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Extraction and purification technology for aconitine in monkshood

A technology of aconitine and Aconitine, which is applied in the field of extracting and refining active ingredients in traditional Chinese medicine, can solve the problems of inability to effectively extract and purify aconitine in Aconitine, improve extraction rate and purification effect, efficiently extract and purify, Process smooth effect

Inactive Publication Date: 2014-06-04
杨超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the problem that aconitine from Aconitum aconitum cannot be effectively extracted and purified in the above-mentioned prior art, and provides an extraction and purification process for aconitine from Aconitum aconitum, which can quickly and effectively extract and purify aconitine from Aconitum aconitum alkali

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A process for extracting and purifying aconitine from Aconitum aconitum, comprising the following process steps:

[0026] A. Ethanol reflux extraction

[0027] Dried and crushed Aconitum aconitum, added ethanol to reflux extraction twice, each time for 1.5 hours, filtered, combined the filtrates, and concentrated into Aconitum aconitum concentrated paste;

[0028] B. Static adsorption of macroporous adsorption resin

[0029] Dissolve the Aconitum concentrated paste obtained in step A in acetone, stir evenly, add AB-8 macroporous adsorption resin to the acetone solution of Aconitum concentrated paste, soak for 55 hours, elute the resin with distilled water, and combine the washing liquid and the filtrate Obtain static adsorption liquid;

[0030] C. Dynamic adsorption of macroporous adsorption resin

[0031] Adjust the pH of the static adsorption solution to 9, put it on the AB-8 macroporous adsorption resin column, and then elute with distilled water and 70% ethanol i...

Embodiment 2

[0033] A process for extracting and purifying aconitine from Aconitum aconitum, comprising the following process steps:

[0034] A. Ethanol reflux extraction

[0035] Dried and crushed Aconitum aconitum, adding ethanol to reflux extraction for 3 times, each time for 3.5 hours, filtering, combining the filtrates, and concentrating into Aconitum aconitum concentrated paste;

[0036] B. Static adsorption of macroporous adsorption resin

[0037] Dissolve the Aconitum concentrated paste obtained in step A in acetone, stir evenly, add AB-8 macroporous adsorption resin to the acetone solution of Aconitum concentrated paste, soak for 60 hours, elute the resin with distilled water, and combine the washing liquid and the filtrate Obtain static adsorption liquid;

[0038] C. Dynamic adsorption of macroporous adsorption resin

[0039] Adjust the pH of the static adsorption solution to 11, put it on the AB-8 macroporous adsorption resin column, and elute with distilled water and 70% eth...

Embodiment 3

[0041] A process for extracting and purifying aconitine from Aconitum aconitum, comprising the following process steps:

[0042] A. Ethanol reflux extraction

[0043] Dried and crushed Aconitum aconitum, adding ethanol to reflux extraction for 3 times, each time for 2 hours, filtering, combining the filtrates, and concentrating into Aconitum aconitum concentrated paste;

[0044] B. Static adsorption of macroporous adsorption resin

[0045] Dissolve the Aconitum concentrated paste obtained in step A in acetone, stir evenly, add AB-8 macroporous adsorption resin to the acetone solution of Aconitum concentrated paste, soak for 58 hours, elute the resin with distilled water, and combine the washing liquid and the filtrate Obtain static adsorption liquid;

[0046] C. Dynamic adsorption of macroporous adsorption resin

[0047] Adjust the pH of the static adsorption solution to 10, put it on the AB-8 macroporous adsorption resin column, and then elute with distilled water and 70% ...

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Abstract

The invention relates to an extraction and purification technology for aconitine in monkshood, and belongs to the technical fields of extraction and purification of effective components in traditional Chinese medicines. The aconitine in the monkshood is extracted and purified by adopting a mode of combining ethanol reflux extraction, static adsorption purification of macroporous adsorption resin and dynamic adsorption and purification. Thus, the problem that the aconitine in the monkshood cannot be quickly and effectively extracted by the prior art is solved, and the aconitine in gastrodia elata can be quickly and efficiently extracted and purified.

Description

technical field [0001] The invention relates to a process for extracting and refining active ingredients in traditional Chinese medicine, more specifically, the invention relates to a process for extracting and purifying aconitine from Aconitum aconitum, belonging to the technical field of extracting and refining active ingredients in traditional Chinese medicine. Background technique [0002] Chuanwu, Aconite Root, also known as goose flower, iron flower, five poisons. Born in mountain grass slopes or shrubs. Cultivated in flat, fertile sandy soil, mainly in Sichuan. Distributed in the middle and lower reaches of the Yangtze River, north to the Qinling Mountains and eastern Shandong, and south to northern Guangxi. [0003] Aconitine is the main active ingredient in Aconitum aconitum and has a wide range of uses. In the prior art, methods such as solvent extraction or ion exchange resin are mostly used for extraction, and the extraction rate is very low. [0004] The Stat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D221/22
CPCC07D221/22
Inventor 杨超
Owner 杨超
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