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Method for extracting refined chicoric acid

A technology of cichoric acid and extract, which is applied in the separation/purification of carboxylic acid esters, organic chemistry, etc., can solve the problems of low purity of later products, large loss of active ingredients, and low removal rate of impurities, and achieve rapid adsorption and high adsorption capacity. Large, selective effect

Inactive Publication Date: 2014-03-19
XINJIANG TERUI BIOTECH
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Problems solved by technology

[0008] Aiming at the deficiencies in the prior art, the invention provides a method for extracting and refining cichoric acid. During the extraction process of cichoric acid, ultrasonic wave is used to assist to improve the extraction rate of cichoric acid; and the problem of low extraction rates
The macroporous resin adsorption technology is used to replace the traditional alcohol extraction and water precipitation technology to remove impurities in the alcohol extract and enrich the active ingredients; it solves the problems of low impurity removal rate, large loss of active ingredients and low purity of later products in the traditional technology.

Method used

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  • Method for extracting refined chicoric acid
  • Method for extracting refined chicoric acid

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Embodiment Construction

[0026] Such as figure 1 Shown, a kind of method for extracting refined cichoric acid, comprises the steps:

[0027] 1) the dried Echinacea purpurea is cut into short sections of length 2-3cm with a medicine cutter, and put into a multifunctional extraction tank with an ultrasonic generator;

[0028] 2) Add 60% ethanol to the extraction tank that has been fed for extraction, and extract twice in total. During the extraction process, stir the whole process at a stirring speed of 20 rpm; the volume ratio of the solid to liquid for the two extractions is 1 :8, the second time is 1:7, the extraction time is 50min for the first time, and 30min for the second time; the extraction temperature is 50℃, and the power of the ultrasonic generator is 200W.

[0029] 3) After the extract is filtered through the plate frame, it is concentrated with a vacuum concentrator at a concentration temperature of 70°C, and the ethanol is recovered until the concentrated solution is 1 / 10 of the volume o...

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Abstract

The invention discloses a method for extracting refined chicoric acid. According to the method, echinacea raw materials are treated by steps of extracting by ultrasonic waves, decompressing and concentrating in vacuum, sampling macroporous resin, washing with de-ionized water, eluting, decompressing and concentrating in vacuum, spraying and drying, detecting, crushing, and packaging and storing. In the extraction process of the chicoric acid, ultrasonic wave assisting is utilized to improve the extraction rate of the chicoric acid; the problems that the extraction time in the extraction process is long and the extraction rate is low are effectively improved; a macroporous resin adsorption technology is used for removing impurities in an alcohol extracting solution and effective components are enriched; the problems that in the prior art, the impurity removing rate is low, the loss of effective components is great, the purity of later-period products is low and the like are solved.

Description

technical field [0001] The invention relates to a method for extracting and refining cichoric acid, in particular to a method for extracting and refining cichoric acid from Echinacea purpurea by ultrasonic technology and refining cichoric acid with a macroporous adsorption resin. Background technique [0002] Chicoric acid belongs to phenolic acids, the chemical name is (2R,3R)-2,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl] Oxy]succinic acid, molecular formula C 22 h 18 o 12 , the molecular weight is 474.37, and its chemical structural formula is: [0003] [0004] Chichoric acid is one of the extremely important immune active ingredients in chicory and echinacea. Pharmacological studies in recent years have shown that cichoric acid can enhance immune function and anti-inflammatory effects, and can inhibit hyaluronidase, protect collagen from free radicals that can cause degradation, and also inhibit HIV-1 and HIV-1 Integrase action. [0005] At present, domestic...

Claims

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Application Information

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IPC IPC(8): C07C69/732C07C67/48
CPCC07C67/48C07C69/732
Inventor 薛亚峰薛振汉姚亚龙
Owner XINJIANG TERUI BIOTECH
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