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Detection method for Naoxinqing capsules

A detection method and capsule technology, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of differences in product efficacy and quality stability, and achieve the effects of avoiding the same detection standards, ensuring stability, and broad application prospects

Active Publication Date: 2014-04-30
余显维
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Problems solved by technology

However, due to differences in the origin, cultivation, and collection time of traditional Chinese medicines, there are large differences in the efficacy and quality stability of the products.

Method used

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  • Detection method for Naoxinqing capsules
  • Detection method for Naoxinqing capsules
  • Detection method for Naoxinqing capsules

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] Preparation of reference substance solution Take an appropriate amount of scopoletin reference substance, accurately weigh it, add methanol to make a reference substance solution;

[0045] Preparation of the test solution Take the contents of Naoxinqing capsules under the difference in loading amount, mix well, grind finely, accurately weigh, add methanol solution accurately, ultrasonically process, filter, and take the subsequent filtrate to obtain the test product solution;

[0046] Determination method Precisely absorb the reference substance solution and the test solution respectively, inject them into the liquid chromatograph, and measure; calculate the peak area according to the external standard method, and obtain the content of scopoletin;

[0047] Test Naoxinqing Capsules according to the above method. Each Naoxinqing Capsule contains no less than 5 μg of scopoletin. If the content of scopoletin in each capsule is less than 5 μg, the quality of the drug is unqual...

Embodiment 1

[0069] Embodiment 1 adopts the inventive method to detect Naoxinqing capsule

[0070] 1. Preparation of Naoxinqing Capsules

[0071] Preparation method: take dried persimmon leaves, add water to decoct twice, add 12 times the amount of water to decoct for 2 hours for the first time, add 10 times the amount of water to decoct for 1 hour for the second time, combine the decoction, filter, and concentrate the filtrate to relative The density is 1.12-1.15 (60°C), add ethanol until the alcohol content reaches 85%, let it stand overnight, and filter the supernatant for later use; the precipitate is washed twice with 4 times the amount of 65% ethanol each time, and the eluate is collected. Stand still, absorb the supernatant and combine with the previous supernatant, recover ethanol, add 2 times the amount of water to dissolve the obtained extract, filter, and use (3 times, 2 times, 2 times, 1 times) amount of ethyl acetate for the filtrate respectively Extract four times, combine t...

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Abstract

The invention relates to a detection method for Naoxinqing capsules, belongs to the technical field of traditional Chinese medicines and provides the detection method for the Naoxinqing capsules. Through the method, the quality of the Naoxinqing capsules can be better controlled. The method comprises the following step of carrying out scopoletin detection: using octadecylsilane chemically bonded silica as a filler, using methanol and 0.1 percent formic acid as flowing phases, adopting the detection wavelength of 345nm, taking a right amount of scopoletin reference sample, adding methanol to prepare into a reference solution, taking materials in the Naoxinqing capsules under the content uniformity item, precisely adding a methanol solution, carrying out ultrasonic processing, filtering, taking subsequent filtrate so as to obtain a test solution, respectively and precisely sucking the reference solution and the test solution, injecting the reference solution and the test solution into a liquid chromatograph, carrying out measurement, calculating by a peak area according to an external standard method so as to obtain the content of the scopoletin. The Naoxinqing capsules are detected according to the method, if the content of the scopoletin in each capsule is less than 5[mu]g, the drug is unqualified.

Description

technical field [0001] The invention relates to a detection method for Naoxinqing capsules, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Cardiovascular and cerebrovascular diseases are very common in clinical practice. At present, this type of disease is the number one killer of human health, and is listed by the World Health Organization as one of the overall priorities of the current organization-wide work. According to the data released by the World Health Organization, among the causes of human death, cardiovascular and cerebrovascular diseases account for 39.4% of the total death population, ranking first. Among human diseases, the recurrence rate of cardiovascular and cerebrovascular diseases is as high as 87%, ranking first. Among human diseases, the disability rate of cardiovascular and cerebrovascular diseases is as high as 50%, ranking first. This feature has brought great pain to countless families. [0003] A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 余显维刘艳李军李冬梅李文辉
Owner 余显维
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