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Gynecologic gel with antibacterial restoration activity and preparation method thereof

A gel, gynecological technology, used in medical science, bandages, absorbent pads, etc., can solve the problem of not including antibacterial repair

Inactive Publication Date: 2014-06-04
GUIZHOU YANGSHENG MEDICAL INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In these documents, some innovations have been made in the technology of bioactive glass for external wound repair, but in these patents and their applications, some need to be combined with antibiotics or anti-inflammatory drugs, and some need to be freeze-dried. Sponge requires a cross-linking agent, and these patents and their applications all focus on the forging process of bioactive glass, but none of them contain polyaminopolysaccharide polypeptide complex iodine, an active ingredient with dual functions of antibacterial repair
[0007] At present, there is no literature report on polyaminoglycan polypeptide complexed iodine complexed bioactive glass gel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Prepare materials according to the following formula: sodium alginate 5g, bioactive glass 2g, gelatin 20g, glycerin 30mL, 2% chitosan iodine solution 100mL. Under the condition of 30℃~40℃ water bath, add alginate into chitosan iodine solution while stirring, and continue stirring for 15~45 min; then, under the condition of 30℃~40℃ water bath, stir while stirring Add active glass powder into the solution and keep stirring to prevent delamination; at the same time, according to the softness and elasticity requirements of the target gel, mix and dissolve the pre-weighed gelatin and glycerin, and mix and dissolve them together at 121°C and 0.1MPa. Under high temperature and high pressure for 10-40 minutes, then stir for 5-15 minutes in a water bath at 45°C to 60°C to form a glycerin gelatin viscous body; finally, in a water bath at 45°C to 60°C, mix the glycerin gelatin with stirring The viscous body is introduced into the biologically active colloidal solution, ...

Embodiment 2

[0025] Example 2 Prepare materials according to the following formula: Potassium alginate 0.5g, bioactive glass 0.1g, gelatin 30g, glycerin 60mL, 8% chitosan iodine solution 100mL. The preparation method is the same as in Example 1, and the polyaminopolysaccharide polypeptide complexed iodine complex bioactive glass gel is obtained.

Embodiment 3

[0026] Example 3 Weigh according to the following formula: calcium alginate 15g, bioactive glass 5g, gelatin 2g, glycerin 4mL, 1% chitosan iodine solution 100mL. The preparation method is the same as in Example 1, and the polyaminopolysaccharide polypeptide complexed iodine complex bioactive glass gel is obtained.

[0027] The polyaminopolysaccharide polypeptide complexed iodine complex bioactive glass gel is the target product of the present invention—the gynecological gel with antibacterial and repairing activity.

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Abstract

The invention discloses gynecologic gel with antibacterial restoration activity and a preparation method thereof. The gynecologic gel is polyamino polysaccharide polypeptide complex iodine compound bioactive glass gel which is formed by taking a chitosan iodine solution and a bioactive glass as main active components, carbomer and sodium alginate as adhesives and gelatin as a shaping agent and has an antibacterial restoration function, wherein the chitosan iodine can not only kill pathogen by providing free iodine, but also promote the healing of a wound tissue part, the bioactive glass is permeated through the soakage of a human body fluid, and the surface activity of the bioactive glass can promote the generation of a growth factor positioned on the wound tissue part and promote cell proliferation after contacting with a wound tissue. The gynecologic gel disclosed by the invention can not only kill the pathogen by providing the free iodine, but also promote the healing of the wound tissue part, has good biocompatibility and is plastic gel which can be used for treating gynecological inflammation and has antibacterial restoration activity. The preparation method disclosed by the invention is simple, convenient and suitable for industrialized production.

Description

technical field [0001] The present invention relates to medical preparations, more specifically, to gel medical dressings, especially gel dressings for gynecology. technical background [0002] Gynecological inflammation, including vaginitis, cervicitis, etc., is an inflammation caused by the invasion of pathogenic bacteria due to external injury or infection. Gynecological inflammation is a common disease that plagues the majority of female patients. The treatment of gynecological inflammation is mainly to remove or kill pathogens through local administration, restore the normal microenvironment, and repair damaged tissues, so as to achieve a healing effect. [0003] Chitosan iodine, the complex of chitosan and iodine, has natural antibacterial activity, and has a wide antibacterial spectrum, and has obvious inhibitory effect on Gram-positive bacteria, Gram-negative bacteria and Candida albicans. Bacteria effect, existing a large number of literature reports that chitos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/44A61L15/42
Inventor 陈阶黄昌平聂开品郑茂鑫
Owner GUIZHOU YANGSHENG MEDICAL INSTR
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