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Apparatus and method for measuring hemostatic function using blood mobility

A blood and functional technology, applied in the direction of measuring devices, chemical instruments and methods, laboratory containers, etc.

Inactive Publication Date: 2014-09-03
KOREA UNIV RES & BUSINESS FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The device provides a similar in vivo environment as when measuring bleeding time in vitro, but the device requires a long measurement time of about 100 to 150 seconds and can only be tested on one blood sample at a time

Method used

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  • Apparatus and method for measuring hemostatic function using blood mobility
  • Apparatus and method for measuring hemostatic function using blood mobility
  • Apparatus and method for measuring hemostatic function using blood mobility

Examples

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example 1

[0064] Figure 4 A picture showing a result obtained by measuring a change in blood due to a difference in concentrations of collagen and ADP according to an embodiment of the present invention.

[0065] Such as Figure 4 As shown, "T" indicates blood into which reagents of collagen and ADP were injected, while "N" indicates blood into which no reagents were injected.

[0066] Four samples were prepared, and the concentrations of reagents for collagen and ADP injected into each sample were as follows.

[0067] (1) Sample 1: Collagen 0mg / ml and ADP 0mg / ml

[0068] (2) Sample 2: Collagen 1.84mg / ml and ADP 25mg / ml

[0069] (3) Sample 3: Collagen 1.84mg / ml and ADP 30mg / ml

[0070] (4) Sample 4: Collagen 1.84mg / ml and ADP 37.5mg / ml

[0071] In this way, changes in blood were measured by varying the concentrations of reagents for collagen and ADP in each sample. As a result, it can be seen that the blood into which the ADP reagent of 37.5 mg / ml was injected has a relatively sh...

example 2

[0087] Figure 9 A picture showing the results obtained by measuring changes in blood according to reaction time according to another embodiment of the present invention.

[0088] As shown, "T" indicates that the samples at the optimal concentrations from Example 1 - 1.84 mg / ml collagen and 37.5 mg / ml ADP - were processed. "N" indicates blood into which no reagent was injected.

[0089] Changes in each blood sample were measured at 5-minute intervals, 10-minute intervals, and 15-minute intervals after blood injection. and Figure 6 Similarly, it can be seen that as time elapses, the migration distance of blood increases when 10 minutes pass over 5 minutes passes, and the migration distance decreases again when 15 minutes passes. Here, the reduction in the migration distance can be considered to be due to the cessation of blood migration due to the cessation of bleeding due to coagulation of platelets.

[0090] Figure 10 Graphs showing results obtained by measuring change...

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Abstract

The present invention relates to an apparatus and a method for measuring a hemostatic function using blood mobility. The present invention can comprise a measurement kit; and one or more capillaries provided at the measurement kit in which a blood inlet is formed at one end and an opening communicating with the outside is formed at the other end. In addition, recesses inwardly recessed can be formed longitudinally on at least one lateral side of the capillaries. According to the present invention, it is possible to rapidly measure the hemostatic function of blood and to examine multiple samples at one time by measuring the mobility of a very small amount of blood moving the capillaries.

Description

technical field [0001] The present invention relates to an apparatus and method for measuring hemostatic function using blood mobility, and more particularly, to an apparatus and method for measuring hemostatic function using blood mobility, wherein the tube can be processed by measuring reagent Platelet abnormalities are readily determined by internal blood migration distance and by measuring hemostasis. Background technique [0002] Methods of measuring the hemostatic function of blood are widely used in screening for congenital platelet dysfunction or in preoperative screening tests, especially in bleeding disorders with nonnumerical platelet disorders due to congenital or acquired platelet dysfunction. Important trial for bleeding disorders. [0003] Recently, this method has been widely used to test the increased bleeding tendency and drug resistance due to antiplatelet drugs used in the treatment and prevention of cardiovascular and cerebrovascular diseases. [0004]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/86G01N35/08G01N33/49
CPCG01N33/86A61B5/1411B01L2300/087B01L2300/0838G01N33/4905B01L3/5027G01N33/49G01N35/08
Inventor 林采承申世铉金京娥
Owner KOREA UNIV RES & BUSINESS FOUND
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