A kind of lotion effervescent tablet and preparation method thereof

A technology of effervescent tablet and lotion, which is applied in the direction of medical formula, medical preparations containing active ingredients, organic active ingredients, etc. It can solve the problems of shortened storage time of medicine effect, inconvenient carrying, unsatisfactory effect of gynecological inflammation, etc. , to achieve the effect of prolonging the storage time of the drug effect, broad spectrum of bactericidal and bacteriostatic effects, and easy to carry

Active Publication Date: 2016-05-25
JINZHOU JIUYANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, internal lotion is one of the treatment methods for treating gynecological inflammation, and it is easy to use. However, this type of lotion on the market is often used to inhibit one or the same type of bacteria, resulting in unsatisfactory effects of lotion on treating gynecological inflammation.
And the lotion has the disadvantages of being portable and inconvenient, and the storage time of the drug effect is shortened

Method used

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  • A kind of lotion effervescent tablet and preparation method thereof
  • A kind of lotion effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. Weigh raw materials

[0045] Based on a batch of 1000 tablets, weigh 36g of chlorhexidine acetate, 90g of polyhexamethylene biguanide, 3g of vitamin C, 500g of sodium bicarbonate, and 900g of tartaric acid as the main ingredients. For later use, weigh 1g of crospovidone, 35g Povidone K30, 15g soluble starch, 70g polyethylene glycol 6000, 100g adipic acid, 50g carboxymethyl starch sodium as auxiliary materials, for subsequent use;

[0046] 2. Crushing

[0047] Polyethylene glycol 6000 and adipic acid are respectively pulverized into 100 mesh fine powder with a universal pulverizer, and set aside;

[0048] 3. Premix

[0049] Sodium bicarbonate, vitamin C, chlorhexidine acetate and soluble starch were put into a high-efficiency mixer and mixed for 2 minutes to obtain a mixture;

[0050] 4. Soft materials

[0051] Adding a mass percent concentration of 5% povidone K30 solution formulated with ethanol to the mixed material, the volume concentration of the ethanol is 9...

Embodiment 2

[0069] 1. Weigh raw materials

[0070] Based on a batch of 1000 tablets, weigh 90g of chlorhexidine acetate, 36g of polyhexamethylene biguanide, 7g of vitamin C, 900g of sodium bicarbonate, and 500g of tartaric acid as the main ingredients. For later use, weigh 3g of crospovidone, 50g Povidone K30, 8g soluble starch, 20g polyethylene glycol 6000, 176g adipic acid, 10g carboxymethyl starch sodium as auxiliary materials, for subsequent use;

[0071] 2. Crushing

[0072] Polyethylene glycol 6000 and adipic acid are respectively pulverized into 100 mesh fine powder with a universal pulverizer, and set aside;

[0073] 3. Premix

[0074] Sodium bicarbonate, vitamin C, chlorhexidine acetate and soluble starch were put into a high-efficiency mixer and mixed for 7 minutes to obtain a mixture;

[0075] 4. Soft materials

[0076] Adding ethanol to the mixed material with a mass percentage concentration of 5% povidone K30 solution, the volume concentration of the ethanol is 95%, and m...

Embodiment 3

[0088] 1. Weigh raw materials

[0089] Based on a batch of 1000 tablets, weigh 50g of chlorhexidine acetate, 50g of polyhexamethylene biguanide, 5g of vitamin C, 641g of sodium bicarbonate, and 640g of tartaric acid as the main ingredients. For later use, weigh 2g of crospovidone, 20g Povidone K30, 12g soluble starch, 50g polyethylene glycol 6000, 300g adipic acid, 30g carboxymethyl starch sodium as auxiliary materials, for subsequent use;

[0090] 2. Crushing

[0091] Polyethylene glycol 6000 and adipic acid are respectively pulverized into 100 mesh fine powder with a universal pulverizer, and set aside;

[0092] 3. Premix

[0093] Sodium bicarbonate, vitamin C, chlorhexidine acetate and soluble starch were put into a high-efficiency mixer and mixed for 5 minutes to obtain a mixture;

[0094] 4. Soft materials

[0095] Adding ethanol to the mixed material with a mass percentage concentration of 5% povidone K30 solution, the volume concentration of the ethanol is 95%, and ...

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Abstract

The invention provides washing liquor effervescent tablets and a preparation method thereof. The washing liquor effervescent tablets comprise the following raw materials: chlorhexidine acetate, polyhexamethylene biguanidine hydrochloride, vitamin C, and sodium bicarbonate; tartaric acid is taken as a main material; crospovidone, povidone K30, soluble starch, polyethyleneglycol 6000, carboxymethyl starch sodium, and butane dicarboxylic acid are weighed as auxiliary materials. The preparation method comprises the following steps: mixing the sodium bicarbonate, the vitamin C, the chlorhexidine acetate, and the soluble starch; adding 5% of povidone K30 solution, and mixing the materials to prepare a soft material; conducting granulation on the soft material, and transferring the soft material in a fluidized drying granulator to dry and granulate; adding the tartaric acid, the polyethyleneglycol 6000, the butane dicarboxylic acid, the polyhexamethylene biguanidine hydrochloride, the carboxymethyl starch sodium, and the crospovidone for total mixing; loading the mixture into a hopper of a tablet machine to compress the mixture into tablets to obtain the washing liquor effervescent tablets. The washing liquor effervescent tablets are good in effect curing gynecological inflammation, and convenient to carry and store; the drug effect storage time is prolonged; various bacteria leading gynecological inflammation can be killed.

Description

technical field [0001] The invention relates to a lotion effervescent tablet and a preparation method thereof. Background technique [0002] As a common gynecological disease in women, gynecological inflammation seriously affects women's physical and mental health and life. Gynecological inflammation is generally caused by bacterial infection. The main clinical features are changes in the characteristics of leucorrhea and itching and burning pain in the vulva. When the infection is severe, the urethra will be involved, accompanied by symptoms such as dysuria, inflammation and urgency. It is not easy to cure, and it is easy to recur. If it is not treated in time, it is very likely to deteriorate. [0003] At present, internal lotion is one of the treatment methods for gynecological inflammation, and it is convenient to use. However, this type of lotion on the market is often used to inhibit one or the same type of bacteria, resulting in unsatisfactory effect of lotion on tre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/785A61K9/46A61P15/00A61P31/04A61K31/155
Inventor 刘晓渊佟彦波王雷
Owner JINZHOU JIUYANG PHARMA CO LTD
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