Three-dimensional graphene/hydroxyapatite hydrogel material

Abstract

The invention provides a three-dimensional graphene / hydroxyapatite hydrogel material. The material is prepared in the following steps: mixing a graphene oxide solution with concentration of 6-10mg / ml and hydroxyapatite size, sufficiently and uniformly stirring to obtain a mixed solution, wherein the mass ratio of the graphene oxide to hydroxyapatite in the mixed solution is 1:(0.5-5); transferring the mixed solution into a hydrothermal reaction kettle, insulating for 0.5-24 hours at 160-200 DEG C to react; cooling to room temperature, and absorbing free water on the surface of the product to obtain the three-dimensional graphene / hydroxyapatite hydrogel material. The material is hydrogel with a network structure, is high in porosity, large in specific surface area and excellent in mechanical performance, can be directly used as bone tissue repairing materials and drug carriers with good treatment and repair effect and excellent drug-loading and drug-release effects.

Description

technical field [0001] The invention relates to a three-dimensional graphene / hydroxyapatite hydrogel material, belonging to nanocomposite materials and biological materials. Background technique [0002] Hydroxyapatite (HA) is a typical biomaterial, the main inorganic component of human bone tissue and teeth, has good biocompatibility and osteogenic activity, and is recognized as a good candidate in the field of bone repair and replacement Bone replacement biomaterials. However, as a bone repair material, hydroxyapatite also has disadvantages such as high brittleness, poor load bearing capacity, and inability to adapt well to different application requirements of clinical bone repair. To solve this problem, hydroxyapatite is often compounded with other materials to achieve the purpose of enhancing mechanical properties. [0003] Graphene (Graphene or Reduced-Graphene Oxide, RGO), as an emerging nano-scale material, has excellent electrical, mechanical, optical and thermal ...

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Problems solved by technology

The ethylenediamine used in this method is a substance that is harmful to human health. Its addition will reduce the biocompatibility of hydroxyapatite, resulting in the possibility of biotoxicity of the composite material.

And both of the above two methods need to process graphene oxide in the early stage to obtain graphene material or graphene precursor, and then form hydroxyapatite on it to obtain graphene / hydroxyapatite composite material, so Increase the reaction cycle and increase production costs, which is not conducive to large-scale production

Chinese patent CN201210055981.0 uses graphene oxide as a precursor and amino acid as a structural regulator to prepare graphene / hydroxyapatite nanocomposites by a hydrothermal method, but this method adds amino acids as a structural regulator, which increases the preparation cost, and Long reaction time, little sense for mass production

[0005] Moreover, the graphene / hydroxyapatite composite materials synthesized by the above method are all powders, and when used in the field of biological bone repair, they need to be pressed again, and the preparation of the porous structure is time-consuming, laborious, and costly. At the same time, the regulation process is complicated and repeatable It needs to be improved; as a drug sustained-release carrier material, because the three-dimensional grid structure is not formed, its porosity is not high enough, and its drug loading and drug release effects need to be improved

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