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Method for preparing liquorice active substances

A technology of active substance and licorice root, applied in the field of preparation of licorice active substance, can solve the problems of low product purity, complicated and time-consuming steps and the like

Inactive Publication Date: 2014-06-18
内蒙古普凡生生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent (CN101766680A) discloses a comprehensive extraction method of licorice. After three extractions with different solvents, crude glycyrrhizic acid, licorice polysaccharide and licorice flavonoids are obtained. This step is complicated and time-consuming and the product has low purity.

Method used

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  • Method for preparing liquorice active substances
  • Method for preparing liquorice active substances
  • Method for preparing liquorice active substances

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preparation example Construction

[0087] A preparation method of licorice active substance, the steps comprising:

[0088] Step 1: pretreatment of raw materials;

[0089] Sieve the licorice to remove various impurities, then wash with water, remove dust, dry, and crush through a 60-mesh sieve.

[0090] Step 2: hot water extraction treatment;

[0091] Glycyrrhiza licorice was extracted with hot water to obtain extract I. The extraction temperature is 75-95°C, the ratio of solid to liquid is 1:5-1:15 (mass volume ratio w / v), the number of extractions is 1-3 times, and each extraction time is 3 hours. The extract I was filtered through a 200-mesh filter cloth to obtain the crude filtrate I, and the filter residue was used for later use.

[0092] Step 3: Ultrasonic-assisted extraction treatment of licorice residue;

[0093] The filter residue obtained in step 2 is used for ultrasonic assisted leaching to obtain extract II. The ultrasonic power is 300-500W, the extraction temperature is 60-80°C, the ratio of s...

Embodiment 1

[0121] A preparation method of licorice active substance, the production steps are:

[0122] (1) Pretreatment of raw materials: Screen licorice to remove various impurities, then wash with water, remove dust, dry, and grind through a 60-mesh sieve.

[0123] (2) Hot water extraction treatment: hot water extraction treatment of licorice to obtain extract I. The extraction temperature is 75°C, the solid-to-liquid ratio is 1:5 (w / v), the extraction frequency is 1 time, and the extraction time is 3 hours. The extract I was filtered through a 200-mesh filter cloth to obtain the crude filtrate I, and the filter residue was used for later use.

[0124] (3) Ultrasonic-assisted extraction treatment of licorice residue: the filter residue obtained in step (2) is used for ultrasonic-assisted extraction to obtain extract solution II. Ultrasonic-assisted extraction conditions: power 300W, extraction temperature 60°C, feed liquid The ratio is 1:10 (w / v), the number of leaching is 1 time, a...

Embodiment 2

[0135] A preparation method of licorice active substance, the production steps are:

[0136] (1) Pretreatment of raw materials: Screen licorice to remove various impurities, then wash with water, remove dust, dry, and grind through a 60-mesh sieve.

[0137] (2) Hot water extraction treatment: hot water extraction treatment of licorice to obtain extract I. The extraction temperature is 85°C, the ratio of solid to liquid is 1:15 (w / v), the number of extractions is 3 times, and each extraction time is 3 hours. The extract I was filtered through a 200-mesh filter cloth to obtain the crude filtrate I, and the filter residue was used for later use.

[0138] (3) Ultrasonic-assisted extraction treatment of licorice residue: use the filter residue obtained in step (2) for ultrasonic-assisted extraction to obtain extract solution II. Ultrasonic-assisted extraction conditions: power 500W, extraction temperature 70°C, material The liquid ratio is 1:10 (w / v), the number of leaching times...

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Abstract

The invention discloses a method for preparing liquorice active substances. The method comprises the following steps: pretreatment and hot water extraction treatment of raw materials and ultrasonic auxiliary extraction treatment, alcohol precipitation treatment, purification treatment, acid precipitation treatment, redissolution treatment, ammoniated treatment, acidification treatment, crystallization and purification of liquorice residues. The method can be used for fully utilizing liquorice source, and achieving the separation of different effective components during extraction to avoid the loss of other several active substances during single extraction; the production cost is low, the operation is simple, the production efficiency is high, and no environment pollution is produced; by utilizing the method, continuous production is achieved, and the products obtained according to the method have high quality; the method is easily popularized and utilized and provides a new approach for comprehensive utilization of liquorice; by utilizing the method, the comprehensive utilization value of liquorice is improved.

Description

technical field [0001] The invention relates to a comprehensive utilization technology of Chinese herbal medicines, in particular to a preparation method of licorice active substances. Background technique [0002] Licorice (Glycyrrhizauralensis), also known as sweet grass root, red licorice, Guo Lao, sweet grass, sweet root seed, etc., is one of the traditional Chinese herbal medicines commonly used in my country. Licorice is flat and sweet in nature, and has the functions of invigorating the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving acute pain and reconciling various medicines, and has a very wide clinical application value. In my country, licorice is the most used herb among more than 2,000 kinds of herbs. At the same time, licorice is the best natural sweetener ever discovered. Licorice is widely distributed between 30-55° north latitude, and the arid and semi-arid areas around 40° north latitude are ...

Claims

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Application Information

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IPC IPC(8): A61K36/484C08B37/00C07J63/00C07H15/256C07H1/08
Inventor 高彦祥樊蕊李铁军
Owner 内蒙古普凡生生物科技有限公司
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