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Pharmaceutical composition for resisting chemotherapy induced bone marrow suppression and application thereof

A technology of myelosuppression and composition, applied in the field of chemotherapeutic myelosuppression, to prevent leukopenia, increase the number, and improve the effect of chemotherapy

Inactive Publication Date: 2014-07-02
于法周
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] By searching the existing technologies at home and abroad, it is found that there is no literature report on the use of quercetin or its derivatives to treat myelosuppression caused by chemotherapy drugs

Method used

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Examples

Experimental program
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Embodiment

[0020] Example Antagonistic study of quercetin on chemotherapy-induced myelosuppression

[0021] Mouse ascites tumor S180 cells were cultured in 1640 medium, 37°C, 5% CO 2 Under conventional culture, subculture once every two days on average, and prepare a density of 3.0×10 with normal saline in the logarithmic growth phase. 7 cells / ml single cell suspension, injected into the abdominal cavity of KM mice under aseptic conditions, the abdominal cavity of the mice was obviously swollen 7 days after inoculation, at this time, they were killed by dislocation and put into a beaker filled with 75% ethanol After soaking for 2 to 3 minutes, put the sterilized mouse into the ultra-clean workbench, expose the abdomen, extract the ascites with a sterile syringe and put it into a sterile reagent bottle for later use. Count the above ascites with trypan blue, dilute with normal saline, and adjust the number of cells to 2.0×10 7 per ml, inoculated in the right axilla of KM mice weighing 1...

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Abstract

The invention discloses a pharmaceutical composition for resisting chemotherapy induced bone marrow suppression and application thereof. The pharmaceutical composition is prepared from an active ingredient and accessories, wherein the active ingredient comprises quercetin and / or a derivative thereof. The quercetin not only has an antitumor activity but also is capable of significantly improving the quantity of leukocytes after chemotherapy, and especially the quercetin has the bioactivity of increasing the quantity of neutrophils, showing that the quercetin and the derivative thereof are expected to be developed as a medicine for resisting chemotherapy induced bone marrow suppression.

Description

technical field [0001] The invention belongs to the technical field of drugs for chemotherapeutic myelosuppression, and in particular relates to a pharmaceutical composition for resisting chemotherapeutic myelosuppression and its application. Background technique [0002] Leukocytes include neutrophils, eosinophils and basophils. Leukocytes are derived from bone marrow. Clinically, cancer patients often experience bone marrow suppression after receiving drug chemotherapy, so that the number of peripheral blood leukocytes decreased, the number of neutrophils decreased. Neutrophils in human peripheral blood account for about 50-70% of the total number of white blood cells. The increase and decrease of neutrophils directly affect the change of the total number of white blood cells. decrease. The quantitative correlation between the two also shows consistency in meaning, that is, the significance of the increase and decrease of neutrophils is basically the same as that of the ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/675A61P7/00A61P35/00
Inventor 于法周
Owner 于法周
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