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Rheumatoid arthritis treatment traditional Chinese medicine composition

A rheumatoid and composition technology, applied in the direction of drug combination, antipyretic, anti-inflammatory agent, etc., can solve problems such as hepatomegaly and necrosis, and achieve the effect of reducing liver toxicity and reasonable compatibility

Active Publication Date: 2014-07-30
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the course of taking tripterygium wilfordii and its preparations, many patients have to stop the administration due to the increase of serum transaminases. Generally, they are given liver-protecting and enzyme-lowering treatment, and most of them can return to normal, but severe cases may cause hepatomegaly or acute liver disease. necrosis

Method used

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  • Rheumatoid arthritis treatment traditional Chinese medicine composition
  • Rheumatoid arthritis treatment traditional Chinese medicine composition
  • Rheumatoid arthritis treatment traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Effect of Tripterygium wilfordii and Schisandra chinensis on mouse spleen lymphocyte proliferation

[0026] (1) Materials: Schisandra, Tripterygium wilfordii.

[0027] Water extract of traditional Chinese medicine materials: 6mg / mL, 15mg / mL Tripterygium wilfordii compatible with Schisandra culture solution Preparation: take 9g of Tripterygium wilfordii, add 360mL of purified water to fry for 1 hour, then add 27g of Schisandra, fry for 1 hour, filter; add 360mL of filter residue Purified water was decocted for 1 hour, filtered; the combined filtrates were concentrated at normal pressure to contain 600 mg of Tripterygium wilfordii medicinal material per mL to obtain the aqueous extract of Tripterygium wilfordii Schizandra with a drug concentration of 600 mg / mL for later use. Before use, take 1mL of the spare medicinal solution, add sterile 1640 culture solution to set the volume to 50mL, and prepare a test solution containing 12mg of Tripterygium officinalis pe...

Embodiment 2

[0036] Example 2: Effect of Tripterygium wilfordii and Schisandra chinensis on mouse liver cell proliferation

[0037] (1) Materials: Schisandra, Tripterygium wilfordii.

[0038] Chinese medicinal material culture solution and its preparation are the same as in Example 1.

[0039] Experimental animals: clean grade ICR mice, female, 18-22g.

[0040] (2) Experimental method: Use the RPMI1640 medium containing 10% fetal bovine serum, 100IU / ml penicillin, and 100μg / ml streptomycin to store the purchased L-02 human hepatocytes at 37°C and 5% CO 2 Subculture in a humidified incubator. Take the cells in the logarithmic growth phase, digest them with 0.25% trypsin, and make a single cell suspension with RPMI1640 culture medium containing 10% fetal bovine serum; take 20 μL of the cell suspension and 0.4% trypan blue solution at a ratio of 1:1 Mix well, add to the grid of the red blood cell counting board and cover with a glass slide, count 200 cells after 1 min, the percentage of th...

Embodiment 3

[0045] Example 3: Effect of tripterygium wilfordii combined with Schisandra chinensis on liver function in adjuvant arthritis (AA) model rats

[0046] (1) Materials: Schisandra chinensis, Tripterygium wilfordii, complete Freund's adjuvant from sigma company.

[0047] Chinese medicinal material water extract: 600mg / mL Tripterygium wilfordii water extract, 600mg / mL Tripterygium wilfordii compatible Schisandra water extract, 1.8g / mL Schisandra water extract, the preparation method of Chinese medicinal material water extract is as described in Example 1 of the same.

[0048] Experimental animals: clean grade wistar rats, female, 180-220g.

[0049] (2) Experimental method: Divide the rats into blank group, model group, Tripterygium wilfordii group, Schisandra chinensis group, Tripterygium wilfordii combined with Schisandra chinensis group, 6 rats in each group, intradermal injection of the right toe of rats in the blank group 0.1mL of sterile water for injection, and intradermal ...

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Abstract

The present invention discloses a rheumatoid arthritis treatment traditional Chinese medicine composition, which is prepared from the following bulk drugs by mass: 1-20 parts of tripterygium wilfordii hook f, and 10-600 parts of schisandra chinensis. According to the present invention, with the compatibility, liver toxicity caused by tripterygium wilfordii hook f can be effectively reduced, and the synergistic effect is provided for treatment of rheumatoid arthritis with tripterygium wilfordii hook f.

Description

(1) Technical field [0001] The invention relates to a traditional Chinese medicine composition. The traditional Chinese medicine composition is specifically made of Schisandra chinensis and Tripterygium wilfordii. The compatibility can effectively reduce the liver toxicity caused by Tripterygium wilfordii, and has a positive effect on the treatment of rheumatoid arthritis by tripterygium wilfordii. Efficacy, belongs to the technical field of medicine. (2) Background technology [0002] Triptergium wilf ordii Hook.F is the root of Triptergium wilf ordii Hook.F in the Euonymus family. It has the effects of expelling wind and dampness, promoting blood circulation and dredging collaterals, reducing swelling and relieving pain, killing insects and detoxifying. The clinical application first appeared in "Wang Lianshi Prescription" in "Compendium of Materia Medica Supplements". It is mainly used as an insecticide and for the treatment of rheumatoid arthritis and other diseases. It...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61P19/02A61P29/00
Inventor 范永升沈炜石森林陈方明曹灵勇陈敏达
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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