Efficient antibacterial activity antisense nucleic acid sequence of multidrug resistant Acinetobacter baumannii
A kind of Acinetobacter baumannii, multi-drug resistance technology, used in antibacterial drugs, pharmaceutical formulations, recombinant DNA technology and other directions
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[0018] 1: Synthesis of antisense nucleic acid
[0019] In order to keep the stability of the antisense nucleic acid in the research, it is not easy to be degraded and lose the inhibitory effect, the antisense nucleic acid is synthesized in the form of peptide nucleic acid (PNA) to increase its stability, and the sequence modification of the penetrating peptide KFFKFFKFFK is added to overcome the The bacterial membrane structure acts as a barrier to macromolecules, so as to achieve the purpose of transferring the antisense sequence into the bacterial body in a stable form.
[0020] Peptide nucleic acid (PNA) is an artificially synthesized DNA analog, which replaces the 3', 5' phosphodiester bonds of the natural nucleic acid backbone with peptide bonds (NH-CO), and has high water solubility, high stability, and specificity for base pairing. Sexual characteristics. However, the molecular weight of peptide nucleic acid is much larger than that of commonly used drugs, which makes ...
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