Application of tetrahydroisoquinoline compound for preparing drug killing animal mites

Abstract

The invention discloses application of a tetrahydroisoquinoline compound for preparing a drug killing animal mites. The compound has the molecular structure feature shown in the specification, wherein R is ortho-, meta- or para-alkyl, alkoxy, halogen, hydroxyl, nitro, trifluoromethyl, cyano group and the like. The compound has good activity in killing multiple animal mites like psoroptes communis cuniculi, which is superior to that of the clinical mite killing drug ivermectin, and has chemical stability and good compatibility with physiological environment.

Description

technical field [0001] The invention relates to the application of a class of tetrahydroisoquinoline compounds as animal acaricides. Background technique [0002] Livestock and poultry acariasis is a kind of ectoparasitic disease that is ubiquitous and seriously endangers the health of animals. It is characterized by contact infection, severe itching and severe skin inflammation. It can cause severe stress reactions in animals and affect animal feeding and sleep. , feed efficiency and animal weight gain, severe cases can cause animal death. The occurrence of animal mites is very common and quite stubborn. Pigs, sheep, cattle, chickens, rabbits, dogs, foxes, mice, etc. are all infected with mites and the incidence is very high. Therefore, the disease seriously affects the production performance of animals and the quality of livestock products. In addition, mites also play an intermediary role in the spread of bacterial and viral diseases. [0003] For a long time, the cont...

AI Technical Summary

Problems solved by technology

But at present, abamectin class acaricides are facing serious problems in three aspects: one, like all chemical drugs, along with the long-term use of abamectin class drugs, more and more mites have produced With the increasingly serious drug resistance, the recurrence and superinfection of acariasis are becoming more and more frequent; secondly, the adverse environmental and ecological impacts caused by abamectins due to their broad-spectrum, high-efficiency, and stable characteristics have aroused strong concern. Residual drugs in animal excrement can seriously affect the decomposition process of many normal microorganisms and protozoa; third, abamectin drugs can only drive and kill insects, but are ineffective against eggs. Only repeated medication can improve the rate of deworming rate, prevent the recurrence of mite

However, there is no report about the application of these compounds as acaricides

Images