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Concentrated oral solution for treating recurrent oral ulcer by type of fire excess from yin deficiency

A technology for recurrent aphthous ulcers and yin-deficiency fire-prosperity type, which is applied in the field of medicine, can solve the problems of low content of active ingredients, high cost, large side effects, etc., and achieves improved concentration and content of active ingredients, improved quality and effect, and high content of active ingredients. Effect

Inactive Publication Date: 2014-08-06
河南百年康鑫药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a concentrated oral liquid for the treatment of recurrent aphthous ulcers caused by yin deficiency and hyperactivity of fire, which can effectively solve the problem of poor curative effect, difficult cure, long treatment cycle, large side effects, impurities Many, low extraction utilization rate, low active ingredient content, poor taking effect, inconvenient to carry, high cost and not suitable for mass production

Method used

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  • Concentrated oral solution for treating recurrent oral ulcer by type of fire excess from yin deficiency
  • Concentrated oral solution for treating recurrent oral ulcer by type of fire excess from yin deficiency

Examples

Experimental program
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Effect test

Embodiment 1

[0016] The present invention can also be made from 9kg of Nansha ginseng, 3kg of coptis, 7kg of salvia miltiorrhiza, 6kg of dendrobium, 25kg of habitat, 12kg of scrophulariae, 12kg of Anemarrhena, 6kg of Chinese yam, 10kg of forsythia and 9kg of trichosanthemi, wherein:

[0017] (1) Rinse and wash the above-mentioned raw materials with water respectively, mix them, add water to decoct twice, add water 6 times the weight of the above-mentioned raw materials each time, decoct for 1 hour each time, filter, and combine the filtrates twice, Extract concentrated to 50°C with a density of 1.4;

[0018] (2) Let the extract stand for 12 hours, take the supernatant, add 0.5g of honey-sucrose mixture and 0.005g of sodium benzoate to each 1ml of the supernatant, boil and dissolve to obtain a solution;

[0019] (3) Add water of 0.1 times the total weight of the raw drug to the solution, stir evenly, refrigerate for 24 hours, and take the supernatant;

[0020] (4) Centrifuge the supernatan...

Embodiment 2

[0023] The present invention can also be made from 12kg of Nansha ginseng, 4kg of coptis, 8kg of salvia miltiorrhiza, 10kg of dendrobium, 28kg of habitat, 13kg of scrophulariaceae, 14kg of anemarrhena, 8kg of Chinese yam, 13kg of forsythia and 12kg of trichosanthum pollen, wherein:

[0024] (1) Rinse and wash the above-mentioned raw materials with water respectively, mix them, add water to decoct twice, add water 8 times the weight of the above-mentioned raw materials each time, decoct for 1.5 hours each time, filter, and combine the filtrates twice, Extract concentrated to a density of 1.25 at 60°C;

[0025] (2) Let the extract stand for 18 hours, take the supernatant, add 0.015g of glycyrrhizin solution and 0.005g of sodium benzoate to each 1ml of the supernatant, boil and dissolve to obtain a solution;

[0026] (3) Add water of 0.1 times the total weight of the raw drug to the solution, stir evenly, refrigerate for 36 hours, and take the supernatant;

[0027] (4), the supe...

Embodiment 3

[0030] The present invention can also be made from 15kg of Nansha ginseng, 6kg of coptis, 9kg of salvia miltiorrhiza, 15kg of dendrobium, 30kg of raw land, 15kg of scrophulariaceae, 15kg of anemarrhena, 10kg of Chinese yam, 15kg of forsythia and 15kg of trichosanthum pollen, wherein:

[0031] (1) Rinse and wash the above-mentioned raw materials with water respectively, mix them, add water to decoct twice, add water 12 times the weight of the above-mentioned raw materials each time, decoct for 2 hours each time, filter, and combine the filtrates twice, Extract concentrated to a density of 1.1 at 80°C;

[0032] (2) Let the extract stand for 24 hours, take the supernatant, add 0.035g of stevioside solution and 0.005g of sodium benzoate to each 1ml of the supernatant, boil and dissolve to obtain a solution;

[0033] (3) Add water of 0.1 times the total weight of the raw drug to the solution, stir evenly, refrigerate for 48 hours, and take the supernatant;

[0034] (4), the supern...

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Abstract

The invention relates to a concentrated oral solution for treating recurrent oral ulcer by type of fire excess from yin deficiency, which can be used for effectively solving the problems of poor curative effect, hard healing, long treatment cycle, high side effect, more impurities, low extract utilization, low content of effective components, poor administration effect and inconvenience in carrying. The oral solution is prepared from adenophora tetraphylla, coptis chinensis, salviae miltiorrhizae, dendrobium, unprocessed rehmannia root, radix scrophulariae, rhizoma anemarrhenae, yam, fructus forsythiae and radices trichosanthis by the following steps: washing the components, mixing, decocting twice, filtering, concentrating, and combining the filtrates; concentrating to obtain extract, standing, taking supernate, and adding a honey and cane glucose mixture or a glycyrrhizin solution or a stevioside solution; adding sodium benzoate, boiling to dissolve; adding water, uniformly stirring, refrigerating and centrifugally separating the supernate; and performing ultrafiltration on the supernate by an ultrafiltration membrane, encapsulating the ultrafiltrate, and sterilizing. The concentrated oral solution is small in side effects, increased in concentration and content of effective ingredients, small in dosage and convenient to take and carry, and is suitable for patients who cannot decoct decoction or are difficult to take medicines.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a concentrated oral liquid for treating recurrent aphthous ulcers of yin deficiency and hyperactivity of fire. Background technique [0002] Recurrent aphthous ulcers, also known as aphthous stomatitis, are small and painful ulcers on the oral mucosa, with periodic, recurrent, and self-limiting characteristics, and the ulcers have obvious burning pain. The traditional Chinese medical science thinks that its etiology and pathogenesis are weakness of the spleen and stomach, asthenic fire and inflammation. The fiery evil invades the viscera and is fumigated in the mouth. Improper diet, overeating fat, sweet and thick taste, transforms heat and dampness. Excessive thinking, emotional discomfort. The water-cold air is superior, forcing the external inflammation of the heart-fire and the imbalance of Chong and Ren can lead to this disease. [0003] Most of the ulcers are scattered and distr...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P1/02
Inventor 郭鑫慧蔡俊安王粉
Owner 河南百年康鑫药业有限公司
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