Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of preparation method and application of Shishu camphor extract

An extract, a technology of dozens of camphor, applied in the field of ethnic medicine, to achieve the effect of improving oral ulcers

Active Publication Date: 2016-06-08
WUHAN BOTANICAL GARDEN CHINESE ACAD OF SCI
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparation and characterization method of the antibacterial active extract of Uganda Shishu Cinnamomum camphora

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method and application of Shishu camphor extract
  • A kind of preparation method and application of Shishu camphor extract
  • A kind of preparation method and application of Shishu camphor extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A kind of preparation method of camphor extract, the steps are:

[0034]A. Take out the fresh Uganda ten dozen camphor bark frozen in the refrigerator at -78 or -79 or -80 or -81 or -82 ℃, and grind it to 60 or 70 or 80 or 90 or 100 mesh with a grinder.

[0035] B. Weigh the coarse powder of medicinal materials, pass through a 70 or 80 or 90 mesh sieve, add 200 mL each of methanol, n-hexane, ethyl acetate, ethanol and n-butanol at 10 times the volume (m / V), 38 or 39 or 40 Or ultrasonic treatment for 28 or 29 or 30 or 31 or 32 minutes under the condition of 41 or 42°C.

[0036] C. Centrifuge the extract at 10,000 r / min for 28 or 29 or 30 or 31 or 32 minutes to obtain a supernatant. Each solvent was repeatedly extracted 2 or 3 or 4 times respectively, and the supernatant was combined, and the organic solvent was removed by rotary evaporation at 44 or 45 or 46°C to obtain a concentrated extract.

[0037] D. The ethanol extract is freeze-dried or spray-dried to obtain an ...

Embodiment 2

[0040] A kind of preparation method of camphor extract, the steps are:

[0041] Take out the bark of fresh Uganda ten dozen camphor bark frozen in -80℃ refrigerator, and crush it with a grinder. Weigh 100.0 g of coarse medicinal powder, add 200 mL each of n-hexane, ethanol, methanol and n-butanol at 10 times the volume (m / V), and ultrasonicate for 30 min at 40 °C. The extract was centrifuged at 10000r / min for 30min to obtain the supernatant. Each solvent was extracted three times, and the supernatants were combined, and the organic solvent was removed by rotary evaporation at 45°C to obtain 9.7 g of ethanol phase extract. Take advantage of figure 2 As shown in the LC-ESI-MS detection, the main active ingredient is sesquiterpenoids.

[0042] Other steps are the same as in Example 1.

Embodiment 3

[0044] (1) Glycerin (8%, accounting for the total mass percentage of the paste, the same below), sorbitol (20%), polyethylene glycol (2%), sodium saccharin (0.3%), carboxymethyl cellulose Sodium benzoate (0.8%), sodium benzoate (0.2%), deionized water (31%) and other materials were put into an automated high-temperature (450°C) reactor, heated (75 or 80 or 86 or 90 or 95 or 100°C) and stirred to form Gel, cool (40 or 42 or 45 or 47 or 48 or 50 ℃) for use;

[0045] (2) Under the action of stirring, the prepared tens of camphor extract (3%), water and silica (10%), calcium hydrogen phosphate dihydrate (21%), tetrasodium pyrophosphate (0.2%), Sodium dihydrogen phosphate (0.1%), sodium lauryl sulfate (2.2%), natural spice mint (1.2%) and other raw materials are slowly added one by one, continue stirring to mix all kinds of materials evenly, and start cooling from 75-100 °C , slowly descend, and cool to 40 or 42 or 44 or 46 or 48 or 50°C.

[0046] (3) Cool the above materials (40...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method and application of an extract of Cinnamomum camphora. The steps are: A. Take out the bark of fresh Cinnamomum camphora from Uganda frozen in a refrigerator at -78--82°C, and crush it to 60-100 Mesh; B. Weigh the coarse powder of medicinal materials, pass through a 70-90 mesh sieve, add 200 mL each of methanol, n-hexane, ethyl acetate, ethanol and n-butanol respectively according to 10 times the volume, and ultrasonically treat at 38-42 °C for 28- 32min; C. Centrifuge the extract at 10,000r / min for 28-32min to obtain the supernatant, repeat the extraction 2-4 times for each solvent, combine the supernatant, and rotatively evaporate at 44-46°C to remove the organic solvent to obtain a concentrated extract. D. The ethanol extract is freeze-dried or spray-dried to obtain an extract of Cinnamomum camphora Uganda. The method is easy to operate and the operation is simple. Using the fresh bark of Uganda dozens of camphor trees introduced in the botanical garden as raw material, after simple crushing, ultrasonic extraction with solvent, centrifugation, impurity removal, concentration and drying, etc., the extract has strong antibacterial properties. Active ten-odd camphor extract.

Description

technical field [0001] The invention belongs to the field of ethnic medicines, and more specifically relates to a method for preparing an extract of Cinnamomum camphora, and at the same time, relates to the use of the extract of Cinnamomum in treating or preventing oral diseases. Background technique [0002] Common oral diseases such as dental caries, gingivitis, periodontitis, gingival abscess, loose teeth, etc. are closely related to oral pathogenic bacteria. Once a small wound appears in the oral cavity, the pathogenic bacteria can also reach other parts of the body along with the blood circulation, causing diseases such as arthritis and endocarditis; and because of the close relationship between the oral cavity and the maxillofacial region and the organs of the head Once the onset of the disease is often acute and severe, poor control can easily cause systemic complications. The use of chemical mouthwash is an important means to prevent and treat oral diseases. Althoug...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K8/49A61K36/185A61K31/365A61P1/02A61P31/02A61Q11/00A61K31/11A61K31/12
Inventor 郭明全王青锋朱洺志刘源振
Owner WUHAN BOTANICAL GARDEN CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com