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Preparation method and application of liver-restoring tablet

A technology of Liganlong tablets and Yinchen, which is applied in the field of preparation of Liganlong tablets, can solve the problems of large dosage, backwardness, and many impurities in patients, and achieve the effect of reducing the dosage.

Active Publication Date: 2014-02-26
海宁市钱塘新农村开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Liganlong Tablets. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the This product is used clinically

Method used

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  • Preparation method and application of liver-restoring tablet

Examples

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Comparison scheme
Effect test

Embodiment 1

[0016] Take 800g of Radix Isatidis, 166g of Yinchen, 266g of Curcuma, 266g of Schisandra, 266g of Licorice, 133g of Angelica, 400g of Astragalus, and 20g of Acanthopanax into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take 800g of Radix Isatidis, 166g of Yinchen, 266g of Curcuma, 266g of Schisandra, 266g of Licorice, 133g of Angelica, 400g of Astragalus, and 20g of Acanthopanax into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take 800g of Radix Isatidis, 166g of Yinchen, 266g of Curcuma, 266g of Schisandra, 266g of Licorice, 133g of Angelica, 400g of Astragalus, and 20g of Acanthopanax into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

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Abstract

The invention provides a preparation method for a liver-restoring tablet. The liver-restoring tablet is prepared from the bulk drugs consisting of 800 g of isatis root, 166 g of oriental wormwood, 266 g of curcuma tuber, 266 g of Chinese magnoliavine, 266 g of licorice, 133 g of Chinese angelica, 400 g of milk vetch and 200 g of acanthopanax root through supercritical extraction. With the preparation method, the content of the bulk drugs in the liver-restoring tablet is greatly increased, and the dose of the tablet is reduced. The invention further provides application of the liver-restoring tablet in preparation of drugs used for inhibiting cell proliferation of the mouse melanoma lung metastasis strain B16-F10.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Liganlong tablets. Background technique [0002] Liganlong tablets are recorded in the standard WS3-B-0281-90 of the Ministry of Health, and the prescription is 800g of Radix Radix, 166g of Capillary, 266g of Curcuma, 266g of Schisandra, 266g of Licorice, 133g of Angelica, 400g of Astragalus, 20g of Acanthopanax, and the above eight flavors , take 130g of Radix Radix and pulverize into fine powder; another take Schisandra chinensis, dry, pulverize into coarse powder, add 75% ethanol and heat and reflux to extract three times, each time for 3 hours, the second time for 2 hours, every three times for 1 hour, combine the extracts, filter After filtration, the ethanol was recovered from the filtrate and concentrated to a clear ointment with a relative density of 1.30-1.32 (80°C); additionally, capillary, angeli...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/20A61P1/16A61P35/04
Inventor 李强
Owner 海宁市钱塘新农村开发有限公司
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