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W/O microemulsion, and preparation method and applications thereof

A technology of microemulsion and microemulsion, applied in the field of formulations, can solve problems such as high cost and complicated preparation process

Inactive Publication Date: 2014-02-26
YANCHENG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of these methods is more complicated and the cost is higher.

Method used

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  • W/O microemulsion, and preparation method and applications thereof
  • W/O microemulsion, and preparation method and applications thereof
  • W/O microemulsion, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1 A kind of W / O microemulsion

[0088] Raw material formula: (unit: g)

[0089]

[0090] Prepared by:

[0091] First mix ethanol with water to obtain an aqueous phase solution; under the condition of continuous stirring by a magnetic stirrer, the rotation speed is 600rpm, add Span80 and Tween80 to the mixing kettle, then add the aqueous phase solution, and finally add iso-myristic acid Propyl ester until the mixed system is clear and transparent.

Embodiment 2

[0092] Example 2 A kind of W / O microemulsion

[0093] Raw material formula: (unit: kg)

[0094]

[0095] Prepared by:

[0096] First mix ethanol with water to obtain an aqueous phase solution; under the condition of continuous stirring by a magnetic stirrer, the rotation speed is 400rpm, add Span80 and Tween80 to the mixing kettle, then add the aqueous phase solution, and finally add iso-myristic acid Propyl ester until the mixed system is clear and transparent.

Embodiment 3

[0097] Example 3 A kind of W / O microemulsion

[0098] Raw material formula: (unit: g)

[0099]

[0100] Prepared by:

[0101] First mix ethanol with water to obtain a water phase solution; under the condition of continuous magnetic stirring, the rotation speed is 250rpm, add Span80 and Tween80 into the mixing kettle, then add the water phase solution, and finally add isopropyl myristate ester until the mixed system is clear and transparent.

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Abstract

The invention provides a W / O microemulsion with stable properties and a particle size less than 100nm. The weight of the W / O microemulsion is taken as a standard, the W / O microemulsion comprises, by weight, 10 to 42% of a complex emulsifier, 2 to 40% of an aqueous solution, and the balance isopropyl myristate; the complex emulsifier is made from Span80 and Tween80 at a weight ratio of 1.02-1.27:1; and the aqueous solution is formed by water and ethanol at a weight ratio of 1-3:1. The invention also provides a preparation method and applications of the W / O microemulsion. The preparation method of the W / O microemulsion is simple; and the W / O microemulsion is an excellent carrier of active substances or functional substances which possess poor stability and lipid solubility, and are represented by tea polyphenol, and is capable of increasing stability of the active substances or the functional substances in food and medicinal preparations, and improving slow release behavior of the active substances or the functional substances.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a food-grade W / O microemulsion, a preparation method thereof, and an application as a carrier in food and pharmacy. Background technique [0002] Tea polyphenols is the general term for polyphenols in tea, including flavanols, anthocyanins, flavonoids, flavonols and phenolic acids, etc. It is one of the important active ingredients in tea and has many physiological activities and pharmacological effects. It has excellent antioxidant properties and the ability to significantly scavenge free radicals. Its antioxidant capacity is 4-6 times that of synthetic antioxidants BHT and BHA, 6-7 times that of VE, and 5-10 times that of VC. It is a new type of natural Antioxidants. However, the poor fat solubility of tea polyphenols hinders its application in lipophilic systems, especially in the food oil industry. In addition, tea polyphenols have poor stability and are prone to reacti...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/26A61K47/10A61K47/14A61K36/82A61P39/06A23L1/29A23L1/302A23L33/00A23L33/15
Inventor 颜秀花许伟邵荣唐兰勤陈立根
Owner YANCHENG INST OF TECH
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