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Composition for use in the promotion of intestinal angiogenesis and of nutrient absorption and of enteral feeding tolerance and/or in the prevention and/or treatment of intestinal inflammation and/or in the recovery after intestinal injury and surgery

A technique for angiogenesis and nutrient absorption, applied in a composition for promoting intestinal angiogenesis and nutrient absorption and enteral feeding tolerance and/or preventing and/or treating enteritis, and/or intestinal injury and post-operative recovery It can solve problems such as intolerance, impaired quality of life, and impaired nutrition digestion

Inactive Publication Date: 2014-06-25
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, surgery results in short bowel syndrome, which can lead to permanently impaired nutrient digestion, feeding intolerance, and impaired quality of life

Method used

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  • Composition for use in the promotion of intestinal angiogenesis and of nutrient absorption and of enteral feeding tolerance and/or in the prevention and/or treatment of intestinal inflammation and/or in the recovery after intestinal injury and surgery
  • Composition for use in the promotion of intestinal angiogenesis and of nutrient absorption and of enteral feeding tolerance and/or in the prevention and/or treatment of intestinal inflammation and/or in the recovery after intestinal injury and surgery
  • Composition for use in the promotion of intestinal angiogenesis and of nutrient absorption and of enteral feeding tolerance and/or in the prevention and/or treatment of intestinal inflammation and/or in the recovery after intestinal injury and surgery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0111] Experiments were performed on: Supplemented oligosaccharide mixture which is a mixture of milk oligosaccharides (CMOS) enriched in galactooligosaccharides (demineralised, lactose-depleted whey permeate or DDWP), LC-PUFA (Peanut IV Effects of enoic acid-ARA- and docosahexaenoic acid-DHA-) and Bifidobacterium lactis (BL) and optionally 2'-fucosyllactose (FL) on pups.

[0112] 1. method

[0113] Experimental program

[0114] Experiments were performed in accordance with the Swiss Animal Protection Act (severity level 1) and were approved by the Office Vétérinaire Cantonal (Lausanne, Switzerland, grant numbers 2028 and 2028.1). Reproductor male and virgin female Long-Evans Hooded rats were purchased from Janvier (France), which arrived at the animal care two weeks prior to mating.

[0115] Pregnant females had free access to food (Kliba3437) and water and were housed at constant temperature and humidity and maintained on a 12:12 dark:light cycle. Captive conditions wer...

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Abstract

The invention discloses a composition comprising at least one long chain polyunsaturated fatty acid, at least one probiotic and a mixture of oligosaccharides, said mixture containing at least one N-acetylated oligosaccharide, at least one sialylated oligosaccharide and at least one neutral oligosaccharide, for use in the promotion of intestinal angiogenesis and of nutrient absorption and of enteral feeding tolerance and / or in the prevention and / or treatment of intestinal inflammation, such as necrotizing enterocolis, and / or in the recovery after intestinal injury and / or surgery. This composition is particularly adapted for use in infants, notably preterm infants.

Description

field of invention [0001] The present invention relates to compositions for promoting intestinal angiogenesis and nutrient absorption and enteral feeding tolerance and / or preventing and / or treating intestinal inflammation such as necrotizing enterocolitis, and / or intestinal injury and / or recovery after surgery. The composition is for mammals, preferably humans, more preferably infants. Background of the invention [0002] Accelerated vascularization in the intestinal mucosa occurs during neonatal infancy, especially premature infants. Neovascularization and vascular repair are also critical during healing after intestinal injury and / or surgery. Neovascularization and vascular repair occur via angiogenesis. [0003] Infants, especially preterm and LBW infants, can experience immature intestinal vascularization and thus reduced blood flow to the intestinal mucosa (Reber KM, Nankervis CA, Nowicki PT. Newborn intestinal circulation. Physiology and pathophysiology. Clin Perinat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23D9/00A23L1/052A23L1/30A61K31/00A23L29/206A23L33/00
CPCA61K35/747A61K31/202A61K31/702A23L1/3014A61K31/7004A23L1/308A23L1/296A23L1/3006A61K31/7016A61K2035/115A23L1/293A61K35/745A23L33/30A23L33/40A23L33/115A23L33/135A23L33/21A61P1/00A61P1/14A61K2300/00A61K35/741A23D9/00
Inventor C·加西亚-罗德纳斯N·斯普伦格
Owner NESTEC SA
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