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Acylated chitin fiber and preparation method thereof, and application of acylated chitin fiber in preparation of surgical suture

A technology of chitin fiber and acylation, applied to acylated chitin fiber and its preparation, and its application in the preparation of surgical sutures. In the field of chitin fibers, it can solve the problem of low wet strength, low joint strength, and easy breakage of surgical threads. problems, to achieve the effect of high mechanical strength, wide application and excellent performance

Inactive Publication Date: 2014-08-13
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported at home and abroad that chitin fibers and chitosan fibers are used to prepare absorbable surgical sutures, but the common problem of the existing chitin surgical sutures and chitosan surgical sutures is that the wet strength of the surgical thread is low. Especially the collusion strength is low and easy to break

Method used

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  • Acylated chitin fiber and preparation method thereof, and application of acylated chitin fiber in preparation of surgical suture
  • Acylated chitin fiber and preparation method thereof, and application of acylated chitin fiber in preparation of surgical suture
  • Acylated chitin fiber and preparation method thereof, and application of acylated chitin fiber in preparation of surgical suture

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Experimental program
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Embodiment 1

[0018] A kind of acylated chitin fiber is composed of acylated chitin, and its molecular structure formula is:

[0019]

[0020] In the formula, R 1 , R 2 or R 3 is H, acetyl (-C 2 h 3 O), propionyl (-C 3 h 5 O) or butyryl (-C 4 h 7 One or more of (2), n is greater than 100, and according to the technical common sense of those skilled in the art, the n value can be larger under the possibility that the technology can be realized, because the performance of the fiber corresponding to the larger n value is more excellent. The number of acyl groups per sugar unit of acylated chitin is greater than 1, that is, the degree of acylation of acylated chitin is greater than 100%, and the average number of acyl groups in every 100 sugar units is greater than 100; the acyl groups are acetyl, propylene One or more of acyl or butyryl, the acylation degree is the sum of one or more acylation degrees of acetyl, propionyl or butyryl in the acylated chitin. Therefore, the degree of ...

Embodiment 2

[0023] The preparation method of the acylated chitin fiber is as follows: take 50 g of commercially available chitin fiber, fix the fiber on a plastic stirring support, keep the fiber orderly, and set it aside for later use. Add 30mL of the acylating reagent acetic anhydride solution into the glass reaction vessel (the molar ratio of chitin fiber to acetic anhydride is 1:1.26), and add a 70% perchloric acid solution by weight according to 5% of the volume of the acetic anhydride solution 1.5ml was used as a catalyst, and 220ml of methanol was added to make the solid-to-liquid ratio (w / v) of the reaction system 1:5, and stirred evenly. Then put the chitin fiber and the bracket into the above glass reaction vessel, close the reaction vessel, control the reaction temperature to 10° C., and stir for 24 hours. After the reaction is complete, take out the fiber, remove the excess reaction solution, put the fiber into a 10% NaOH alkaline aqueous solution by weight, neutralize the aci...

Embodiment 3

[0025] The preparation method of the acylated chitin fiber is as follows: weigh 50 g of the chitin fiber, fix the fiber on a plastic stirring support, and set aside. Add 80 mL of acylating reagent butyric anhydride solution (the molar ratio of chitin fiber to butyric anhydride is 1:2.06) in the glass reaction vessel, add 2 ml of sulfuric acid solution with a concentration of 70% by weight according to 2.5% of the volume of butyric anhydride solution as Catalyst, add 220ml of ethanol to make the solid-to-liquid ratio (w / v) of the reaction system 1:6, and stir evenly. Then put the chitin fiber and the bracket into the above glass reaction vessel, close the reaction vessel, control the reaction temperature to 0° C., and stir for 72 hours. After the reaction is complete, take out the fiber, remove the excess reaction solution, put the fiber into an alkaline aqueous solution of NaOH with a concentration of 20% by weight, neutralize the acid and alkali, take out the fiber, wash with...

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Abstract

The invention provides an acylated chitin fiber and a preparation method thereof, and application of the acylated chitin fiber in preparation of a surgical suture. The acylated chitin fiber is composed of acylated chitin, the acylation degree of the acylated chitin fiber is greater than 100%, and an acyl group is one or more selected from the group consisting of an acetyl group, a propionyl group and a butyryl group. The invention further provides a preparation method for the acylated chitin fiber. The acylated chitin fiber has wide application prospects in preparation of absorbable surgical sutures. The absorbable surgical sutures prepared from the acylated chitin fiber can be used in clinical surgical operations of general surgery, cosmetic surgery, digestive surgery, gynaecology and the like; as absorbable surgical sutures, the sutures can be degraded and absorbed in human bodies, do not need to be taken out through second operations, have good biocompatibility and small tissue inflammatory response, are capable of promoting healing of surgical incisions and inhibiting hyperplasia of scars and have wide market prospects.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a chitin fiber, in particular to an acylated chitin fiber, a preparation method thereof and an application in preparing surgical sutures. Background technique [0002] Chitin is a natural polymer polysaccharide rich in resources. Its biosynthesis in nature is second only to cellulose. It mainly comes from the shells of shrimp and crabs and the cell walls of fungi. After deacetylation, chitin becomes chitosan . Both chitin and chitosan are high molecular polysaccharides, and both have good casting and silk-forming properties under appropriate solvent conditions. Chitin fiber and chitosan fiber are biodegradable, non-toxic, and non-immunogenic. They are ideal medical polymer materials and have received extensive attention in the fields of textiles and medical materials. At present, chitosan fiber has been produced on a large scale. Because chitin is difficult to dissolve in gene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08D01F9/00A61L17/10
Inventor 刘万顺韩宝芹邵凯
Owner OCEAN UNIV OF CHINA
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