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Hydronopyl triethyl ammonium iodide preparation method and application

A technology of hydrogenated nopyl triethyl ammonium iodide and hydrogenated nopyl iodoalkane, applied in the field of medicine, can solve the problems of no inhibition of tumor cell growth, no anti-cancer activity and the like

Inactive Publication Date: 2014-07-09
JIANGXI AGRICULTURAL UNIVERSITY
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Problems solved by technology

However, this study proved that α-humulene has anticancer activity on the above cancer cells, while other compounds in essential oils have no activity of inhibiting the growth of tumor cells, that is, α-pinene and β-pinene have no anticancer activity

Method used

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  • Hydronopyl triethyl ammonium iodide preparation method and application
  • Hydronopyl triethyl ammonium iodide preparation method and application
  • Hydronopyl triethyl ammonium iodide preparation method and application

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Embodiment Construction

[0011] Below in conjunction with the examples, the specific implementation of the present invention will be further described in detail. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0012] A preparation method of notyl triethylammonium iodide, comprising the following steps:

[0013] 1) In a 500ml three-necked flask equipped with a mechanical stirrer and a reflux condenser, put 100ml of acetone, 0.2mol of nobyl chloride hydrochloride and 35g of sodium iodide, stir, and heat to reflux. After 8 hours, samples were taken for GC analysis. After the conversion of alcohol is complete, cool to room temperature and filter to remove salt. After treatment, a yellowish hydronobyl iodide was obtained.

[0014] 2) Install a reflux condenser on the 250ml ground-mouth Erlenmeyer flask, place the Erlenmeyer flask on a magnetic stirrer, add 0.1mol hydronobyl iodide, 45ml acetonitrile and 0.11mol trie...

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Abstract

The invention relates to a preparation method of hydronopyl triethyl ammonium iodide, and an application of the prepared hydronopyl triethyl ammonium iodide in preparation of an inhibitor for treating tumor. The compound has obvious inhibition effect for tumor cells, and the preparation method of hydronopyl triethyl ammonium iodide is characterized in that hydronopyl chlorine is reacted to sodium iodide to prepare hydronopyl iodine, and the hydronopyl iodine is reacted to triethylamine to obtain hydronopyl triethyl ammonium iodide. The prepared hydronopyl triethyl ammonium iodide has median inhibitory concentration 50 (IC50 ) value of human lung cancer H460 cells, human breast cancer MCF7 cells, human liver cancer SMMC7721 cells, human stomach cancer MK-45 cells as 8.3mum g / ml, 13.25mum g / ml, 2.28mum g / ml and 1.27mum g / ml, which are most basically less than 10 mum g / ml, and partially achieves the requirements of SFDA antitumor drug pharmacodynamics guidance principle, and expresses good antineoplastic activity.

Description

technical field [0001] The invention relates to a preparation method of notyltriethylammonium iodide and the application of notyltriethylammonium iodide as a human tumor inhibitor, belonging to the field of medicine. Background technique [0002] The source of turpentine is the turpentine secreted by the trunk of Pinaceae Pinus, and the volatile oil obtained after distillation of the turpentine is turpentine. The main components of turpentine are α-pinene and β-pinene. my country is very rich in pine resources, and the area of ​​pine forests is about 1-6 million km 2 , the annual output of turpentine is about 80,000 to 100,000 tons, second only to the United States, ranking second in the world, but there is still a certain gap compared with developed countries in the variety and utilization of deeply processed products. The main components of essential oil extracted from balsam fir leaves are β-pinene (31%), α-pinene (16%), δ-3-carene (20%), borneol acetate (7%), α-pinene ...

Claims

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Application Information

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IPC IPC(8): C07C209/12C07C211/63A61P35/00
Inventor 王宗德赵玲华肖转泉范国荣陈金珠陈尚钘王鹏
Owner JIANGXI AGRICULTURAL UNIVERSITY
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