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A kind of bionic composite patch and its preparation method and application

A patch, the other side of the technology, applied in the field of bionic regenerative repair absorbable degradable patch preparation, can solve the problems of collagen sponge not soft, poor tissue attachment performance, calcification, etc.

Active Publication Date: 2016-05-18
GUANGZHOU SHUIWUSHA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many defects in its products that affect the performance of its functions. For example, the collagen sponge product is not soft and has poor adhesion to tissues. In order to obtain certain mechanical properties, a cross-linking agent is added, which is toxic to tissues and easily leads to calcification.

Method used

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  • A kind of bionic composite patch and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Preparation of cell induction layer:

[0018] Dissolve 2g PDLLA (Mη=80,000) and 0.48g PLLA (Mη=80,000) in 30ml ethyl acetate, then mix into lecithin, the mixing ratio (mass percentage) of it and polylactic acid material is 4 / 100, stir for 24h . The polymer solution was evenly poured into the mold, and when the film was formed, vacuum was applied at 45°C for 24 hours to prepare the isolation film. Laser drilling on the film: the hole diameter is 150 μm, the distance between holes is 200 μm, the depth is 0.1 mm, and the thickness is 0.3 mm.

[0019] 2. Cell anti-seepage layer preparation: 2gPDLLA (Mη=80,000) and 0.48gPLLA (Mη=80,000) were dissolved in 50ml of dichloromethane, stirred for 24 hours, then mixed with lecithin, and mixed with polylactic acid material The ratio (mass percentage) is 4 / 100. In an environment with a humidity of 45-65% and a temperature of 18-28° C., the electrospun membrane is obtained by electrospinning with an electrospun diameter of 150 n...

Embodiment 2

[0024] 1. Preparation of cell induction layer:

[0025] Dissolve 3gPDLLA (Mn=80,000) and 0.41gPLLA (Mn=80,000) in 30ml ethyl acetate, then mix into lecithin, its mixing ratio (mass percentage) with polylactic acid material is 13 / 100 respectively, stir 24h. Pour the polymer solution evenly into the mold, and when the film is formed, vacuumize at 45° C. for 24 hours to prepare a separator with a hole on one side and a smooth side on the other. Laser drilling on the film: the hole diameter is 100 μm, the distance between holes is 200 μm, the depth is 0.1 mm, and the thickness is 0.3 mm.

[0026] 2. Cell anti-seepage layer preparation: 3gPDLLA (Mη=80,000) and 0.41gPLLA (Mη=80,000) were dissolved in 50ml of dichloromethane, stirred for 24 hours, then mixed into lecithin, and its mixing with polylactic acid material The ratio (mass percentage) was 13 / 100 respectively, and stirred for 24 hours. In an environment with a humidity of 45-65% and a temperature of 18-28° C., the electro...

Embodiment 3

[0030] 1. Preparation of cell induction layer:

[0031] Dissolve 3gPDLLA (Mn=80,000) and 0.41gPLLA (Mn=80,000) in 30ml ethyl acetate, then mix into lecithin, its mixing ratio (mass percentage) with polylactic acid material is 9 / 100 respectively, stir 24h. Pour the polymer solution evenly into the mold, and when the film is formed, vacuumize at 45° C. for 24 hours to prepare a separator with a hole on one side and a smooth side on the other. . Laser drilling on the film: the hole diameter is 100 μm, the distance between the holes is 200 μm, and the depth is 0.1 mm. The thickness is 0.3mm.

[0032] 2. Cell anti-seepage layer preparation: 3gPDLLA (Mη=80,000) and 0.41gPLLA (Mη=80,000) were dissolved in 50ml of dichloromethane, stirred for 24 hours, then mixed into lecithin, and its mixing with polylactic acid material The ratio (mass percentage) was 9 / 100 respectively, and stirred for 24 hours. In an environment with a humidity of 45-65% and a temperature of 18-28° C., the el...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to a biomimetic composite patch. The biomimetic composite patch mainly comprises an isolating membrane, wherein holes are evenly distributed in two sides of the isolating membrane respectively; a cell induction layer is formed at one side of the isolating membrane; an outer layer space is formed at the other side of the isolating membrane; an induction space is formed in the middle of the isolating membrane; an impermeable layer covers the outer layer space, so as to provide a space for two-way growth of cells. The patch can absorb an electrospinning patch formed by a degradable material and a function factor complex. The invention provides a preparation method of the patch and use of the patch in the aspects of pasting, sealing, blocking, stopping bleeding, isolating, repairing and preventing adhesion of defective tissues in a surgical operation. The patch also can be used as a controlled release carrier of a medicament and a tissue engineering scaffold material.

Description

technical field [0001] The invention relates to a preparation method and application of a bionic regenerative repair absorbable degradable patch. Background technique [0002] In surgical operations, it is often necessary to seal, repair and prevent adhesions to defects and damaged tissues. At present, there are two types of tissue patches at home and abroad. One is obtained from biological corpses and has the immunogenic characteristics of xenogeneic animals. Biological safety is still not guaranteed, especially when animal-borne infectious diseases occur, and such materials often have abnormal reactions when implanted into the human body. The other is a patch made of synthetic material that acts as a physical barrier. Existing products include film and gel products of carboxymethyl cellulose, chitosan, collagen and fibrin glue. These products play a positive role in sealing, repairing and preventing adhesion of damaged tissues to a certain extent. However, there are man...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/18A61L27/56A61L27/50A61L31/06A61L31/14A61F2/02A61B17/00
Inventor 朱晓明张雪莲
Owner GUANGZHOU SHUIWUSHA BIOTECH CO LTD
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