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Wettable sulfamethoxydiazine powder and preparation method thereof

The technology of methoxine powder and trimethoprim is applied in the field of preparation of veterinary drugs, and can solve the problems of animal refueling stress, inability to achieve therapeutic effect, low drug intake and no curative effect, etc.

Active Publication Date: 2014-01-29
CHENGDU QIANKUN VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As a broad-spectrum antimicrobial drug with definite curative effect, sulfa-methoxine has been widely used in animal husbandry production in single or compound form. Currently, sulfa-methoxine tablets, compound sulfa-methoxine tablets, and compound sulfa-methoxine tablets are available. Although there are many types of dosage forms such as p-methoxine powder, compound sulfa-methoxine sodium injection, and sulfa-methoxine ditrimethoprim premix, there are still some limitations in application
For example, it is inconvenient to administer medicine when using tablets, and it is not suitable for a large number of group animals; when powders and premixes are used, they need to be administered through feed, and feed administration requires that the drug and feed be mixed evenly, but the actual operation is relatively uniform. Difficult, it is easy to cause animal poisoning due to excessive drug intake or too little drug intake without curative effect; and feed administration can easily change the flavor of the feed, causing animal refueling stress, resulting in a decrease in animal feed intake and failing to reach Therapeutic effect; the therapeutic effect of the injection formulation is good, but time-consuming and laborious, it is not suitable for large-scale farming

Method used

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  • Wettable sulfamethoxydiazine powder and preparation method thereof
  • Wettable sulfamethoxydiazine powder and preparation method thereof
  • Wettable sulfamethoxydiazine powder and preparation method thereof

Examples

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preparation example Construction

[0109] The invention also provides a preparation method of wettable sulfa-paramethoxine powder, which comprises the following steps:

[0110] a) Weigh the following raw materials:

[0111]

[0112] b) Mix the raw materials and crush them to fine powder of 625 mesh to 6250 mesh.

[0113] Preferably, the raw materials in the preparation method of wettable sulfonamide-p-methoxypyrimidine powder also include one of a flavoring agent or a carrier or a mixture of both.

[0114] In some embodiments of the present invention, the preparation method of wettable sulfa-paramethoxine powder includes the following steps:

[0115] a) Weigh the following raw materials:

[0116]

[0117]

[0118] b) Mix the raw materials and crush them to fine powder of 625 mesh to 6250 mesh.

[0119] Preferably, the raw materials in the preparation method of wettable sulfonamide-p-methoxypyrimidine powder also include one of a flavoring agent or a carrier or a mixture of both.

[0120] In other embodiments of the present ...

Embodiment 1

[0150] Example 1 Formula Screening of Wettable Sulfonamide to Methoxine Powder

[0151] The screening formula is shown in formula 1 to formula 7 in Table 1:

[0152] Table 1 Screening formula of wettable sulfonamide to methoxine powder of the present invention

[0153]

[0154]

[0155] Weigh the raw materials of each weight percentage in formula 1 to formula 7 in Table 1, mix them evenly, pulverize to 625 mesh ultra-fine powder, and package to obtain the wettable sulfapara-methyl prepared from formula 1 to formula 7 Oxypyrimidine powder.

[0156] The wettable sulfonamides prepared from formula 1 to formula 7 were evaluated for dispersion quality, sedimentation volume ratio, and palatability quality of methoxine powder.

[0157] Dispersion quality evaluation: take 1g of wettable sulfa-paramethoxine powder prepared according to formula 1 to formula 7 in Table 1, and put them into 1000mL drinking water respectively, observe or stir and observe the dispersion. The evaluation standard of d...

Embodiment 2

[0173] Example 2 Preparation of wettable sulfa-paramethoxine powder

[0174] formula:

[0175]

[0176] The above-mentioned raw materials are weighed, mixed uniformly, crushed to 625 mesh ultra-fine powder, and packaged to obtain the wettable sulfa-p-methoxypyrimidine powder of the present invention.

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Abstract

The invention relates to the technical field of veterinary medicine preparation, and particularly relates to wettable sulfamethoxydiazine powder and a preparation method thereof. The wettable sulfamethoxydiazine powder provided by the invention is added with potassium citrate, a suspending agent and a wetting agent on the basis of effective components of the original medicine; by reasonable medicine proportioning, the invention provides the wettable sulfamethoxydiazine powder which is easy to disperse evenly in water and convenient to take with water. Compared with commercially available compound sulfamethoxydiazine powder, the wettable sulfamethoxydiazine powder is good in therapeutic effect, convenient to use and small in toxic and side effects. The invention also provides the preparation method of the wettable sulfamethoxydiazine powder, and the preparation method is simple in technology, low in production cost and suitable to industrialized production.

Description

Technical field [0001] The invention relates to the field of preparation of veterinary drugs, in particular to a wettable sulfa-p-methoxypyrimidine powder and a preparation method thereof. Background technique [0002] Sulfametoxydiazine (SMD), also known as Bayrena, Durenat, Kinecid, Kirocid, Sulfameter, Sulfametin, Sulphamethoxydiazine, Sulla, long-acting sulfonamide D, methosulfonamide, anti-inflammatory sulfonamide, chemical name 2-[p-aminobenzene Sulfonamide]-5-methoxypyrimidine, the molecular formula is C 11 H 12 N 4 O 3 S, is a white or yellowish crystal or powder with odorless and slightly bitter taste. Sulfa-p-methoxypyrimidine is slightly soluble in ethanol, almost insoluble in water or ether, easily soluble in sodium hydroxide solution, slightly soluble in dilute hydrochloric acid, and has a melting point of 210°C to 214°C. [0003] Sulfa-p-methoxypyrimidine is similar in structure to p-aminobenzoic acid (PABA), and it can compete with PABA to act on the dihydrofolate s...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K9/14A61K47/38A61K47/04A61K47/10A61K33/12A61P15/02A61P29/00A61P31/04A61P33/02A61K31/505
Inventor 丁晓刚房春林李犹平徐莎
Owner CHENGDU QIANKUN VETERINARY PHARMA
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