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Application of silvery aleuritopteris herb extract in preparation of anticancer drugs

An anticancer drug and a technology of Tongjingcao, applied in the field of biomedicine, can solve the problems such as no reports on the anticancer drugs of Tongjingcao or Tongjingcao extract.

Inactive Publication Date: 2014-02-19
周杰华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned literature and patents, etc., have not yet seen the report of Tongjingcao or Tongjingcao extract being used to prepare anticancer drugs

Method used

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  • Application of silvery aleuritopteris herb extract in preparation of anticancer drugs
  • Application of silvery aleuritopteris herb extract in preparation of anticancer drugs
  • Application of silvery aleuritopteris herb extract in preparation of anticancer drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Preparation of Tongjingcao Extract and Monomer Compounds

[0038] (1) 20kg of Herba Trichonia, using 70% ethanol as a solvent, soaking and extracting at 70°C, extracting twice, each extraction time is 2 hours, and the amount of solvent used each time is 12 times the weight of Herbs of Herbs; filter , combine the extracts, recover ethanol, concentrate, and dry to obtain Tongjingcao extract A;

[0039] (2) Add 10 times the amount of water to dissolve the Tongjingcao extract A obtained in step (1), and filter to obtain medicinal solution A and precipitate A. The precipitate A is separated and purified by high-speed countercurrent chromatography (HSCCC) using cyclohexane-ethyl acetate-methanol-water (3:2:2:1) as the solvent system, the solvent is recovered, concentrated and dried to obtain Tongjingcao Extract B;

[0040] (3) Pass the medicinal solution A obtained in step (2) through a HPD600 macroporous adsorption resin column, elute with water, and then elute ...

Embodiment 2

[0044] Example 2: Preparation of Tongjingcao Extract and Monomer Compounds

[0045] (1) 20kg of Herba Trichonia, using 90% ethanol as a solvent, warm-immersed and extracted at 50°C, the number of extractions is 3 times, each extraction time is 1 hour, and the amount of solvent used each time is 15 times the weight of Herba Trichonia; Filtrate, combine the extracts, recover ethanol, concentrate, and dry to obtain Tongjingcao extract A;

[0046] (2) Add 20 times the amount of water to dissolve the Tongjingcao extract A obtained in step (1), and filter to obtain medicinal solution A and precipitate A. The precipitate A is separated and purified by high-speed countercurrent chromatography (HSCCC) using cyclohexane-ethyl acetate-methanol-water (3:2:2:1) as the solvent system, the solvent is recovered, concentrated and dried to obtain Tongjingcao Extract B;

[0047] (3) Pass the drug solution A obtained in step (2) through an AB-8 macroporous adsorption resin column, elute with wa...

Embodiment 3

[0051] Example 3: Preparation of Tongjingcao Extract and Monomer Compounds

[0052] (1) 5 kg of Herba Trichonia, using 50% ethanol as a solvent, warm-soaked and extracted at 80°C, the number of extractions was once, and the extraction time was 4 hours each time, and the amount of solvent used each time was 6 times the weight of Herba Trichonia; Filtrate, combine the extracts, recover ethanol, concentrate, and dry to obtain Tongjingcao extract A;

[0053] (2) Add 5 times the amount of water to dissolve the Tongjingcao extract A obtained in step (1), and filter to obtain medicinal solution A and precipitate A. The precipitate A is separated and purified by high-speed countercurrent chromatography (HSCCC) using cyclohexane-ethyl acetate-methanol-water (3:2:2:1) as the solvent system, the solvent is recovered, concentrated and dried to obtain Tongjingcao Extract B;

[0054] (3) Pass the drug solution A obtained in step (2) through an LSA-40 macroporous adsorption resin column, e...

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Abstract

The invention discloses a new use of a sivery aleuritopteris herb extract, and the new use is the application of the silvery aleuritopteris herb extract in preparation of anticancer drugs. The silvery aleuritopteris herb extract is prepared by the following method: extracting silvery aleuritopteris herb as a raw material with 50%-90% ethanol, and then using high-speed counter current chromatography, macroporous adsorption resin and the like for chromatography purification to obtain the silvery aleuritopteris herb extract. The silvery aleuritopteris herb extract has important significance in preparation of the anticancer drugs, especially anti liver cancer, anti lung cancer, and anti-gastric cancer drugs.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of an extract of Chinese medicinal materials in the preparation of anticancer drugs, in particular to the application of the extract of Tongjingcao in the preparation of anticancer drugs. Background technique [0002] According to statistics from the Ministry of Health in February 2010, the number of cancer deaths worldwide reaches 10 million each year. At present, one-quarter of the global population's death is caused by cancer, and it is predicted that if the current trend continues, one-half of the deaths will be due to cancer by 2050. The incidence of malignant cancer in my country is increasing at a rate of 2.5-5% per year, and it has become the culprit that seriously endangers human life. Among various types of cancer, lung cancer, gastric cancer, and liver cancer have higher incidence rates. [0003] Blood vessels are necessary for the formation and function main...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61K31/7048A61P35/00A61K31/352
Inventor 孔倩倩
Owner 周杰华
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