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Collagen polypeptide burn repair film and preparation method thereof

A technology of collagen peptides and raw materials, applied in the field of biomedical materials, to achieve the effects of increasing diversity, preventing body fluid loss, and reducing infection

Inactive Publication Date: 2014-07-02
SICHUAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a new collagen polypeptide burn repair film, which can promote wound healing through the release of collagen polypeptide and baicalin, so as to solve the current problems in burn wound treatment. The collagen polypeptide burn repair film of the present invention It has good biocompatibility, air permeability, can absorb the exudate of the wound, keep the wound dry and prevent infection so as to promote wound healing and reduce scarring

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] In a clean and dry beaker, add 0.1 part of collagen peptide, 0.1 part of soluble starch, 0.5 part of Scutellaria baicalensis extract, 2 parts of water, stir well to dissolve. Add 0.5 parts of sodium carboxymethyl cellulose to another beaker, then add 10 parts of ionic water, stir mechanically in a water bath at 40°C until the mixture is uniform and form a transparent colloidal solution, then add 2 parts of pentadiene Aldehyde, 3 parts glycerol, stir for 5 minutes to mix well.

[0027] Pour the mixed solution in the first beaker into the second beaker, and continue mechanical stirring in a water bath at 40°C until a uniform viscous jelly is obtained.

[0028] Evenly spread the jelly on the dry and clean template to form a jelly layer with uniform thickness and smooth surface, bake in a constant temperature oven at 60°C for 1.5 hours, and peel off the film to obtain the collagen polypeptide burn repair film.

Embodiment 2

[0030] In a clean and dry beaker, add 0.3 parts of collagen peptides, 0.5 parts of soluble starch, 0.2 parts of Scutellaria baicalensis extract, add 3 parts of water, stir well to dissolve. Add 2 parts of sodium carboxymethyl cellulose to another beaker, then add 15 parts of ionic water, stir mechanically in a water bath at 35°C until the mixture is uniform and form a transparent colloidal solution, then add 2 parts of pentadiene Aldehyde, 3 parts glycerol, stir for 5 minutes to mix well.

[0031] Pour the mixed solution in the first beaker into the second beaker, and continue mechanical stirring in a water bath at 35°C until a uniform viscous jelly is obtained.

[0032] Evenly spread the jelly on the dry and clean template to form a jelly-like layer with uniform thickness and smooth surface, bake in a constant temperature oven at 60°C for 1.8 hours, and peel off the film to obtain the collagen polypeptide burn repair film.

Embodiment 3

[0034] In a clean and dry beaker, add 0.5 part of collagen peptide, 0.3 part of soluble starch, 0.1 part of Scutellaria baicalensis extract, add 2 parts of water, stir well to dissolve. Add 1 part of sodium carboxymethylcellulose to another beaker, then add 10 parts of ionic water, stir mechanically in a water bath at 45°C until the mixture is uniform and form a transparent colloidal solution, then add 1 part of pentadiene Aldehyde, 3 parts glycerol, stir for 5 minutes to mix well.

[0035] Pour the mixed solution in the first beaker into the second beaker, and continue mechanical stirring in a water bath at 45°C until a uniform viscous jelly is obtained.

[0036] Evenly spread the jelly on the dry and clean template to form a jelly layer with uniform thickness and smooth surface, bake in a constant temperature oven at 60°C for 1.5 hours, and peel off the film to obtain the collagen polypeptide burn repair film.

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Abstract

The invention relates to a preparation method of a collagen polypeptide burn repair film, and belongs to the field of biomedical materials. The collagen polypeptide burn repair film takes collagen polypeptide, sodium carboxymethyl cellulose, glutaraldehyde and starch to form a base framework structure of the film, glycerol is added as a humectant to control humidity of the film; then, scutellaria baicalensis extract is added; finally, the uniformly-fixed pasty mixed liquor is poured into a mould for being formed, and dried in an oven at a constant temperature; the film is stripped to obtain the collagen polypeptide burn repair film with good biocompatibility and antibacterial property.

Description

technical field [0001] The invention relates to a collagen polypeptide burn repair film and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] The research on skin repair materials is the exploration of skin substitute materials. Research on skin substitute materials can be further divided into two main lines of exploration: temporary skin substitute materials and permanent skin substitute materials. The repair materials can be divided into autologous skin grafts, autologous skin flaps, and autologous skin substitutes. Composite tissue flaps, etc. Every milestone breakthrough in skin repair starts with the renewal of understanding concepts, is marked by the innovation of technical means, and matures with the improvement of the composition or structure of repair materials. [0003] The main component of the dermis is collagen, and collagen contains a large amount of amino acids, which has attracted more and more atten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/36A61L27/54A61L27/50
Inventor 舒子斌蒋莹杨华丁胜利刘静毕林曼
Owner SICHUAN NORMAL UNIV
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