Phospholipid complex containing dracocephalum moldavica total flavonoids, self-emulsifying agent prepared from same and preparation method of phospholipid complex containing dracocephalum moldavica total flavonoids

Abstract

The invention relates to the technical field of dracocephalum moldavica extracts and provides a phospholipid complex containing dracocephalum moldavica total flavonoids, a self-emulsifying agent prepared from the same and a preparation method of the phospholipid complex containing dracocephalum moldavica total flavonoids. The preparation method of the phospholipid complex containing dracocephalum moldavica total flavonoids comprises the following steps: dissolving a proper amount of phospholipid in organic solvents A with low boiling points, then adding dracocephalum moldavica total flavonoids, and mixing the materials uniformly, thus obtaining mixed liquor, wherein the mass ratio of phospholipid to dracocephalum moldavica total flavonoids is (1:1)-( 1:4); 1ml of organic solves are added to 1-15mg of dracocephalum moldavica total flavonoids; the mixed liquor is put in a water bath to be stirred at constant temperature for 0.5-2 hours. The self-emulsifying agent prepared from the phospholipid complex containing dracocephalum moldavica total flavonoids greatly improves the solubility of the dracocephalum moldavica total flavonoids in gastrointestinal tracts, thus improving the bioavailability of the dracocephalum moldavica total flavonoids and then better giving play to the medicine efficacy, and the self-emulsifying agent has stable physical and chemical properties.

Description

technical field [0001] The invention relates to the technical field of sweet blue orchid extract, and relates to a sweet green blue total flavonoid phospholipid complex, a sweet green blue total flavonoid phospholipid complex self-emulsifier and a preparation method thereof. Background technique [0002] , Research progress and background introduction of phospholipid complexes [0003] Phospholipid complexes were discovered by the Italian scholar Bombardelli when he was studying liposomes. Most of the drugs involved in the early research on phospholipid complexes were flavonoids or polyphenols containing phenolic hydroxyl groups. Later studies confirmed that, in addition to phenolic hydroxyl groups, Polar groups such as some alcohol hydroxyl groups, amide groups or carbonyl groups may form complexes with the hydrophilic ends of phospholipids or other lipid materials (such as cholesterol, sodium cholate, etc.) through intermolecular hydrogen bonds or van der Waals interaction...

AI Technical Summary

Problems solved by technology

[0013] The present invention provides a kind of total flavonoid phospholipid complex of sweet green orchid, self-emulsifier and preparation method thereof of total flavonoid phospholipid complex of sweet green orchid, which overcomes the above-mentioned problems There are technical deficiencies, which can effectively solve the problem that the existing sweet orchid extract has poor solubility and is not easily absorbed in the gastrointestinal tract, which leads to low bioavailability and cannot fully exert its medicinal effect