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Traditional Chinese medicine composition for resisting liver cancer and lung cancer

An anti-liver cancer and composition technology, applied in the field of traditional Chinese medicine, can solve the problems of weak effect, difficult to achieve superimposed effect of curative effect, unable to achieve ideal effect, etc.

Active Publication Date: 2014-07-23
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although yam polysaccharide has anti-tumor effect, its effect is weak when used alone, and the desired effect cannot be achieved
[0005] So far, there are many reports on traditional Chinese medicines against liver cancer and lung cancer. It is difficult to achieve the expected superimposed effect of any three traditional Chinese medicines with anti-liver and lung cancer effects.

Method used

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  • Traditional Chinese medicine composition for resisting liver cancer and lung cancer
  • Traditional Chinese medicine composition for resisting liver cancer and lung cancer
  • Traditional Chinese medicine composition for resisting liver cancer and lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The total saponin extract of Chonglou is extracted by the following method:

[0020] Soak the chrysanthemum powder passed through a 4-mesh sieve with 8 mass times the volume ratio of 60% ethanol aqueous solution for 1.5 hours, heat and reflux extraction twice, each time for 2 hours, filter, combine the extracts and concentrate to 1% of the weight of the chrysanthemum part / 5, the concentrated solution is added to a 15% ethanol aqueous solution with a volume ratio equivalent to 80 times the volume of the concentrated solution, dispersed evenly, centrifuged, and the supernatant is collected, and the supernatant is passed through a D101 macroporous adsorption resin chromatography column, The amount of dry macroporous adsorbent resin is calculated according to the mass ratio of the above concentrated solution to 7:1, the flow rate of the upper column is 2BV / h, and the effluent is discarded; then it is eluted with a volume concentration of 35% ethanol aqueous solution, and th...

Embodiment 2

[0022] The total saponin extract of Chonglou is extracted by the following method:

[0023]Soak the chrysanthemum powder passed through a 5-mesh sieve with 4 mass times the volume ratio of 70% ethanol aqueous solution for 1 hour, heat and reflux extraction 3 times, each time for 2 hours, filter, combine the extracts and concentrate to 1% of the weight of the chrysanthemum part / 6, the concentrated solution is added to the 30% ethanol aqueous solution with a volume ratio equivalent to 50 times of the concentrated solution volume, dispersed evenly, centrifuged, and the supernatant is collected, and the supernatant is subjected to ADS-17 macroporous adsorption resin chromatography column, the amount of dry macroporous adsorbent resin is calculated according to the mass ratio of 4:1 with the above-mentioned concentrated solution, the flow rate of the upper column is 1BV / h, and the effluent is discarded; then it is eluted with a volume concentration of 30% ethanol aqueous solution, ...

Embodiment 3

[0025] The total saponin extract of Chonglou is extracted by the following method:

[0026] Soak the chrysanthemum powder passed through a 5-mesh sieve with 10 mass times the volume ratio of 80% ethanol aqueous solution for 3 hours, heat and reflux extraction twice, each time for 3 hours, filter, combine the extracts and concentrate to 1% of the weight of the chrysanthemum part / 3, add the concentrated solution to a volume ratio of 1% ethanol aqueous solution equivalent to 100 times the volume of the concentrated solution, disperse evenly, centrifuge, collect the supernatant, and pass the supernatant through AB-8 macroporous adsorption resin chromatography column, the amount of dry macroporous adsorbent resin is calculated according to the mass ratio of 10:1 with the above-mentioned concentrated solution, the flow rate of the upper column is 3BV / h, and the effluent is discarded; then it is 40% ethanol aqueous solution for elution with a volume concentration of 40%, and the flow...

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Abstract

The invention discloses a traditional Chinese medicine composition for resisting a liver cancer and a lung cancer. The traditional Chinese medicine composition is prepared from a rhizoma paridis total saponin extract, a curcuma extract and a dioscorease rhizome extract of which the mass ratio is 1:(10-20):(1-10). An in-vitro MTT process activity test proves that the traditional Chinese medicine composition disclosed by the invention has a growth inhibition effect on an LA795 lung cancer cell line and an HepG2 hepatoma cell line; IC50 respectively can be up to below 20mg / mL (dose). An in-vivo experiment proves that the traditional Chinese medicine composition disclosed by the invention has a significant growth inhibition effect on mice T739 lung cancer metastasis in mice, an HepA liver cancer and an H22 lung cancer, and the tumor control rates respectively can be up to 53%, 55% and 57%. Compared with component administration of components forming the composition, the tumor control effect of the composition disclosed by the invention has a synergistic enhancement effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for resisting liver cancer and lung cancer and a preparation method thereof, belonging to the technical field of traditional Chinese medicine Background technique [0002] The traditional Chinese medicine Chonglou is the dried rhizome of Paris polyphylla Smith var. It has the effect of relieving swelling and pain, cooling liver and relieving convulsions. It is used to treat boils, carbuncles, sore throat, poisonous snake bites, bruises, and convulsions caused by cool wind. Main constituent medicines such as tablets. Modern pharmacological studies have shown that Chonglou has cytotoxic activity, antibacterial and anti-inflammatory, analgesic, hemostatic, sedative, anti-early pregnancy, spermicidal, and effects on the respiratory system and cardiovascular system, etc. It is clinically used in the treatment of pulmonary diseases, functional Uterine hemorrhage, lymph node tuberculosis ul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00
Inventor 高文远李红法刘振满淑丽张瑶
Owner TIANJIN UNIV
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