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Plastic bone graft material capable of enhancing and accelerating bone formation and its preparation method

A plastic and bone transplantation technology, applied in medical science, prosthesis, etc., can solve the problems of further improvement of osteogenic ability, time-consuming and laborious, powder migration, etc., to achieve broad clinical application prospects, reduce patient pain, and accelerate bone. effect

Inactive Publication Date: 2016-04-27
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the 1960s, Urist discovered that demineralized bone matrix (DBM) has the ability to induce osteogenesis. DBM has been clinically used in bone transplantation for decades, and its safety is relatively reliable, but the disadvantage is that its osteoinductivity is limited. Influenced by the donor and the preparation process, the osteogenic ability needs to be further improved
However, there are many problems in implanting the powdered bone graft material into the bone graft site through this transplantation method. In addition to the time-consuming and labor-intensive implantation of the bone material powder into the bone graft site by scooping, the bone graft material powder is easily removed from the Implantation site migration, postoperative instability, unfixation, etc. These problems limit the clinical application of powdered bone graft materials

Method used

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  • Plastic bone graft material capable of enhancing and accelerating bone formation and its preparation method
  • Plastic bone graft material capable of enhancing and accelerating bone formation and its preparation method
  • Plastic bone graft material capable of enhancing and accelerating bone formation and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of Plastic Bone Graft Material

[0035] (1) Preparation of decalcified bone matrix (DBM) powder

[0036] Wash the long bone of the donor, remove the periosteum, muscle, connecting tissue and cartilage, wash it with distilled water, cut it into small pieces of bone, freeze-dry it and crush it into a powder with a particle size of 500-1500 μm in liquid nitrogen. The obtained powder was degreased with chloroform for 12 hours, then decalcified with hydrochloric acid with a concentration of 0.5 mol / L for 4 hours, and the decalcified powder was washed with distilled water until the eluate was neutral. After the cleaned powder is freeze-dried, dehydrated, and gamma-ray sterilized, DBM powder is obtained, and its scanning electron microscope (SEM) picture is as follows: figure 1 shown.

[0037] (2) Preparation of calcium strontium polyphosphate powder

[0038] Weigh strontium carbonate and calcium carbonate according to the molar content of strontium i...

Embodiment 2

[0043] Example 2: Preparation of Plastic Bone Graft Material

[0044] (1) Preparation of decalcified bone matrix (DBM) powder

[0045] Wash the long bone of the donor, remove the periosteum, muscle, connective tissue and cartilage, wash it with distilled water, cut it into small pieces of bone, freeze-dry it and crush it into a powder with a particle size of 500-1000 μm in liquid nitrogen. The obtained powder was degreased with ether for 18 hours, and then decalcified with 1 mol / L acetic acid for 24 hours, and the decalcified powder was washed with distilled water until the eluate was neutral. DBM powder is obtained after the cleaned powder is freeze-dried, dehydrated, gamma-ray sterilized and sterilized.

[0046] (2) Preparation of calcium strontium polyphosphate powder

[0047] Weigh strontium carbonate and calcium carbonate according to the molar content of strontium ions accounting for 45% of the total molar weight of strontium ions and calcium ions, mix the strontium ca...

Embodiment 3

[0052] Example 3: Preparation of Plastic Bone Graft Material

[0053] (1) Preparation of decalcified bone matrix (DBM) powder

[0054] Wash the long bone of the donor, remove the periosteum, muscle, connecting tissue and cartilage, wash it with distilled water, cut it into small pieces of bone, freeze-dry it and crush it into a powder with a particle size of 1000-1500 μm in liquid nitrogen. The obtained powder was degreased with acetone for 24 hours, then decalcified with formic acid with a concentration of 1 mol / L for 24 hours, and the decalcified powder was washed with distilled water until the eluate was neutral. DBM powder is obtained after the cleaned powder is freeze-dried, dehydrated, gamma-ray sterilized and sterilized.

[0055] (2) Preparation of calcium strontium polyphosphate powder

[0056] Weigh strontium dihydrogen phosphate and calcium dihydrogen phosphate according to the molar content of strontium ions accounting for 35% of the total molar weight of strontiu...

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Abstract

The invention provides a bone graft material with plasticity and the capability of enhancing and accelerating bone formation. The bone graft material is a paste colloid and mainly comprises a demineralized bone matrix, polyphosphoric acid strontium calcium or polyphosphoric acid strontium, and a carrier material. The preparation method of the bone graft material comprises the following steps: degreasing and decalcifying a donated bone, and performing disinfection and sterilization, so as to obtain demineralized bone matrix powder; batching strontium dihydrogen phosphate and monocalcium phosphate, and sintering, so as to obtain the crystalline state polyphosphoric acid strontium calcium; or continuously heating the obtained polyphosphoric acid strontium calcium until the polyphosphoric acid strontium calcium is melted, and then pouring the molten polyphosphoric acid strontium calcium into ice water or ice to be subjected to quick chilling and quenching, so as to obtain non-fixed state polyphosphoric acid strontium calcium; or sintering the strontium dihydrogen phosphate to obtain the polyphosphoric acid strontium; smashing the polyphosphoric acid strontium calcium or the polyphosphoric acid strontium; uniformly mixing the demineralized bone matrix powder, the polyphosphoric acid strontium calcium powder or polyphosphoric acid strontium powder, and the carrier material according to a determined proportion of the bone graft material with plasticity, so as to obtain the bone graft material. The bone graft material provided by the invention has the capability of enhancing and accelerating bone formation, and can meet the requirement of clinic on the plasticity of bone graft materials at the same time.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to the technical field of biomedical bone materials suitable for treating human bone tissue injuries and diseases. Background technique [0002] Bone defects and bone tissue diseases caused by trauma, developmental deformities, degenerative diseases, and bone tumors have always been one of the important factors threatening human health. At present, bone grafting is mainly used clinically to treat the above-mentioned diseases, and whether the bone graft material can achieve later osteogenesis is the key to the success of bone grafting. Traditional bone graft materials include autologous bone, allograft bone, xenograft bone and artificial bone. Autologous bone is still the gold standard for bone transplantation because of its good osteoconduction, osteoinduction and osteogenesis. Complications such as pain, fractures, deep infections, and abdominal hernias. Allograft b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/36A61L27/20A61L27/22A61L27/50
Inventor 田猛游潮李浩林森郑峻陈茜
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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