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A technology of compounds and drugs, applied in the field of preparation of drugs for the prevention and treatment of cancer pain, which can solve the problems of limited opioid effect, gastrointestinal damage or kidney damage, and decreased analgesic effect of morphine
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[0008] Example 1. Evaluation of Drug Efficacy for Alleviating Cancer Pain
[0009] Animal modeling: After the animal was anesthetized, the left hind limb was sheared, the skin of the femur and tibia was disinfected with 75% ethanol, and a skin incision about 0.5-1.0 cm long was made at the knee joint along the direction of the rectus femoris tendon to carefully expose the patella. Use a disposable sterile 1mL syringe needle to puncture the patella along the long axis of the femur, then replace it with a 10μL syringe into the femoral medullary cavity, and slowly inject 10μL of Lewis mouse lung cancer cell solution (containing 3×10 5 cells) to the femur. After the injection, the needle hole was sealed with bone wax, the wound was cleaned, and the skin was sutured. The left patella of the animals in the sham operation group was injected with an equal volume of normal saline, and the rest of the operations were the same as those in the model group, while the blank group received ...
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