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Gastrodia elata film coated micro-pill preparation and preparation method thereof

A technology of film coating and pellets, which is applied in the field of pharmaceuticals, can solve the problems of unfavorable long-term storage and use, strong hygroscopicity, poor stability, etc., and achieve the effects of overcoming instability, less irritation, and improving moisture-proof performance

Inactive Publication Date: 2014-07-23
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a Gastrodia elata film-coated pellet preparation and its preparation method, which can overcome the problems of strong hygroscopicity, poor stability, and unfavorable long-term storage and use of the existing Gastrodia elata preparations.

Method used

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  • Gastrodia elata film coated micro-pill preparation and preparation method thereof
  • Gastrodia elata film coated micro-pill preparation and preparation method thereof

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Embodiment 1

[0035] Embodiment 1 of the present invention: the preparation method of Gastrodia elata film-coated pellet preparation

[0036] (1) Preparation of Gastrodia elata pellets: Dry Gastrodia elata powder and filler separately, and pass through a 100-mesh sieve; take 20g Gastrodia elata powder, 27.5g microcrystalline cellulose and 2.5g lactose and mix evenly, add the concentration of 5% by mass % PEG6000 aqueous solution was used as binder to prepare soft material; the soft material was prepared by extrusion spheronization process to obtain pellets; the extrusion frequency of extrusion spheronization process was 20 Hz, the spheronization frequency was 20 Hz, and the spheronization time was 8 min; Dry in an oven at ℃ for 3 hours, and sieve the pellets with a particle size of 18-35 mesh for subsequent use;

[0037] (2) Film-coat the pellets: use water as a solvent, dissolve Opadry® 200 solid powder, stir for 30 minutes, and prepare a film-coating solution with a concentration of 10% b...

Embodiment 2

[0038] Embodiment 2 of the present invention: the preparation method of Gastrodia elata film-coated pellet preparation

[0039] (1) Preparation of Gastrodia elata pellets: Dry Gastrodia elata powder and filler separately, and pass through a 100-mesh sieve; take 25g Gastrodia elata powder, 20g microcrystalline cellulose and 5g lactose and mix evenly, add 10% mass percentage concentration of PEG6000 aqueous solution was used as a binder to prepare soft material; the soft material was prepared by extrusion spheronization process to obtain pellets; the extrusion frequency of extrusion spheronization process was 30 Hz, the spheronization frequency was 25 Hz, and the spheronization time was 10 min; Dry in an oven for 3 hours, and sieve the pellets with a particle size of 18-35 mesh for subsequent use;

[0040] (2) Film-coat the pellets: use water as a solvent, dissolve Opadry® 200 solid powder, stir for 45 minutes, and prepare a film-coating solution with a concentration of 15% by m...

Embodiment 3

[0041] Embodiment 3 of the present invention: the preparation method of Gastrodia elata film-coated pellet preparation

[0042] (1) Preparation of Gastrodia elata pellets: Dry Gastrodia elata powder and filler separately, and pass through a 100-mesh sieve; take 30g Gastrodia elata powder, 17.5g microcrystalline cellulose and 2.5g lactose and mix evenly, add the mass percentage concentration of 15 % PEG6000 aqueous solution was used as binder to prepare soft material; the soft material was prepared by extrusion spheronization process to obtain pellets; the extrusion frequency of extrusion spheronization process was 30 Hz, the spheronization frequency was 30 Hz, and the spheronization time was 10 min; Dry in an oven at ℃ for 3 hours, and sieve the pellets with a particle size of 18-35 mesh for subsequent use;

[0043](2) Film-coat the pellets: use water as a solvent, dissolve Opadry® 200 solid powder, stir for 45 minutes, and make a film-coating solution with a mass percentage c...

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Abstract

The invention discloses a gastrodia elata film coated micro-pill preparation and a preparation method thereof. The gastrodia elata film coated micro-pill preparation is characterized by comprising a pill core and a coating layer, wherein the pill core comprises the following raw materials in parts by weight: 40-60 parts of gastrodia elata, 30-70 parts of filler and proper adhesive; the ratio of the weight of the film coating to the total weight of gastrodia elata powder and filler is (0.15-0.25):1. The gastrodia elata micro-pill is prepared by adopting an extrusion rolling method, and then related film coating materials are screened. Compared with the commercially available ordinary gastrodia capsule, the finally obtained gastrodia elata film coated micro-pill preparation has excellent humidity resistance and good stability.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a Gastrodia elata film-coated pellet preparation and a preparation method thereof. Background technique [0002] Gastrodia elata is the dry tuber of the orchid plant Gastrodia elata. Gastrodia elata, as a precious Chinese medicinal material, has the effect of calming the liver and calming the wind. It is mainly used for dizziness, headache, numbness of limbs, etc. caused by liver wind disturbance, and is widely used clinically. At present, most of Gastrodia elata products on the market are capsules, but these products have problems such as strong hygroscopicity and poor stability. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a Gastrodia elata film-coated pellet preparation and its preparation method, which can overcome the problems of strong hygroscopicity, poor stability, unfavorable long-term storage and use of the exis...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/16A61K9/48A61P25/00
Inventor 王慧娟周英石洋潘博文
Owner GUIZHOU UNIV
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