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Preparation method of magnetic imprinted polymer for separating and purifying ractopamine

A technology of imprinted polymers and ractopamine, which is applied in chemical instruments and methods, and other chemical processes, can solve the problems of magnetic iron tetroxide leakage and other problems, achieve good paramagnetism, fast adsorption rate, and satisfy the effect of rapid detection

Inactive Publication Date: 2014-08-06
BOHAI UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0007] Aiming at the above-mentioned deficiencies in the prior art, the present invention proposes a preparation method for separating and purifying ractopamine magnetic molecularly imprinted polymers, which mainly solves the problem of the magnetic properties of the existing magnetic ractopamine molecularly imprinted polymers in the process of template elution and practical application. The problem of the leakage of ferric oxide

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  • Preparation method of magnetic imprinted polymer for separating and purifying ractopamine
  • Preparation method of magnetic imprinted polymer for separating and purifying ractopamine
  • Preparation method of magnetic imprinted polymer for separating and purifying ractopamine

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preparation example Construction

[0041] The preparation method of the magnetically imprinted polymer for separating and purifying ractopamine of the present invention, the steps are as follows:

[0042] (1) Preparation of magnetic iron tetroxide (Fe 3 o 4 ) nanospheres:

[0043] FeCl 2 4H 2 O and FeCl 3 ·6H 2 O was placed in a three-necked flask, deionized water after ultrasonic degassing was added, and mechanically stirred under nitrogen protection; then the reaction system was heated and ammonia water was added drop by drop, and after the addition was completed, it was crystallized at a constant temperature; after the crystallization was completed, the temperature was naturally lowered To room temperature, use a magnet to separate the black product Fe synthesized in the solution 3 o 4 , rinse the Fe with deionized water 3 o 4 , remove the unreacted solvent until the solution is neutral, and the product is vacuum-dried for subsequent use;

[0044] (2) Preparation of 3-aminopropyltrimethoxysilane (A...

Embodiment 1

[0062] A method for preparing magnetically imprinted polymers for separating and purifying ractopamine, the steps of which are as follows:

[0063] (1) Preparation of magnetic ferric oxide nanospheres:

[0064] Take 0.03mol FeCl 2 4H 2 O and 0.06 mol FeCl 3 ·6H 2 O was added to a three-necked flask, and then 300 mL of deionized water after ultrasonic degassing was added, and mechanically stirred under nitrogen protection. Heat the reaction system to 65°C and add 60mL ammonia water dropwise. After the dropwise addition, crystallize at a constant temperature at 65°C for 60 minutes; after the crystallization is completed, let the temperature drop to room temperature naturally, and use a magnet to separate the black product Fe 3 o 4 , rinse the Fe with deionized water 3 o 4 , remove the unreacted solvent until the solution is neutral, and the product is vacuum-dried at 45°C for 24h before use.

[0065] (2) Preparation of 3-aminopropyltrimethoxysilane (ATPS) modified ferric...

Embodiment 2

[0072] A method for preparing magnetically imprinted polymers for separating and purifying ractopamine, the steps of which are as follows:

[0073] (1) Preparation of magnetic ferric oxide nanospheres:

[0074] Take 0.03mol FeCl 2 4H 2 O and 0.06 mol FeCl 3 ·6H 2 O was added to a three-necked flask, then 240 mL of deionized water after ultrasonic degassing was added, mechanically stirred under the protection of nitrogen, the reaction system was heated to 60 °C, and 54 mL of ammonia water was added dropwise, and after the addition was completed, it was crystallized at a constant temperature at 60 °C for 80 min; After the crystallization is completed, the temperature is naturally lowered to room temperature, and the black product Fe synthesized in the solution is separated by a magnet. 3 o 4 , rinse the Fe with deionized water 3 o 4 , remove the unreacted solvent until the solution is neutral, and the product is vacuum-dried at 40° C. for 30 h before use.

[0075] (2) Pr...

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Abstract

The invention relates to a preparation method of a magnetic molecularly-imprinted polymer for separating and purifying ractopamine, aiming to solve the problem of leakage of magnetic ferroferric oxide in the processes of template elution and practical application of an existing magnetic ractopamine molecularly-imprinted polymer. The method comprises the steps of (1) preparing magnetic ferroferric oxide nano microspheres; (2) preparing an ATPS-modified ferroferric oxide material (ATPS-Fe3O4); (3) preparing a magnetic Fe3O4 functional monomer (MAC-ATPS-Fe3O4); (4) preparing a magnetic RAC molecularly-imprinted polymer (Fe3O4@MIPs). The prepared ractopamine magnetic molecularly-imprinted polymer disclosed by the invention is stable in performance, and can solve the problem of leakage of magnetic ferroferric oxide; the magnetic polymer has a relatively fast adsorption rate to ractopamine, meets the needs of rapid detection, has a rapid magnetic separation capacity, and is very suitable for field sample treatment.

Description

technical field [0001] The invention relates to a preparation method of a core-shell type magnetic molecularly imprinted polymer, in particular to a preparation method for separating, purifying and enriching ractopamine magnetic nanometer molecularly imprinted polymer. Background technique [0002] Ractopamine (RAC) belongs to β 2 - Stimulant, can selectively stimulate the beta of cell membrane smooth muscle 2 -receptor, clinically used to prevent and treat congestive heart failure, bronchial asthma and muscular atrophy. RAC is a kind of "lean meat extract", which can show "nutrient redistribution effect", by changing the metabolic pathway of nutrients, it can promote animal muscle growth and animal protein deposition, especially the synthesis of protein in skeletal muscle. At the same time, it inhibits the synthesis and accumulation of fat, so as to improve the carcass quality and accelerate the growth rate. However, RAC remains in the blood for a long time and has serio...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08F222/14C08J9/26B01J20/26B01J20/30
Inventor 汤轶伟兰建兴励建荣高雪张德福
Owner BOHAI UNIV
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