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Hydrochloric acid methadone sustained release tablet

A technology of methadone hydrochloride and sustained-release tablets, which is applied in the direction of medical preparations of non-active ingredients, pill delivery, organic active ingredients, etc., can solve the problems of unreported preparation methods of prescription components, and achieve easy scale-up production and good stability The effect of sex and simple process

Inactive Publication Date: 2014-06-25
王媛媛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report about dispersible tablets made from methadone hydrochloride in China, and only the United States has a trade name (Dispersible Tablets CII, USP, 2007) report, but did not report prescription components (dosage ratio) and its preparation method

Method used

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  • Hydrochloric acid methadone sustained release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 prescription:

[0038] Methadone Hydrochloride 5g

[0039] Hypromellose K4M 40g

[0040] Hypromellose E50 20g

[0041] Lactose 120g

[0042] Povidone K30 8g

[0043] Magnesium Stearate 2g

[0044] Made in 1000 pieces.

[0045] Preparation Process:

[0046] (1) Methadone hydrochloride, hypromellose (K4M), hypromellose (E50) and lactose were sieved and set aside.

[0047] (2) prepare povidone K30 ethanol solution as adhesive, and set aside.

[0048](3) Take prescription amount of methadone hydrochloride, hypromellose (K4M), hypromellose (E50), lactose and mix, add binder to granulate, add prescription amount of magnesium stearate after drying and mix evenly.

[0049] (4) Tablets.

[0050] (5) Coating: Take the prescribed amount of colored film coating agent to prepare a coating solution (oxygen barrier, light protection). The plain tablets are placed in a coating pan, sprayed with a film coat, and dried.

Embodiment 2

[0051] Embodiment 2 prescription:

[0052] Methadone Hydrochloride 5g

[0053] Hypromellose K4M 50g

[0054] Hypromellose E50 25g

[0055] Lactose 100g

[0056] Povidone K30 8g

[0057] Magnesium Stearate 2g

[0058] Made in 1000 pieces.

[0059] Preparation Process:

[0060] (1) Methadone hydrochloride, hypromellose (K4M), hypromellose (E50) and lactose were sieved and set aside.

[0061] (2) prepare povidone K30 ethanol solution as adhesive, and set aside.

[0062] (3) Take prescription amount of methadone hydrochloride, hypromellose (K4M), hypromellose (E50), lactose and mix, add binder to granulate, add prescription amount of magnesium stearate after drying and mix evenly.

[0063] 4) Tablets.

[0064] (5) Coating: Take the prescribed amount of colored film coating agent to prepare a coating solution (oxygen barrier, light protection). The plain tablets are placed in a coating pan, sprayed with a film coat, and dried.

Embodiment 3

[0065] Embodiment 3 prescription:

[0066] Methadone Hydrochloride 5g

[0067] Hypromellose K4M 60g

[0068] Hypromellose E50 24g

[0069] Lactose 60g

[0070] Povidone K30 8g

[0071] Magnesium Stearate 2g

[0072] Made in 1000 pieces.

[0073] Preparation Process:

[0074] (1) Methadone hydrochloride, hypromellose (K4M), hypromellose (E50) and lactose were sieved and set aside.

[0075] (2) prepare povidone K30 ethanol solution as adhesive, and set aside.

[0076] (3) Take prescription amount of methadone hydrochloride, hypromellose (K4M), hypromellose (E50), lactose and mix, add binder to granulate, add prescription amount of magnesium stearate after drying and mix evenly.

[0077] 4) Tablets.

[0078] 5) Coating: Take the prescribed amount of colored film coating agent to prepare a coating solution (oxygen barrier, light protection). The plain tablets are placed in a coating pan, sprayed with a film coat, and dried.

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Abstract

The invention discloses a hydrochloric acid methadone sustained release tablet which contains hydrochloric acid methadone, high-viscosity hydroxypropyl methylcellulose, low-viscosity hydroxypropyl methylcellulose, a water-soluble filling agent and other medical auxiliary materials. The invention further discloses a preparation method of the hydrochloric acid methadone sustained release tablet. The hydrochloric acid methadone can be used as an anesthesia medicine used in an operating room, and is used for relieving pain.

Description

field of invention [0001] The invention relates to the field of chemical pharmacy, in particular to anesthesia medicine for operation and a pharmaceutical preparation for relieving pain of patients, that is, a methadone hydrochloride sustained-release tablet. Background of the invention [0002] Methadone hydrochloride is an opioid receptor agonist that mainly acts on receptors. Its pharmacological action is similar to that of morphine, and its analgesic efficacy and duration are similar to that of morphine. It can be used for anesthesia in the operating room, or to relieve pain in patients. Methadone hydrochloride can also produce respiratory depression, antitussive, cooling, and miotic effects. The sedative effect is weak, but repeated administration can still cause obvious sedative effects. It is characterized in that it is effective when taken orally, has a long period of action in suppressing the withdrawal symptoms of morphine addicts, and is still effective after rep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/137A61K47/38A61P25/04A61P23/00
Inventor 王媛媛
Owner 王媛媛
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