Preparation method of albendazole/ivermectin powder for livestock

Abstract

The invention relates to an anthelmintic drug for livestock, and particularly relates to a preparation method of albendazole / ivermectin powder for livestock, which is convenient to use and remarkable in drug effect. The preparation method comprises the following steps: stirring and mixing 0.1-0.2 part of ivermectin and 2-4 parts of sodium carboxymethyl cellulose, adding 2-4 parts of flavoring agent after the powder is evenly mixed, and further evenly mixing; stirring and mixing 5-15 parts of albendazole and 10-20 parts of sodium chloride, adding 5-10 parts of sodium citrate after the powder is evenly mixed, and further evenly mixing; and then, adding the former into the latter through an equivalent increment method, evenly stirring, adding the balance of other auxiliary material, further evenly stirring and mixing, and subpackaging to obtain the finished product, wherein the other auxiliary material is soluble starch or microcrystalline cellulose. The drug provided by the invention is a dry suspension, can be proportionally added in a drinking fountain directly for use, and facilitates the all-round dosing in a large-size livestock farm; the drug avoids the toxic and side effect caused by uneven feed mixing and is more convenient to use; and the drug effect is remarkably enhanced, and the cost is obviously lowered in comparison with the prior art, thereby ensuring that the drug has wide application prospects.

Description

technical field [0001] The invention relates to a veterinary anthelmintic, and also relates to veterinary albendazole and ivermectin. Background technique [0002] Albendazole, a benzimidazole anti-helminth drug, has broad-spectrum anthelmintic activity, and has a strong killing effect on nematodes, tapeworms, and trematodes in livestock and poultry. Its mechanism of action is to bind to tubulin in worms and prevent it from multimerizing with α-tubulin to form microtubules, thereby affecting cell reproduction processes such as mitosis, protein assembly and energy metabolism in worms, and inhibiting The purpose of parasite growth and reproduction. [0003] Ivermectin has a good killing effect on internal and external parasites, especially arthropod insects and internal nematodes, and is mainly used to expel gastrointestinal nematodes, lung nematodes and external parasites in pigs and other animals. Its deworming mechanism is to promote the release of γ-aminobutyric acid (GA...

AI Technical Summary

Problems solved by technology

The above drugs need to be used in combination to completely drive away internal and external parasites. Repeated use of drugs not only wastes resources, but also increases the labor of the breeders

Moreover, the above-mentioned dosage forms are used for oral administration and mixed feeding. Patients often have difficulty swallowing and are unwilling to take the medicine. However, because the dosage of ivermectin premix is ​​very small, it often cannot be mixed evenly when used in mixed feed. accident of poisoning

[0006] In the prior art, there have also been reports of compounding albendazole and ivermectin into compound preparations, such as application number 200710150563.9 and application number 201010242809.7, but these preparations still have relatively low efficacy problems, and they are all dry powders used for mixing with feed, there is still the risk of poisoning accidents caused by uneven mixing of ivermectin in feed

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