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Application of chrysin in the preparation of anti-hypoxic drugs

A technology of chrysin and drug, applied in the field of medicine, can solve the problems of lack of anti-hypoxic injury protective drugs, no anti-hypoxia activity, etc.

Active Publication Date: 2016-01-06
中国人民解放军联勤保障部队第九四〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the prevention effect or economic cost and other reasons, there is a shortage of anti-hypoxic injury protection drugs suitable for popularization and application.
However, there is no report on anti-hypoxic activity research

Method used

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  • Application of chrysin in the preparation of anti-hypoxic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] tablet:

[0070] Chrysin (purity greater than 95%, Shaanxi Ciyuan Biotechnology Co., Ltd.) 50.0g,

[0071] Starch (filler, Shaanxi Aoke Pharmaceutical Excipients Co., Ltd.) 130.0g,

[0072] Microcrystalline cellulose (MCC, disintegrant, Shaanxi Aoke Pharmaceutical Excipients Co., Ltd.) 10.0g,

[0073] Methylcellulose (binder, Anhui Shanhe Pharmaceutical Excipients Co., Ltd.) 6.0g,

[0074] Magnesium stearate (lubricant, Shaanxi Aoke Pharmaceutical Excipients Co., Ltd.) 4.0g,

[0075] A total of 200.0g.

[0076] Prepared according to the conventional tablet method, and made 1000 tablets in total, each containing 50 mg of chrysin.

Embodiment 2

[0078] Capsules:

[0079] Chrysin (purity greater than 95%) 50.0g,

[0080] Starch (filler) 135.0g,

[0081] Methylcellulose (binder) 5.0g,

[0082] Magnesium stearate (lubricant) 10.0g,

[0083] A total of 200.0g.

[0084] Prepare according to the conventional method of capsules, and make 1000 capsules altogether, each capsule contains 50 mg of chrysin.

Embodiment 3

[0086] Dispersible tablets:

[0087] Chrysin (purity greater than 95%) 50.0g,

[0088] Microcrystalline Cellulose 130.0g,

[0089] Croscarmellose sodium (cCMC-Na, Anhui Shanhe Pharmaceutical Excipients Co., Ltd.) 20.0g,

[0090] A total of 200.0g.

[0091] Prepared according to the conventional method for dispersible tablets, a total of 1000 tablets were made, each containing 50 mg of chrysin.

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PUM

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Abstract

The invention discloses the application of chrysin in the preparation of anti-hypoxic drugs. The anti-hypoxic drugs are drugs for preventing and treating hypoxic damage diseases, and the hypoxic damage diseases are acute high altitude sickness, cerebral Ischemic-hypoxic disease or myocardial ischemic-hypoxic disease. The beneficial effects of the present invention are as follows: it is proved by experiments that chrysin has a significant anti-hypoxic effect, and the effect tends to be better than that of acetazolamide. Injury or treatment of various hypoxic pathological states caused by the reduction of oxygen content in the external environment. It can also be used to prevent or treat diseases that cause normal oxygen in the outside world to not fully reach the body, resulting in hypoxic pathology such as the heart, brain and respiratory system. It can also be used to prevent or treat the pathological state of relative oxygen supply deficiency caused by the oxygen consumption required by body activities exceeding the physiological mobilization capacity.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of chrysin in the preparation of anti-hypoxic drugs. Background technique [0002] The pathological process that causes changes in body metabolism, function, and morphological structure due to the reduction of tissue oxygen supply or the obstruction of oxygen utilization is called hypoxia. With the change of people's lifestyle and the accelerated pace of life, hypoxia has become a fairly common pathological process. Oxygen supply and oxygen utilization disorders occur in circulatory and other system diseases. Third, the oxygen consumption required by the body is greater than the supply. Plateau hypoxia belongs to low-pressure hypoxia, which often makes people who first arrive at the plateau prone to acute altitude sickness such as headache, palpitations, chest tightness, shortness of breath, fatigue, sleep disturbance, nausea, and vomiting. Fatal diseases such as cerebra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P39/00
Inventor 马慧萍景临林樊鹏程高荣敏蒋炜贾正平
Owner 中国人民解放军联勤保障部队第九四〇医院
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