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Pain alleviating and collateral activating tincture composition and preparation method thereof

An analgesic and activating collaterals tincture and composition technology, which is applied in the field of analgesic and activating collaterals tincture composition and its preparation with high solid content, and can solve the problem of quality influence of analgesic and activating collaterals tincture, difficulty in controlling total solid content, total solids of analgesic and activating collaterals tincture Low content and other problems, to achieve the effect of increasing the content

Inactive Publication Date: 2014-05-28
SHANGHAI JINGFENG PHARMA
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0012] But because the total solid content in the analgesic and active collateral tincture prepared by the above method is always low, usually only about 1.5%, it is not only difficult to control the total solid content in production, but also if the total solid content is low, it will affect the quality of the analgesic active collateral tincture. have a very large impact

Method used

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  • Pain alleviating and collateral activating tincture composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] a Passepartout 6.25g, Chinese prickly ash 6.25g, hematoxylin 4.69g, Puhuang 4.69g, camphor wood 4.69g, red peony 3.12g, safflower 3.12g;

[0034] (2) Put 625ml of 95% ethanol in a jar, add 16 herbs (except camphor) of analgesic and active tincture;

[0035] (3) It was then placed in a disintegrator adjusted to 40°C for 48 hours, during which time it was stirred for 5 minutes every 4 hours;

[0036] (4) After filtering the medicinal liquid with a 200-mesh sieve, pour the medicinal liquid into the dissolver, add 500 ml of purified water to the medicinal residues, stir for 5 minutes and filter, collect 1000 ml of medicinal liquid, and the ethanol concentration is 52-60%;

[0037] (5) Add 50ml of camphor solution to the filtrate (dissolve 6.25g of camphor in 50ml of 60% ethanol solution, stir with a glass rod until there are no large camphor particles) and mix for 10 minutes;

[0038] (6) Put it into an analgesic active tincture bottle and send it for inspection.

Embodiment 1

[0040] a Passepartout 6.25g, Chinese prickly ash 6.25g, hematoxylin 4.69g, Puhuang 4.69g, camphor wood 4.69g, red peony 3.12g, safflower 3.12g;

[0041] (2) Put 1125ml of 60% ethanol in a jar, add 16 herbs (except camphor) of analgesic and active tincture;

[0042] (3) It was then placed in a disintegrator adjusted to 40°C for 48 hours, during which time it was stirred for 5 minutes every 4 hours;

[0043] (4) After filtering the medicinal liquid with a 200-mesh screen, the filtrate is placed in a container, and 1000 ml of medicinal liquid is collected, and the ethanol concentration is 52-60%;

[0044] (5) Add 50ml of camphor solution to the filtrate (dissolve 6.25g of camphor in 50ml of 60% ethanol solution, stir with a glass rod until there are no large camphor particles) and mix for 10 minutes;

[0045] (6) Put it into an analgesic active tincture bottle and send it for inspection.

Embodiment 2

[0047] a Passepartout 6.25g, Chinese prickly ash 6.25g, hematoxylin 4.69g, Puhuang 4.69g, camphor wood 4.69g, red peony 3.12g, safflower 3.12g;

[0048] (2)) Put 1125ml of 60% ethanol in a jar, add 16 herbs (except camphor) of analgesic and active tincture;

[0049] (3) Then placed in a disintegrator adjusted to 20°C for 48 hours, during which time was stirred for 5 minutes every 4 hours;

[0050] (4) After filtering the medicinal liquid with a 200-mesh screen, the filtrate is placed in a container, and 1000 ml of medicinal liquid is collected, and the ethanol concentration is 52-60%;

[0051] (5) Add 50ml of camphor solution to the filtrate (dissolve 6.25g of camphor in 50ml of 60% ethanol solution, stir with a glass rod until there are no large camphor particles) and mix for 10 minutes;

[0052] (6) Put it into an analgesic active tincture bottle and send it for inspection.

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Abstract

The invention discloses a pain alleviating and collateral activating tincture composition and a preparation method thereof. The pain alleviating and collateral activating tincture has fixed content of more than or equal to 2.2 percent, comprises 23.8 [mu]g of chrysophanol and is prepared through the following steps: (1) weighing radix aconiti agrestis, pinellia ternata, monkshood, camphor, cape jasmine, rheum officinale, pawpaw, arisaema consanguineum schott, notopterygium root, radix angelicae tuhuo, beautiful sweetgum fruit, Chinese red pepper, hematoxylon, cattail pollen, lignum cinnamomi camphorae, red paeony root and red flower; (2) placing ethanol in a wide-mouth bottle, adding other 16 medicinal materials except for camphor and stirring; (3) then placing the wide-mouth bottle in a disintegration tester of which the temperature is regulated to 40 DEG C, performing still standing for 48 hours and stirring for 5 minutes each four hours during still standing; (4) filtering liquor through a 200-mesh screen, pouring the liquor into a container, then adding quantitive purified water into decoction dregs, stirring for 5 minutes, filtering and collecting the liquor; (5), then adding 50 ml of a camphor solution into the filtrate to mix for 10 minutes; (6) filling the obtained product into a pain alleviating and collateral activating tincture bottle and carrying out submission for inspection. The pain alleviating and collateral activating tincture disclosed by the invention has high total solid content and ensures that other indexes also can accord with the standard of the pain alleviating and collateral activating tincture.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical production, in particular to a high solid content analgesic active complex tincture composition and a preparation method thereof. Background technique [0002] Total solids, also known as total evaporation residues, are substances that remain when a water sample is evaporated and dried to constant weight under specified conditions. Calculated in milligrams of residue per liter of water. It is the sum of dissolved and suspended solids in water. The total solid content is the amount of the main active ingredients in each medicinal material in the analgesic active tincture, which is precipitated into the liquid, and the total solid content is directly related to the quality of the drug's use effect. It is also the content clearly specified in the quality standard of Analgesia Huoluo tincture. "The Pharmacopoeia of the People's Republic of China" stipulates that the total solid content in th...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P29/00A61P19/04A61P19/02A61P19/08A61P25/02A61K31/125
Inventor 李彤张永朱传海杨昌盛
Owner SHANGHAI JINGFENG PHARMA
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