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Pharmaceutical composition for local anaesthesia as well as preparation method and application thereof

A technology of local anesthesia and composition, applied in the directions of drug combination, anesthetic, pharmaceutical formula, etc., can solve the problems of short-lived body, neurotoxicity of capsaicin, potential safety hazard, etc., and achieves small side effects, excellent anesthetic effect, and good clinical application. Foreground effect

Inactive Publication Date: 2014-07-23
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lidocaine is a common local anesthetic drug with good anesthesia effect, but because it blocks sensory nerve and motor nerve at the same time, it is accompanied by complications such as paralysis and hypotension while anesthesia and analgesia
[0003] QX-314 is a quaternary ammonium derivative of the local anesthetic lidocaine, which can produce long-lasting local anesthesia, but its own anesthetic potency is very low, and its onset is very slow
[0004] Combining capsaicin with QX-314 can effectively improve its anesthetic effect and produce a fast-acting selective sensory block. However, capsaicin will cause short-term and severe pain in the body, and the application of high concentrations of capsaicin has neurological effects. Toxicity, potential safety hazard

Method used

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  • Pharmaceutical composition for local anaesthesia as well as preparation method and application thereof
  • Pharmaceutical composition for local anaesthesia as well as preparation method and application thereof
  • Pharmaceutical composition for local anaesthesia as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 local anesthesia pharmaceutical composition of the present invention

[0025] 1. Raw materials

[0026] QX-314, isoflurane: commercially available.

[0027] 2, prepare medicine of the present invention

[0028] (1) Dissolve 1 g of QX-314 and 0.5 g of nano-gold in normal saline, and set the volume to 100 ml to obtain an aqueous solution with a concentration of QX-314 of 1% and a concentration of nano-gold of 0.5%.

[0029] (2) Dissolve 4 ml of isoflurane in 30% fat emulsion, and set the volume to 100 ml to obtain emulsified isoflurane with an isoflurane concentration of 4%.

[0030] (3) Get the aqueous solution prepared by the equal volume step (1) and the fat emulsion obtained by the step (2), and mix evenly to obtain a QX-314 concentration of 0.5%, a nano-gold concentration of 0.25%, and an isoflurane concentration of 2% solution.

Embodiment 2

[0031] Embodiment 2 Preparation of local anesthesia pharmaceutical composition of the present invention

[0032] 1. Raw materials

[0033] QX-314, isoflurane: commercially available.

[0034] 2, prepare medicine of the present invention

[0035] (1) Dissolve 4g of QX-314 and 4g of nano-gold in normal saline, and set the volume to 100ml to obtain an aqueous solution with QX-314 concentration of 4% and nano-gold concentration of 4%.

[0036] (2) Dissolve 1 ml of isoflurane in 30% fat emulsion, and set the volume to 100 ml to obtain emulsified isoflurane with an isoflurane concentration of 1%.

[0037] (3) Get the aqueous solution prepared by the equal volume step (1) and the fat emulsion prepared by the step (2), and mix them evenly to obtain a QX-314 concentration of 2%, a nano-gold concentration of 2%, and an isoflurane concentration of 2%. 0.5% solution.

Embodiment 3

[0038] Embodiment 3 Preparation of local anesthesia pharmaceutical composition of the present invention

[0039] 1. Raw materials

[0040] QX-314, isoflurane: commercially available.

[0041] 2, prepare medicine of the present invention

[0042] (1) Dissolve 2g of QX-314 and 2g of nano-gold in normal saline, and set the volume to 100ml to obtain an aqueous solution with a QX-314 concentration of 2% and a nano-gold concentration of 2%.

[0043] (2) Dissolve 1 ml of isoflurane in 30% fat emulsion, and set the volume to 100 ml to obtain emulsified isoflurane with an isoflurane concentration of 1%.

[0044] (3) get the aqueous solution that equal volume step (1) makes and the fat emulsion that step (2) makes, mix, promptly get QX-314 concentration be 1%, nano-gold concentration is 1%, isoflurane concentration is 0.5% solution.

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Abstract

The invention discloses a pharmaceutical composition for local anaesthesia. The pharmaceutical composition comprises the following components in proportion: 0.5-2 parts of QX-314, 0.25-2 parts of nanogold, 0.5-4 volume parts of isoflurane. The invention further discloses a preparation method and application of the pharmaceutical composition for local anaesthesia. The composition disclosed by the invention has good anesthetic effect, is safe and effective, and excellent in clinical application prospect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for local anesthesia, a preparation method and application thereof. Background technique [0002] Anesthesia is the use of drugs or other methods to temporarily deprive the patient of the whole or part of the sensation in order to achieve painless surgical treatment. Lidocaine is a common local anesthetic drug with good anesthesia effect, but because it blocks sensory nerve and motor nerve at the same time, it is accompanied by complications such as paralysis and hypotension while anesthesia and analgesia. [0003] QX-314 is a quaternary ammonium salt derivative of local anesthetic lidocaine, which can produce long-lasting local anesthetic effect, but its anesthetic potency is very low, and its onset is very slow. [0004] Combining capsaicin with QX-314 can effectively improve its anesthetic effect and produce a fast-acting selective sensory block. However, capsaicin will cause short-term and seve...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61P23/02A61K31/167A61K31/08
Inventor 周诚李涛刘进
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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