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New use of acarbose

A new-purpose technology of acarbose, applied in the field of medicinal chemistry, can solve problems such as concealment, poor curative effect, seriousness, etc., achieve obvious therapeutic and/or preventive effects, improve blood vessel and nerve function, and alleviate the effects of diabetes manifestations

Inactive Publication Date: 2014-06-25
JIANGSU WANBANG BIOPHARMLS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical manifestations of diabetic patients with coronary heart disease are more serious and hidden than those of non-diabetic coronary heart disease patients, and because the pathological changes are more extensive and serious than those of non-diabetic coronary heart disease patients, the curative effect of conventional drug treatment is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Therapeutic effect of acarbose on diabetic patients with coronary heart disease.

[0014] 1. Experimental objects and grouping: 60 patients with type Ⅱ diabetes complicated with coronary heart disease and angina pectoris were randomly divided into two groups, 30 cases in the control group, 14 males and 16 females; aged 50-70 years, average (55±4.2) age; the duration of diabetes is 2 to 13 years, and the duration of coronary heart disease and angina pectoris is 3 months to 6 years. The treatment group included 30 cases, 13 males and 17 females; aged 50 to 68 years, with an average (54±5.0) years; the duration of diabetes was 3 to 14 years, and the duration of coronary heart disease and angina pectoris was 3 months to 6 years. Both groups had different degrees of paroxysmal retrosternal compression suffocation, precordial pain, palpitation and other symptoms. There was no significant difference between the two groups in terms of gender, age and condition after statistica...

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Abstract

The invention provides a use of acarbose in the preparation of medicines for treating and / or preventing diabetes combined with coronary heart disease. Clinical test researches in the invention show that acarbose has a better curative effect on diabetic patients with coronary heart disease than on non-diabetic patients with coronary heart disease, and acarbose can effectively alleviate the diabetic symptoms of patients, and can also improve the vascular nerve function, so acarbose is beneficial to recover the overall conditions of the patients, and has a significant treatment and / or prevention effect on the diabetes combined with coronary heart disease.

Description

technical field [0001] The present invention relates to the field of medicinal chemistry. Specifically, the present invention relates to a new medical application of acarbose, that is, the application of acarbose in the preparation of medicines for treating and / or preventing diabetes complicated with coronary heart disease. Background technique [0002] Acarbose is a new oral hypoglycemic agent. Competitively inhibits glucoside hydrolases in the gut. Reduce the decomposition of polysaccharides and sucrose into glucose, so that the absorption of sugar is correspondingly slowed down, so it can have the effect of lowering blood sugar after meals. Generally used alone, or in combination with other oral hypoglycemic agents, or insulin. Combined with meals to treat insulin-dependent or non-dependent diabetes. [0003] Diabetes is a common chronic disease that seriously endangers human health. Currently, there are nearly 200 million diabetics in the world, and nearly half live...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61P3/10A61P9/10
Inventor 高雪芹乔德水
Owner JIANGSU WANBANG BIOPHARMLS
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