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Menatetrenone soft capsule and preparation method thereof

A technology of menadione and soft capsules is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, which can solve the problems of less excipients, allergies, dangers, etc., and achieve stable quality and simple preparation process. Effect

Inactive Publication Date: 2014-03-26
SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the patent uses polysorbate 80 and / or polysorbate 60 as a cosolvent, which has the risk of hemolysis; uses paraben preservatives, which can cause allergies and dermatitis
[0008] In view of the fact that the above two products are not suitable for long-term use, we still need to conduct further research on the prescription of menatetrenone soft capsules, and develop a preparation with less excipients, stable quality, safe and effective, and suitable for long-term use

Method used

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  • Menatetrenone soft capsule and preparation method thereof
  • Menatetrenone soft capsule and preparation method thereof
  • Menatetrenone soft capsule and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] Embodiment 1: menadione tetraenol soft capsules

[0031] 1) Prescription composition:

[0032] Liquid composition: 150g menatetrenone, 400g soybean oil, 450g polyglycerol oleate;

[0033] Capsule composition: 10kg gelatin, 6kg glycerin, 12kg water, 10g sunset yellow, 100g titanium dioxide.

[0034] 2) Preparation method:

[0035] a. The preparation of the capsule skin solution, adding water, glycerin, sunset yellow, and titanium dioxide into the rubber barrel, raising the temperature to 70°C, adding gelatin after reaching the temperature, making it completely dissolved, and keeping it warm for later use;

[0036] b. Preparation of medicinal solution: mix and dissolve menatetrenone, soybean oil, and polyglyceryl oleate, and set aside;

[0037] c. Pressed soft capsules: press the soft capsules with the above liquid medicine and capsule skin solution, dry, pack, and each capsule contains 15 mg of menadione.

Embodiment 2

[0038] Embodiment 2: menadione tetraenol soft capsules

[0039] 1) Prescription composition:

[0040] Liquid composition: 150g of menaquinone, 500g of peanut oil, 200g of polyglycerol oleate, 150g of oleic acid macrogol glyceride;

[0041] Composition of capsule skin: 10kg of gum arabic, 5kg of sorbitol, 10kg of water, 120g of titanium dioxide.

[0042] 2) Preparation method:

[0043] a. The preparation of the capsule skin solution, adding water, sorbitol, and titanium dioxide into the rubber barrel, raising the temperature to 75°C, adding gum arabic after reaching the temperature, making it completely dissolved, and keeping it warm for later use;

[0044] b. Preparation of medicinal solution: mix and dissolve menatetrenone, peanut oil, polyglycerol oleate, and macrogol glycerol oleate, and set aside;

[0045] c. Pressed soft capsules: press the soft capsules with the above liquid medicine and capsule skin solution, dry, pack, and each capsule contains 15 mg of menadione....

Embodiment 3

[0046] Embodiment 3: menadione tetraenol soft capsules

[0047] 1) Prescription composition:

[0048] Liquid composition: 150g of menaquinone, 450g of soybean oil, 200g of polyglycerol oleate, 175g of oleic acid macrogol glyceride;

[0049]Capsule composition: gelatin 10kg, glycerin 5kg, water 9kg, titanium dioxide 120g.

[0050] 2) Preparation method:

[0051] a. Preparation of the capsule skin solution, adding water, glycerin, and titanium dioxide into the plastic barrel, raising the temperature to 75°C, adding gelatin after reaching the temperature, making it completely dissolved, and keeping it warm for later use;

[0052] b. Preparation of medicinal solution: mix and dissolve menatetrenone, soybean oil, polyglycerol oleate, and macrogol glycerol oleate, and set aside;

[0053] c. Pressed soft capsules: press the soft capsules with the above liquid medicine and capsule skin solution, dry, pack, and each capsule contains 15 mg of menadione.

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Abstract

The invention provides a menatetrenone soft capsule and a preparation method thereof. The menatetrenone soft capsule is composed of a capsule skin and liquid medicine, wherein the liquid medicine is composed of menatetrenone, vegetable oil and a cosolvent in the weight ratio of 1: (2-7): (0.2-4); few accessories are used for the menatetrenone soft capsule provided by the invention; and the menatetrenone soft capsule is simple in preparation process, stable in quality, safe and effective, and suitable for clinical use and large-scale production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical preparation of menadione and a preparation method thereof, in particular to a menatetrenone soft capsule and a preparation method thereof. Background technique [0002] Vitamin K is a class of compounds with a quinone structure, including five types of compounds with different structures, namely vitamin K1, K2, K3, K4, and K5. Studies have shown that vitamin K2 has an osteogenic effect, promotes calcium metabolism, and can also inhibit bone resorption caused by osteoclasts, thereby increasing bone density and preventing osteoporosis. [0003] Vitamin K2 is a series of compounds, which are pale yellow crystals and are mainly synthesized by intestinal bacteria. There are 14 types according to the length of the isoprene side chain on C3. Vitamin K2 is mainly used to treat osteoporosis (20 ), that is, menatetrenone. The structure of menatetrenone is shown ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/122A61P3/02A61P19/10
Inventor 牛锋韩霜齐军彩李影秦月伟
Owner SHIJIAZHUANG PHARMA GRP NBP PHARMA CO LTD
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