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Composition for treating chromic complications of diabetes mellitus

A composition and technology of diabetes, applied in the direction of drug combination, urinary system diseases, metabolic diseases, etc., to achieve the effect of improving high blood pressure and preventing chronic complications of diabetes

Inactive Publication Date: 2014-07-16
JINZHOU BOZE PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effects of the above two aspects make sorbitol accumulate in a large amount in the tissue. As a very polar compound, it cannot freely enter and leave the cell, resulting in a hypertonic state in the cell, thereby causing the osmotic edema of the cell. At the same time, the sorbitol in the cell A large amount of alcohol accumulation can also reduce the activity of Na+, K+-ATP enzymes, and the loss of inositol in cells, which will lead to the damage of cell metabolism and function, and then diabetes complicated disease and other organ diseases

Method used

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  • Composition for treating chromic complications of diabetes mellitus
  • Composition for treating chromic complications of diabetes mellitus
  • Composition for treating chromic complications of diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] This kind of traditional Chinese medicine composition for treating diabetes for oral administration, the raw material of making active ingredient is by following weight:

[0055] 1000g of mulberry leaves, add 8-12 times the amount of water, decoct in water, heat at 60-100°C, stir for 1-2 hours, filter, centrifuge the filtrate at high speed, filter it with a polysulfoneamide filter membrane, put the filtrate at a temperature of 60-110°C, vacuum Under the condition of 0.08-0.09MPa, it is concentrated under reduced pressure to a clear paste with a relative density of about 0.8-1.5 (60°C), with appropriate amount of auxiliary materials, the drying temperature of the material is 75-100°C, the atomization pressure is 0.06-0.09MPa, and the spray frequency speed is 30 ~40kg / h, spray-dried to obtain the extract of mulberry leaf extract, ready for use;

[0056] 250g of fresh dendrobium was washed by high-pressure spraying, cut into 1cm pieces, and mixed with purified water to mak...

Embodiment 2

[0059] Preparation of low-temperature freeze-dried dendrobium homogenate:

[0060] Dendrobium 1000g

[0061] Take the Dendrobium medicinal material and wash it with high-pressure spray, cut it into small pieces of 0.5-1cm, add 10 times the amount of ethanol, and extract under reflux at no more than 50°C; recover the ethanol at a low temperature of no more than 50°C from the extract, concentrate it to an appropriate amount, subpackage, and freeze-dry Instantly.

[0062] Store at low temperature, dissolve in purified water and take orally immediately before use.

Embodiment 3

[0064] Mulberry leaves 2000g

[0065] Dendrobium 1000g

[0066] 2000g mulberry leaves, add 8-12 times the amount of water, decoct in water, heat at 60-100°C, stir for 1-2 hours, filter, centrifuge the filtrate at high speed, filter with polysulfoneamide filter membrane, concentrate to 3000ml, set aside

[0067] Take the dendrobium medicinal material and wash it with high-pressure spray, cut it into small pieces of 0.5-1cm, add 10 times the amount of ethanol, and extract it under reflux at no more than 50°C; recover the ethanol at a low temperature of no more than 50°C from the extract, make the concentrated solution to an appropriate amount, and mix it with the above-mentioned mulberry leaves The extract is subpackaged and freeze-dried.

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Abstract

The invention relates to an aldose reductase inhibitor for treating chromic complications of diabetes mellitus after being taken orally. The composition comprises natural medicines with aldose reductase inhibition action and at least one medicine with alpha-glycosidase inhibition action and has double actions containing aldose reductase inhibition action and alpha-glycosidase inhibition action. Accidental clinical and pharmacological discovery proves that the composition has the effect of reducing postprandial blood sugar by glycosidase inhibition action and is capable of protecting the retina of a patient with diabetes mellitus, delaying the progress of diabetes mellitus caused senile dementia, and relieving the symptoms of the diabetes mellitus caused senile dementia by virtue of aldose reductase inhibition action.

Description

technical field [0001] The invention relates to an aldose reductase inhibitor for oral treatment of diabetic complications, which belongs to the field of natural medicines. Background technique [0002] Aldose reductase exists in tissues and organs such as human nerves, red blood cells, lenses, and retinas, and catalyzes the formation of sorbitol from glucose in the blood in the polyol pathway. Sorbitol itself is difficult to pass through the cell membrane due to its strong polarity, and it will form accumulation in the cell, which will change the permeability of the cell membrane and make the Na in the cell + -K + - ATPase activity decreases, resulting in loss of inositol, resulting in damage to cell metabolism and function. Aldose reductase is a key rate-limiting enzyme of the polyol pathway. When blood glucose concentration is maintained at normal physiological level, it is not activated, and its affinity for glucose is low, and glucose is rarely converted into sorbito...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K36/8984A61P3/10A61P9/10A61P25/28A61P13/12
Inventor 不公告发明人
Owner JINZHOU BOZE PHARMA TECH DEV
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