Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of biofilm device for wound surface and preparation method thereof

A biofilm and wound technology, applied in the field of medical materials, can solve the problems of high cost of treatment, pain of patients, complex artificial skin, etc., and achieve the effect of simple and easy-to-use equipment, less labor, and uncomplicated preparation process

Inactive Publication Date: 2016-01-27
曲凯明
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Not only the cost of treatment is expensive, but more importantly, it brings great pain to patients
In addition, for patients with extensive burns, skin grafting is required, and there are very few good skins of their own, so artificial skins must be used, which is more complicated to make

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of biofilm device for wound surface and preparation method thereof
  • A kind of biofilm device for wound surface and preparation method thereof
  • A kind of biofilm device for wound surface and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: to the therapeutic effect of scald and pathological examination result

[0038]Take 36 mice with a body weight of 20-24g, and divide them into 3 groups randomly, 12 mice / group; depilate the back with 10% sodium sulfide, and use 80°C water to cause II degree burns with an area of ​​1.4×1.4cm. The first group of mice used the biofilm device as the experimental group; the second group of mice used Jingwanhong scald medicine as the positive control group, and the third group of mice used everything as the blank control group.

[0039] The results showed that: 1. The experimental group and the positive control group began to grow scabs on the second day. After 4-7 days, the scabs on the skin of all mice came off, and the new granulation was ruddy, and hairs gradually grew. 2. The positive control group (i.e. the first group) is slower than the experimental group (i.e. the second group); 3. The blank control group (i.e. the third group) is at the initial stage o...

Embodiment 2

[0044] Example 2: Effects on Vascular Permeability of Scalded Rats

[0045] Take 20 white rats weighing 180-200g, anesthetize them by intraperitoneal injection of 1g / kg Uradum, fix the back, wash with 10% sodium sulfide abdominal hair removal saline and wait until dry, inject 1% Evans blue 0.2mL / rat sublingually Immediately use 80°C water to mark three symmetrical scald surfaces of 1.4×1.4cm on the abdomen, one is the blank control group (no drug application), one is the experimental group (that is, where the biofilm device is used), and one is the positive control group (i.e. use Jingwanhong scald medicine), observe the degree of blue staining on the scalded surface after 1 hr and 2 hr respectively after applying the scald medicine or biofilm, measure and calculate the blue staining area, the results are shown in the table below:

[0046]

[0047] *P<0.01 compared with the control group

[0048] It can be seen that the biofilm device can significantly reduce the vascular ...

Embodiment 3

[0049] Example 3: Anti-inflammatory effect

[0050] Thirty white rats with a body weight of 200-220 g were randomly divided into 2 groups, 15 rats per group, and the circumference of the ankle joints and soles of the two hind feet were measured. Subcutaneously inject 20% fresh egg 0.1mL / foot into the ankle joint from the palmar aponeurosis of the foot, and the right hind foot is used as the experimental group. The right hind foot of one group of rats is immediately pasted with the biofilm in the biofilm device, and the right hind foot of the other group of rats is immediately pasted with biofilm in the biofilm device. Immediately apply Jingwanhong scald medicine to the right hind foot, and repeat the film or drug application every 0.5hr. The left hind feet of all the rats in the above two groups are used as the blank control group. At 0.5hr, 1hr, and 2hr after egg white injection, the two hindfoot joints and the meridians of the soles were re-measured, and the degree of inflam...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a biological membrane device used for a wound surface. The biological membrane device comprises a biological membrane and protective liquid, wherein the biological membrane is prepared from an animal foetal membrane, and is an outer coating membrane for protecting the wound surface from being infected; proactive liquid is prepared from peroxyacetic acid, alcohol and normal saline. A preparation method of the biological membrane device comprises the following steps: (1), taking down an amniotic membrane from the foetal membrane, and flushing; (2), removing chorion and appendages thereof, flushing again, soaking, stewing, flushing by sterile liquid to obtain the biological membrane; (3), preparing the protective liquid; (4), soaking the biological membrane in the protective liquid, and carrying out ultraviolet sterilization treatment, and filling the biological membrane into a packaging bag injected with the protective liquid to obtain the biological membrane device. The biological membrane has characteristics of good toughness, elasticity and gas permeability, and is not repulsive with the wound surface and strong in coating performance; the protective liquid has effects of resisting inflammation, restraining bacteria or sterilizing, and keeping a sterile environment for the wound surface, and can be used for cleaning and protecting the biological membrane. The biological membrane device disclosed by the invention is a biological technology which is the most advanced in China at present.

Description

technical field [0001] The invention relates to a medical material in the field of medicine, in particular to a biofilm device for wounds and a preparation method thereof. Background technique [0002] Skin injuries caused by flames, hot solids, chemicals, intense radiant heat, and electricity are called burns. The degree of burn is different by the height of temperature, the length of action time. When the burned skin reaches more than 1 / 3rd of the whole body surface area, it can be life-threatening. [0003] Clinically, the severity of burn depends on the scope and depth of injured tissue, and the depth of burn can be divided into I degree, II degree and III degree. First-degree burns are the lightest, with redness, pain, obvious tenderness, oozing or edema on the burned skin, and partial whitening when the injured part is lightly pressed, but no blisters; second-degree burns are deeper, with blisters on the skin and the bottom of the blisters It is red or white, filled...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/40A61L15/42A61K33/14A61K31/327A61P17/02A61P31/04A01N37/16A01P1/00
Inventor 汪洋李国义
Owner 曲凯明
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com