, the active ingredients will be easily destroyed or lost.
The preparation of chrysanthemum into superfine powder of chrysanthemum is beneficial to improve the utilization rate of active ingredients, but at the same time, due to the increase of powder specific surface area, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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  • A kind of chrysanthemum wall breaking preparation
  • A kind of chrysanthemum wall breaking preparation
  • A kind of chrysanthemum wall breaking preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take the pure medicinal material of chrysanthemum, coarsely pulverize it into a coarse powder of about 100 meshes, and superfinely pulverize it into a powder in which 90% of the particle size of the ultrafine powder is less than or equal to 30 μm, and add ethanol-water solution (the mass fraction of ethanol is 50% ) soft material by wet method, the ratio of solution to superfine powder is 0.65:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules , the wet granules were placed in a hot air circulation oven, the drying temperature was set at 70°C, and dried for 2.5 hours until dry.

[0025] Note: The full score is 10.

Embodiment 2

[0027] Take the pure medicinal material of chrysanthemum, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 30 μm, add ethanol-water solution (the mass fraction of ethanol is 60%) ) soft material by wet method, the ratio of solution to superfine powder is 0.7︰1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 60r / min, and the extrusion force is 0.9MPa to make wet Granules, wet granules were transferred to a vacuum microwave drying oven, set the drying temperature to 45°C, dried for 0.75h to dryness, and chrysanthemum wall-broken preparations were obtained after whole grains were sieved.

[0028] Note: The full score is 10.

Embodiment 3

[0030] Take the pure medicinal material of chrysanthemum, coarsely pulverize it into a coarse powder of about 100 meshes, and superfinely pulverize it into a powder in which 90% of the particle size in the ultrafine powder is less than or equal to 30 μm, add ethanol-water solution (the mass fraction of ethanol is 90%) ) soft material by wet method, the ratio of solution to superfine powder is 0.9︰1 (by weight), after mixing, pre-installed 30 mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet Granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 70°C, and dried for 2.5 hours until dry.

[0031] Note: The full score is 10.

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Abstract

The invention relates to a traditional Chinese medicine preparation, in particular to a chrysanthemum wall breaking preparation. The invention grinds the chrysanthemum into superfine powder, then further granulates it by ethanol-water wet method, extrudes it at a certain speed, and dries it. Moreover, the preparation has strong stability and good disintegration.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a chrysanthemum wall breaking preparation. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the efficacy. However, th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K36/28A61K9/16A61J3/00
Inventor 成金乐赖智填徐吉银陈金梅梁学良
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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