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Pepper nano powder, pepper supported nano powder as well as preparation method and application thereof

A technology of Zanthoxylum bungeanum nanopowder and Zanthoxylum bungeanum, applied in its derivative preparation, preparation, loading Zanthoxylum bungeanum nanopowder, Zanthoxylum bungeanum nanopowder, can solve the problems of volatile loss of active ingredients, difficulty in industrial production, high production cost, etc., to improve drug efficacy, The preparation method is simple and the production cost is low

Inactive Publication Date: 2014-02-12
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the field of medicine or health products, pepper is usually extracted from the pepper oil or made into pepper essence. For example, in China, the refined processing of pepper is mainly to use steam distillation and solvent extraction to extract the volatile oil and oleoresin, or to make powder, or directly use volatile oil and oleoresin, but the active ingredients are extremely volatile and lost, such as Chinese patent application 200410022488 "Production process of microencapsulated pepper powder and linolenic acid powder"
There are also commercially available supercritical CO 2 Microcapsule products prepared by extraction as the main technology have stable quality, but require high equipment and are difficult to produce industrially. At the same time, the production cost is high, and the sales market is still biased towards higher consumption levels. It is difficult to be accepted by ordinary consumers for a while.
[0004] The inventor found that the active ingredients of the existing Zanthoxylum bungeanum graded products, Zanthoxylum bungeanum powder, Zanthoxylum bungeanum oil products, including volatile oil, flavonoids, etc., usually lose more than 50% in about 3 months

Method used

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  • Pepper nano powder, pepper supported nano powder as well as preparation method and application thereof
  • Pepper nano powder, pepper supported nano powder as well as preparation method and application thereof
  • Pepper nano powder, pepper supported nano powder as well as preparation method and application thereof

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preparation example Construction

[0052] The preparation method of Zanthoxylum bungeanum nanopowder of the present invention is as follows:

[0053] 1) Zanthoxylum bungeanum is crushed to 20-60 mesh by ordinary grinder;

[0054] 2) Grinding to the micron level with an ultrafine pulverizer, and controlling the temperature to 10-45°C for 3-6 hours;

[0055] 3) Use a ball mill to pulverize to the nanometer level, and control the temperature to 10-45°C for 6-10 hours;

[0056] 4) Use a high-pressure homogenizer to pulverize, control the temperature to 10-45°C, 20-60Mpa, homogenize 1-6 times, 30 minutes each time. Wherein, when pulverizing with an ultrafine pulverizer, a ball mill, or a high-pressure homogenizer, the temperature is preferably 20-25° C.

[0057] As the number of homogenization increases, the smaller the particle size of the nanopowder, the higher the wall breaking rate. When the particle size of Zanthoxylum bungeanum powder is less than 1000nm, the wall breaking rate is at least greater than 80%;...

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Abstract

The invention belongs to the fields of food, health care products and mediciaments and in particular relates to pepper nano powder, pepper supported nano powder, a derivative preparation of the pepper nano powder as well as a preparation method and application of the pepper nano powder. The invention aims at solving the technical problem of providing a brand new pepper application form, comprising pepper nano powder, pepper supported nano powder and a derivative product of the pepper nano powder and used for food, health care products and medicaments. The pepper nano powder has the characteristics that the grain size of the pepper nano powder is less than 1000nm, and wall-broken rate is at least more than 80%; further at least one supporter of chitosan, chitin, beta-cyclodextrin and sodium alginate is supported on the pepper nano powder by adopting high pressure, thus the pepper supported nano powder is obtained; finally a preparation can be prepared according to a pharmaceutically acceptable manner by adopting the pepper nano powder or / and pepper supported nano powder as active ingredients; the improvement effect is obvious when the pepper nano powder and pepper supported nano powder product forms are applied to hypolipidemic and indications caused by hyperlipidemia.

Description

technical field [0001] The invention belongs to the fields of food, health care products and medicines, and in particular relates to Zanthoxylum bungeanum nanopowder, loaded Zanthoxylum bungeanum nanopowder, derivative preparations thereof, preparation methods and uses thereof. Background technique [0002] Zanthoxylum bungeanum is the dried or fresh peel of Zanthoxylum bungeanum in Rutaceae. As a traditional seasoning and traditional Chinese medicine, Zanthoxylum bungeanum has a long history of application. In 2002, the Ministry of Health confirmed that Zanthoxylum bungeanum is a dual-purpose raw material for medicine and food. "Shen Nong's Materia Medica" records that "Shujiao is pungent and warm. It controls evil cough, warms the middle, dispels the dead muscles of the joints and skin, causes cold and damp arthralgia, and lowers the qi. The head will not turn white after long-term use, and the body will increase the age." "Materia Medica" "Compendium" records that Zanthox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61K47/36A61K47/40A61K9/14A61P3/06A23L1/223A23L1/29A23L27/14A23L33/00
Inventor 黄文何杨杜丹石应康
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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