Preparation method of veterinary albendazole/ivermectin dry suspension

Abstract

The invention relates to a veterinary anthelmintic, and particularly relates to a veterinary albendazole / ivermectin dry suspension with using convenience and significant drug effects, and a preparation method of the dry suspension. The preparation method comprises steps of stirring 0.1-0.2 part of ivermectin and 2-4 parts of sodium carboxymethylcellulose and mixing, adding 2-4 parts of a flavoring agent after the powder is mixed uniformly, and mixing uniformly again; stirring 5-15 parts of albendazole and 10-20 parts of sodium chloride and mixing, adding 5-10 parts of sodium citrate after the powder is mixed uniformly, and mixing uniformly again; adding the former into the latter through an equivalent increment method, and stirring uniformly; adding the balance of other auxiliary material and further uniformly stirring and mixing; and subpackaging to obtain a finished product. The other auxiliary material is soluble starch or microcrystalline cellulose. The dry suspension can be proportionally added in an automatic drinker directly for use, thus facilitating all-round dosing in a large-size livestock farm. The dry suspension avoids the toxic and side effect caused by non-uniform feed mixing, and is more convenient to use. The drug effect is remarkably enhanced, and the cost is obviously lowered in comparison with the prior art. The dry suspension has a wide application prospect.

Description

[0001] This application is a divisional application of the invention patent with the application number: 201210145706.8 and the patent name: "veterinary albendazole ivermectin powder". The original application date: May 10, 2012. technical field [0002] The invention relates to a veterinary anthelmintic, and also relates to veterinary albendazole and ivermectin. Background technique [0003] Albendazole, a benzimidazole anti-helminth drug, has broad-spectrum anthelmintic activity, and has a strong killing effect on nematodes, tapeworms, and trematodes in livestock and poultry. Its mechanism of action is to bind to tubulin in worms and prevent it from multimerizing with α-tubulin to form microtubules, thereby affecting cell reproduction processes such as mitosis, protein assembly and energy metabolism in worms, and inhibiting The purpose of parasite growth and reproduction. [0004] Ivermectin has a good killing effect on internal and external parasites, especially arthrop...

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Problems solved by technology

[0007] In the prior art, there have also been reports of compounding albendazole and ivermectin into compound preparations, for example, the application number is 200710150563.9 and the application number is 201010242809.7 It has been reported, but these preparations all have the problem that the drug efficacy is still low, and they are all dry powders used for mixing with feed, and there is still the risk of poisoning accidents caused by uneven mixing of ivermectin in feed

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