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Pharmaceutical composition for treating diabetes and application thereof

A composition and diabetes technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of content loss and limitation of drug efficacy, and achieve the pharmacological effects of lipid-lowering and hypoglycemic effects and significant pharmacological effects Effect

Inactive Publication Date: 2014-07-02
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since catalpol and oligosaccharides, the main hypoglycemic active ingredients of fresh rehmannia glutinosa, are easily affected by temperature and glucosidase, their content loss is relatively serious in the traditional process, which limits the efficacy of the drug to a certain extent.

Method used

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  • Pharmaceutical composition for treating diabetes and application thereof
  • Pharmaceutical composition for treating diabetes and application thereof
  • Pharmaceutical composition for treating diabetes and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The raw materials are weighed according to the following proportions: 1 part of Coptidis rhizome, 20 parts of fresh rehmannia glutinosa.

[0042] (1) Take Coptis chinensis, add 5 times the volume (volume / weight, in L / Kg) of 95% ethanol to extract 3 times, each time for 3 hours, extract the solvent under reduced pressure, concentrate, dry, and pulverize to obtain the extract ,spare;

[0043] (2) Take fresh rehmannia glutinosa, add 5 times the volume of 95% ethanol, immerse and extract once at room temperature, 12 hours each time, combine the extracts, filter, concentrate, dry, and pulverize to obtain the extract, and set aside;

[0044] (3) Pass the above-mentioned dry powder extract through an 80-mesh sieve, add appropriate amount of powdered sugar, granulate, and pack to obtain the pharmaceutical granule of the present invention.

Embodiment 2

[0046] The raw materials are weighed according to the following proportions: 1 part of Coptidis rhizome, 8 parts of fresh rehmannia glutinosa.

[0047] (1) Take Coptis chinensis, add 20 times the volume (volume / weight, in L / Kg) of 70% ethanol to extract twice, each time for 1 hour, extract the solvent under reduced pressure, concentrate, dry, and pulverize to obtain the extract ,spare;

[0048] (2) Take fresh Rehmannia glutinosa, add 40 times the volume of 10% ethanol, soak and extract at room temperature twice, 6 hours each time, combine the extracts, filter, concentrate, dry, and pulverize to obtain the extract, and set aside;

[0049] (3) The above-mentioned dry powder extract is added with appropriate amount of sucrose and dextrin, mixed evenly, made into granules, dried, and then prepared into capsules according to the conventional process.

Embodiment 3

[0051] The raw materials are weighed according to the following proportions: 1 part of Coptidis rhizome, 10 parts of fresh rehmannia glutinosa.

[0052](1) Take Coptis chinensis, add 20 times the volume (volume / weight, in L / Kg) of 70% ethanol to extract twice, each time for 1 hour, extract the solvent under reduced pressure, concentrate, dry, and pulverize to obtain the extract ,spare;

[0053] (2) Take fresh rehmannia glutinosa, add 20 times the volume of 50% ethanol, immerse and extract at room temperature 4 times, 3 hours each time, combine the extracts, filter, concentrate, dry, and pulverize to obtain the extract, and set aside;

[0054] (3) Add appropriate amount of sucrose and dextrin to the above-mentioned dry powder extract, mix well, make granules, dry, and then prepare capsules according to the conventional process.

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Abstract

The invention provides a pharmaceutical composition for treating diabetes and application thereof. The pharmaceutical composition is mainly prepared from the following raw materials in parts by weight: 1 part of coptis chinensis and 0.1-20 parts of fresh rehmannia; the pharmaceutical composition is prepared by the following steps: extracting the coptis chinensis through steps of performing ethanol reflux extraction, and concentrating and drying an extracting solution to obtain a coptis chinensis extract; extracting the fresh rehmannia through steps of performing ethanol reflux extraction, and concentrating and drying an extracting solution to obtain a fresh rehmannia extract; then mixing the coptis chinensis extract with the fresh rehmannia extract. The invention provides application of the pharmaceutical composition in preparing a medicine for treating the diabetes as well. The pharmaceutical composition disclosed by the invention has a significant advantage in the transfer rate of such main active ingredients as catalpol, stachyose and berberine and the like compared with Qianjin optis chinensis pills prepared by a conventional process; moreover, pharmacological experiments prove that the medicine disclosed by the invention has significant pharmacological effects of regulating fat and reducing sugar, and the pharmacological effects are remarkably better than that of a conventional process product.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition and its application, in particular to a pharmaceutical composition for treating diabetes and its application. Background technique [0002] Diabetes is a chronic progressive disease. In recent years, it has been growing rapidly and becoming younger. In 2010, there were more than 50 million people with diabetes in my country, with an average age of 45 years. Diabetes mellitus is characterized by chronic hyperglycemia accompanied by disturbances in carbohydrate, fat, and protein metabolism due to defects in insulin secretion and / or action. Among them, type Ⅱ diabetes accounts for more than 90% of all diabetic patients. [0003] At present, the drugs used clinically to treat diabetes are mainly chemical drugs, such as metformin, angiotensin-converting enzyme inhibitors, insulin sensitizers, etc., but long-term use has serious side...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P3/10
Inventor 张铁军田成旺朱雪瑜王丽莉龚苏晓廖茂梁许浚孙卫
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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