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Application of 5,6,7-trihydroxy-8-methoxyflavone in the preparation of anti-hypoxic drugs

A technology of methoxyflavones and anti-hypoxic drugs, which is applied in the field of medicine and can solve unseen problems

Active Publication Date: 2017-04-19
中国人民解放军联勤保障部队第九四〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the biological activity of 5,6,7-trihydroxy-8-methoxyflavone

Method used

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  • Application of 5,6,7-trihydroxy-8-methoxyflavone in the preparation of anti-hypoxic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] tablet:

[0059] 5,6,7-trihydroxy-8-methoxyflavone (purity greater than 95%) 50.0g,

[0060] Starch (Shaanxi Aoke Pharmaceutical Excipients Co., Ltd.) 130.0g,

[0061] Microcrystalline cellulose (MCC, Shaanxi Aoke Pharmaceutical Excipients Co., Ltd.) 10.0g,

[0062] Methylcellulose (Anhui Shanhe Pharmaceutical Excipients Co., Ltd.) 6.0g,

[0063] Magnesium stearate (Shaanxi Aoke Pharmaceutical Excipients Co., Ltd.) 4.0g,

[0064] 200.0g total.

[0065] Prepared according to the conventional tablet method, a total of 1000 tablets were made, and each tablet contained 50 mg of 5,6,7-trihydroxy-8-methoxyflavone.

Embodiment 2

[0067] Capsules:

[0068] 5,6,7-trihydroxy-8-methoxyflavone (purity greater than 95%) 50.0g,

[0069] Starch 135.0g,

[0070] Methylcellulose 5.0g,

[0071] Magnesium Stearate 10.0g,

[0072] 200.0g total.

[0073] Prepared according to the conventional method of capsules, 1000 capsules are prepared in total, and each capsule contains 50 mg of 5,6,7-trihydroxy-8-methoxyflavone.

Embodiment 3

[0075] Dispersible tablets:

[0076] 5,6,7-trihydroxy-8-methoxyflavone (purity greater than 95%) 50.0g,

[0077] Microcrystalline cellulose (MCC) 130.0g,

[0078] Croscarmellose sodium (cCMC-Na) 20.0g,

[0079] 200.0g total.

[0080] Prepared according to the conventional method for dispersible tablets, a total of 1000 tablets were made, each containing 50 mg of 5,6,7-trihydroxy-8-methoxyflavone.

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Abstract

The invention discloses an application of 5,6,7,8- trihydroxy-8-methoxyflavone in preparing an anti-hypoxic drug which is the drug for preventing and treating hypoxic injury diseases; the hypoxic injury diseases are high-altitude low-pressure oxygen deficit-caused acute high altitude diseases, cerebral ischemia hypoxic diseases or myocardial ischemia hypoxic diseases. The application has beneficial effects as follows: an experiment proves that the 5,6,7,8- trihydroxy-8-methoxyflavone has a remarkable anti-hypoxic effect, and an effect tending to be better than that of acetazolamide; the anti-hypoxic drug prepared by applying the 5,6,7,8- trihydroxy-8-methoxyflavone as an active ingredient can be used for preventing and treating hypoxic injuries or treating various hypoxic pathological states caused by oxygen content drop in external environment, also can be used for preventing or treating hypoxic pathological states of heart, brain, respiratory system, and the like as external normal oxygen cannot sufficiently get to a body due to diseases, and the like, and further can be used for preventing or treating the pathological state that relative oxygen supply is insufficient as oxygen consumption needed for activities of the body exceeds physiological mobilization ability.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of 5,6,7-trihydroxy-8-methoxyflavone in the preparation of anti-hypoxic drugs. Background technique [0002] With the change of people's lifestyle and the accelerated pace of life, hypoxia has become a fairly common pathological process. The main causes of hypoxia are: low oxygen content or partial pressure in the atmosphere in the environment, respiratory, blood Circulation and other system diseases lead to oxygen supply and oxygen utilization disorders and the body's oxygen consumption is greater than the supply. The low-pressure and hypoxic environment in plateau areas often makes people who are new to the plateau prone to acute altitude sickness such as headache, palpitations, chest tightness, shortness of breath, fatigue, sleep disturbance, nausea, and vomiting. In severe cases, high-altitude pulmonary edema and high-altitude cerebral edema may also occur. Long-term ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P39/00A61P9/10
Inventor 景临林马慧萍樊鹏程蒙萍王宁贾正平
Owner 中国人民解放军联勤保障部队第九四〇医院
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